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4LYJ

Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C, alternative space group

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007165biological_processsignal transduction
A0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 201
ChainResidue
ASER17
ATYR32
AGDP203
AHOH312
AHOH360

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 21F A 202
ChainResidue
AGLU62
AGLU63
AARG68
ATYR71
AMET72
ATYR96
AGLN99
AHOH362
AVAL9
AGLY10
ACYS12
ATHR58

site_idAC3
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GDP A 203
ChainResidue
AALA11
AGLY13
AVAL14
AGLY15
ALYS16
ASER17
AALA18
APHE28
AVAL29
AASP30
ATYR32
AASN116
ALYS117
AASP119
ALEU120
ASER145
AALA146
ALYS147
AMG201
AHOH307
AHOH322
AHOH330
AHOH335
AHOH350
AHOH374

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140
ChainResidueDetails
AGLY10
AVAL29
AALA59
AASN116

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17
ChainResidueDetails
AMET1

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17
ChainResidueDetails
ATHR2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838
ChainResidueDetails
ALYS104

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486
ChainResidueDetails
ATHR35

221716

PDB entries from 2024-06-26

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