4LV5
Murine IRGa6 bound to Toxoplasma ROP5B, a pseudokinase GDI
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0000045 | biological_process | autophagosome assembly |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0002376 | biological_process | immune system process |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0009617 | biological_process | response to bacterium |
| B | 0010506 | biological_process | regulation of autophagy |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019003 | molecular_function | GDP binding |
| B | 0019221 | biological_process | cytokine-mediated signaling pathway |
| B | 0020005 | cellular_component | symbiont-containing vacuole membrane |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0032580 | cellular_component | Golgi cisterna membrane |
| B | 0035458 | biological_process | cellular response to interferon-beta |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042832 | biological_process | defense response to protozoan |
| B | 0045087 | biological_process | innate immune response |
| B | 0050829 | biological_process | defense response to Gram-negative bacterium |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP A 601 |
| Chain | Residue |
| A | ARG241 |
| A | PRO338 |
| A | ALA340 |
| A | ASP343 |
| A | ASP393 |
| A | PHE396 |
| A | HOH714 |
| A | HOH732 |
| A | HOH773 |
| A | HOH837 |
| A | HOH854 |
| A | GLY243 |
| A | HOH868 |
| A | HOH895 |
| A | ASP244 |
| A | SER246 |
| A | VAL248 |
| A | ALA261 |
| A | LYS263 |
| A | LEU304 |
| A | MET337 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME A 602 |
| Chain | Residue |
| A | CYS195 |
| A | ALA199 |
| A | SER349 |
| A | HOH887 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 603 |
| Chain | Residue |
| A | LEU304 |
| A | PRO306 |
| A | ASP407 |
| A | VAL408 |
| A | HOH714 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 604 |
| Chain | Residue |
| A | ASN218 |
| A | ALA219 |
| A | ALA443 |
| A | ARG511 |
| A | ARG512 |
| A | ARG513 |
| A | ARG514 |
| A | HOH850 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 605 |
| Chain | Residue |
| A | TYR454 |
| A | PHE460 |
| A | LEU461 |
| A | PRO462 |
| A | PHE463 |
| A | GLY464 |
| A | HOH704 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 606 |
| Chain | Residue |
| A | LYS263 |
| A | LEU279 |
| A | LEU335 |
| A | HOH854 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GDP B 501 |
| Chain | Residue |
| B | GLY79 |
| B | SER80 |
| B | GLY81 |
| B | LYS82 |
| B | SER83 |
| B | SER84 |
| B | THR102 |
| B | LYS184 |
| B | ASP186 |
| B | SER187 |
| B | SER231 |
| B | ASN232 |
| B | LYS233 |
| B | HOH700 |
| B | HOH709 |
| B | HOH822 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 502 |
| Chain | Residue |
| B | TYR23 |
| B | LYS279 |
| B | HOH833 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 503 |
| Chain | Residue |
| A | GLU277 |
| A | PHE318 |
| B | ILE294 |
| B | HOH796 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21708941","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3Q60","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 182 |
| Details | Domain: {"description":"IRG-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01053","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12732635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25118287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25118287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12732635","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25118287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LV5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"(Microbial infection) Phosphothreonine; by ROP18","evidences":[{"source":"PubMed","id":"21203588","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
