4M38

Crystal structure of Trypanosoma brucei protein arginine methyltransferase 7 complex with AdoHcy and histone H4 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0018216	biological_process	peptidyl-arginine methylation
B	0016274	molecular_function	protein-arginine N-methyltransferase activity
B	0018216	biological_process	peptidyl-arginine methylation
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0030527	molecular_function	structural constituent of chromatin
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0030527	molecular_function	structural constituent of chromatin

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH A 401

Chain	Residue
A	HIS72
A	GLU125
A	GLY126
A	LEU130
A	MET152
A	MET153
A	SER154
A	TYR186
A	HOH505
A	MET75
A	ARG81
A	GLU101
A	GLY103
A	ALA104
A	SER106
A	LEU109
A	VAL124

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SAH B 401

Chain	Residue
B	HIS72
B	MET75
B	ARG81
B	GLU101
B	GLY103
B	ALA104
B	LEU109
B	GLU125
B	GLY126
B	LEU130
B	MET152
B	MET153
B	SER154
B	GLU172
B	TYR186
B	HOH508

---

Functional Information from PROSITE/UniProt

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
E	GLY15-HIS19

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	DNA_BIND:

Chain	Residue	Details
E	LYS17-LYS21
F	LYS17-LYS21
B	GLU172
B	GLU181

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:17967882

Chain	Residue	Details
E	SER2
F	SER2

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate => ECO:0000250|UniProtKB:P62806

Chain	Residue	Details
E	ARG4
F	ARG4

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-lactoyllysine; alternate => ECO:0000269|PubMed:31645732

Chain	Residue	Details
E	LYS6
F	LYS6

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393

Chain	Residue	Details
E	LYS9
E	LYS17
F	LYS9
F	LYS17

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
E	LYS13
F	LYS13

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:17967882, ECO:0000269|PubMed:27338793

Chain	Residue	Details
E	LYS21
F	LYS21

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447

Chain	Residue	Details
E	LYS13
F	LYS13

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
E	LYS21
F	LYS21

---