4LSM
Crystal structure of a glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD A 401 |
| Chain | Residue |
| A | GLY15 |
| A | THR103 |
| A | GLY104 |
| A | LEU105 |
| A | THR126 |
| A | CYS156 |
| A | ALA187 |
| A | ASN320 |
| A | TYR324 |
| A | HOH509 |
| A | HOH524 |
| A | PHE16 |
| A | HOH540 |
| A | HOH560 |
| A | HOH623 |
| A | HOH682 |
| A | HOH684 |
| A | HOH685 |
| A | HOH687 |
| A | HOH688 |
| A | HOH702 |
| A | HOH770 |
| A | GLY17 |
| B | PRO195 |
| A | ARG18 |
| A | ILE19 |
| A | ASN39 |
| A | ASP40 |
| A | ARG84 |
| A | SER102 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 402 |
| Chain | Residue |
| A | PRO134 |
| A | MET135 |
| A | ASN141 |
| A | HOH506 |
| A | HOH663 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 403 |
| Chain | Residue |
| A | ARG201 |
| A | PRO212 |
| A | SER213 |
| A | HOH558 |
| B | GLU284 |
| B | LYS302 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 404 |
| Chain | Residue |
| A | GLU284 |
| A | LYS302 |
| A | HOH581 |
| B | ARG201 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 405 |
| Chain | Residue |
| A | ARG59 |
| A | MET290 |
| A | HOH523 |
| A | HOH838 |
| site_id | AC6 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD B 401 |
| Chain | Residue |
| A | PRO195 |
| B | ASN14 |
| B | GLY15 |
| B | PHE16 |
| B | GLY17 |
| B | ARG18 |
| B | ILE19 |
| B | ASN39 |
| B | ASP40 |
| B | ARG84 |
| B | SER102 |
| B | THR103 |
| B | GLY104 |
| B | LEU105 |
| B | THR126 |
| B | ALA187 |
| B | ASN320 |
| B | TYR324 |
| B | HOH517 |
| B | HOH528 |
| B | HOH539 |
| B | HOH652 |
| B | HOH654 |
| B | HOH660 |
| B | HOH663 |
| B | HOH664 |
| B | HOH665 |
| B | HOH676 |
| B | HOH677 |
| B | HOH757 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 402 |
| Chain | Residue |
| B | PRO134 |
| B | MET135 |
| B | LYS223 |
| B | HOH583 |
| B | HOH623 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 403 |
| Chain | Residue |
| B | ARG59 |
| B | HOH614 |
Functional Information from PROSITE/UniProt
| site_id | PS00071 |
| Number of Residues | 8 |
| Details | GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL |
| Chain | Residue | Details |
| A | ALA154-LEU161 |
