4LX9

Archaeal amino-terminal acetyltransferase (NAT) bound to acetyl coenzyme A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006474	biological_process	N-terminal protein amino acid acetylation
A	0008080	molecular_function	N-acetyltransferase activity
A	0008999	molecular_function	protein-N-terminal-alanine acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0031415	cellular_component	NatA complex
A	0046872	molecular_function	metal ion binding
A	0120518	molecular_function	protein N-terminal-methionine acetyltransferase activity
A	1990189	molecular_function	protein N-terminal-serine acetyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	BINDING SITE FOR RESIDUE ACO A 301

Chain	Residue
A	THR81
A	LYS150
A	GLY151
A	ILE152
A	ALA153
A	THR154
A	GLU176
A	ASN181
A	TYR182
A	PRO183
A	LEU187
A	LEU82
A	TYR188
A	LYS190
A	ARG214
A	HOH410
A	HOH411
A	HOH415
A	HOH427
A	HOH461
A	HOH475
A	HOH496
A	VAL138
A	HOH515
A	HOH528
A	HOH536
A	HOH538
A	SER140
A	ILE141
A	ALA142
A	VAL143
A	ARG148
A	ARG149

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	HIS137
A	GLU176
A	HOH405
A	HOH412
A	HOH520

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 303

Chain	Residue
A	GLU145
A	ASP167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	155
Details	Domain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25728374","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R3L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23959863","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LX9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20419351","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23959863","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25728374","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26593285","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X7B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R3K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R3L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5C88","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20419351","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23959863","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25728374","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X7B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R3K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R3L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Plays an important role in substrate specificity","evidences":[{"source":"PubMed","id":"25728374","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Site: {"description":"Plays an important role in modulating multiple conformations of loop regions and contributes to protein thermostability","evidences":[{"source":"PubMed","id":"26593285","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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