4LVG
Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006741 | biological_process | NADP+ biosynthetic process |
| A | 0006954 | biological_process | inflammatory response |
| A | 0007165 | biological_process | signal transduction |
| A | 0007267 | biological_process | cell-cell signaling |
| A | 0007623 | biological_process | circadian rhythm |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0008286 | biological_process | insulin receptor signaling pathway |
| A | 0009435 | biological_process | NAD+ biosynthetic process |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| A | 0032922 | biological_process | circadian regulation of gene expression |
| A | 0034355 | biological_process | NAD+ biosynthetic process via the salvage pathway |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0047280 | molecular_function | nicotinamide phosphoribosyltransferase activity |
| A | 0048511 | biological_process | rhythmic process |
| A | 0060612 | biological_process | adipose tissue development |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| A | 1901847 | biological_process | nicotinate metabolic process |
| B | 0005125 | molecular_function | cytokine activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005829 | cellular_component | cytosol |
| B | 0006741 | biological_process | NADP+ biosynthetic process |
| B | 0006954 | biological_process | inflammatory response |
| B | 0007165 | biological_process | signal transduction |
| B | 0007267 | biological_process | cell-cell signaling |
| B | 0007623 | biological_process | circadian rhythm |
| B | 0008284 | biological_process | positive regulation of cell population proliferation |
| B | 0008286 | biological_process | insulin receptor signaling pathway |
| B | 0009435 | biological_process | NAD+ biosynthetic process |
| B | 0010628 | biological_process | positive regulation of gene expression |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| B | 0032922 | biological_process | circadian regulation of gene expression |
| B | 0034355 | biological_process | NAD+ biosynthetic process via the salvage pathway |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 0047280 | molecular_function | nicotinamide phosphoribosyltransferase activity |
| B | 0048511 | biological_process | rhythmic process |
| B | 0060612 | biological_process | adipose tissue development |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| B | 1901847 | biological_process | nicotinate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 20O A 601 |
| Chain | Residue |
| A | TYR188 |
| A | ARG311 |
| A | ILE351 |
| A | ALA379 |
| A | HOH733 |
| A | HOH770 |
| A | HOH835 |
| B | TYR18 |
| B | EDO607 |
| A | HIS191 |
| A | PHE193 |
| A | ARG196 |
| A | ASP219 |
| A | VAL242 |
| A | ALA244 |
| A | ALA245 |
| A | SER275 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 602 |
| Chain | Residue |
| A | ARG392 |
| A | SER398 |
| A | LYS400 |
| A | EDO605 |
| A | HOH741 |
| A | HOH749 |
| A | HOH780 |
| A | HOH795 |
| A | HOH932 |
| B | ARG196 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 603 |
| Chain | Residue |
| A | ARG196 |
| A | GLU246 |
| A | HIS247 |
| A | ARG311 |
| A | HOH736 |
| A | HOH816 |
| B | TYR18 |
| B | HOH757 |
| B | HOH821 |
| B | HOH909 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 604 |
| Chain | Residue |
| A | GLY353 |
| A | GLY355 |
| A | GLY383 |
| A | GLY384 |
| A | HOH723 |
| A | HOH930 |
| A | HOH941 |
| A | HOH1066 |
| A | HOH1165 |
| B | EDO607 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 605 |
| Chain | Residue |
| A | ARG40 |
| A | ARG392 |
| A | ASP393 |
| A | ASN396 |
| A | CYS397 |
| A | PO4602 |
| A | HOH1011 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 606 |
| Chain | Residue |
| A | LYS400 |
| A | CYS401 |
| A | PHE414 |
| A | HOH781 |
| B | HIS247 |
| B | SER248 |
| B | THR251 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 607 |
| Chain | Residue |
| A | HIS247 |
| A | SER248 |
| A | THR251 |
| A | HOH736 |
| B | LYS400 |
| B | CYS401 |
| B | PHE414 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 608 |
| Chain | Residue |
| A | PHE9 |
| A | ASN10 |
| A | LEU13 |
| A | HOH908 |
| A | HOH1093 |
| B | TYR195 |
| B | ALA222 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 609 |
| Chain | Residue |
| A | GLY315 |
| A | ASP354 |
| A | GLY355 |
| A | HOH1055 |
| A | HOH1060 |
| B | HOH819 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 610 |
| Chain | Residue |
| A | GLU187 |
| A | VAL213 |
| A | ASN214 |
| A | LYS216 |
| A | ARG477 |
| A | HOH818 |
| A | HOH1124 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 611 |
| Chain | Residue |
| A | ARG392 |
| A | HOH780 |
| A | HOH880 |
| A | HOH907 |
| B | PHE193 |
| B | 20O601 |
| B | PO4604 |
| site_id | BC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 20O B 601 |
| Chain | Residue |
| B | PHE193 |
| B | ARG196 |
| B | ASP219 |
| B | ALA244 |
| B | SER275 |
| B | ARG311 |
| B | ILE351 |
| B | ALA379 |
| B | HOH714 |
| B | HOH716 |
| B | HOH828 |
| B | HOH830 |
| A | TYR18 |
| A | EDO611 |
| B | TYR188 |
| B | HIS191 |
| site_id | BC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 B 602 |
| Chain | Residue |
| A | TYR18 |
| A | HOH776 |
| A | HOH780 |
| A | HOH781 |
| A | HOH795 |
| B | ARG196 |
| B | GLU246 |
| B | HIS247 |
| B | ARG311 |
| B | HOH804 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 B 603 |
| Chain | Residue |
| A | ARG196 |
| B | ARG392 |
| B | SER398 |
| B | LYS400 |
| B | EDO605 |
| B | HOH727 |
| B | HOH743 |
| B | HOH821 |
| B | HOH909 |
| B | HOH1002 |
| site_id | BC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PO4 B 604 |
| Chain | Residue |
| A | EDO611 |
| B | GLY353 |
| B | GLY355 |
| B | SER382 |
| B | GLY383 |
| B | GLY384 |
| B | HOH844 |
| B | HOH865 |
| B | HOH914 |
| B | HOH919 |
| B | HOH1016 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 605 |
| Chain | Residue |
| B | ARG40 |
| B | ARG392 |
| B | ASP393 |
| B | ASN396 |
| B | CYS397 |
| B | SER398 |
| B | PO4603 |
| B | HOH993 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 606 |
| Chain | Residue |
| A | HOH847 |
| B | GLY315 |
| B | ASP354 |
| B | GLY355 |
| B | HOH867 |
| B | HOH1041 |
| B | HOH1129 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 607 |
| Chain | Residue |
| A | PHE193 |
| A | 20O601 |
| A | PO4604 |
| B | ARG392 |
| B | HOH842 |
| B | HOH898 |
| B | HOH909 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
