4M2L

Gamma subunit of the translation initiation factor 2 from Sulfolobus solfataricus in nucleotide-free form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0001731	biological_process	formation of translation preinitiation complex
A	0003743	molecular_function	translation initiation factor activity
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	PHE221
A	ASP222
A	LYS307
A	ALA308
A	HOH668

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 502

Chain	Residue
A	HOH855
A	LYS188
A	ARG330
A	GLU414
A	HOH665

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 503

Chain	Residue
A	LYS64
A	TYR68
A	LYS84
A	HOH667
A	HOH676

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 504

Chain	Residue
A	ASN55
A	ARG88
A	HOH646
A	HOH679
A	HOH831
A	HOH844

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 505

Chain	Residue
A	LYS234
A	SER277
A	SER278
A	HOH733
A	HOH825

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 506

Chain	Residue
A	SER161
A	ARG164
A	HOH823
A	HOH824

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 507

Chain	Residue
A	CYS62
A	LYS63
A	EDO511
A	HOH682
A	HOH740

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 508

Chain	Residue
A	TYR163
A	LYS167
A	PRO179
A	ILE180
A	HOH845

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 509

Chain	Residue
A	VAL58
A	CYS59
A	GLU60
A	SER61
A	GLU82
A	PRO83

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 510

Chain	Residue
A	GLY313
A	VAL361
A	SER364
A	VAL386
A	ALA387
A	TRP389
A	HOH758
A	HOH760

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 511

Chain	Residue
A	SER61
A	CYS77
A	GLY78
A	PO4507

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 512

Chain	Residue
A	THR173
A	TRP174

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 513

Chain	Residue
A	ASN11
A	ASP112
A	ARG207
A	ILE242
A	ILE243
A	GLY292

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 514

Chain	Residue
A	ARG394
A	HOH798

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 515

Chain	Residue
A	LYS212
A	GLN244
A	TRP389

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 516

Chain	Residue
A	ARG130
A	ARG338

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 517

Chain	Residue
A	SER73
A	LYS75
A	SER76
A	EDO518
A	HOH686

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 518

Chain	Residue
A	SER73
A	LYS75
A	EDO517
A	HOH702

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 519

Chain	Residue
A	GLU355
A	THR356
A	HOH652
A	HOH826

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 520

Chain	Residue
A	THR46
A	ARG280
A	GLY282
A	ALA296

---

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 521

Chain	Residue
A	PRO182
A	ASN190
A	THR371
A	HOH614
A	HOH839

---

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 522

Chain	Residue
A	GLN251
A	GLU252
A	HOH687

---

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 523

Chain	Residue
A	LEU259
A	ARG260
A	ASN310
A	ARG384
A	GLY258

---

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 524

Chain	Residue
A	SER61
A	LYS84
A	HOH739

---

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 525

Chain	Residue
A	ASN391

---

site_id	CC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 526

Chain	Residue
A	LEU105
A	SER360
A	VAL361
A	GLY362
A	VAL396
A	EDO533
A	HOH655

---

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 527

Chain	Residue
A	CYS62
A	LYS64
A	HOH796
A	HOH841

---

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 528

Chain	Residue
A	SER363
A	SER364
A	THR365

---

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 529

Chain	Residue
A	ILE32
A	ALA52
A	GLU53
A	GLY282
A	HOH806

---

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 530

Chain	Residue
A	HIS17
A	ASP19
A	VAL118
A	ALA119
A	GLU122

---

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 531

Chain	Residue
A	LYS212
A	ALA321
A	GLU322

---

site_id	DC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 532

Chain	Residue
A	ASN190
A	ILE191
A	ASP192
A	SER372
A	LYS374
A	GLU379
A	HOH617

---

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 533

Chain	Residue
A	ALA108
A	MET111
A	ILE139
A	EDO526
A	HOH790

---

site_id	DC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 534

Chain	Residue
A	HIS20
A	ASN149
A	LYS150
A	SER184
A	ALA185
A	LEU186
A	HOH662

---

site_id	DC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 535

Chain	Residue
A	GLN400
A	ALA402

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Region: {"description":"G1","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Region: {"description":"G4","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Region: {"description":"G5","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RD1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RD1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16407071","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8U082","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---