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4LOM

Crystal Structure of Mycobacterium tuberculosis HisB in complex with its substrate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000105biological_processL-histidine biosynthetic process
A0004424molecular_functionimidazoleglycerol-phosphate dehydratase activity
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE IYP A 301
ChainResidue
AGLU21
AHIS177
AGLU180
ALYS184
AMN302
AMN303
AHOH460
AHIS47
AHIS73
AHIS74
AGLU77
AARG99
AMET107
AARG121
AHIS176

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN A 302
ChainResidue
AHIS73
AGLU77
AHIS152
AHIS177
AIYP301
AHOH460

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN A 303
ChainResidue
AHIS47
AHIS74
AHIS176
AGLU180
AIYP301

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MN A 304
ChainResidue
AARG168
AARG168
AARG168

Functional Information from PROSITE/UniProt
site_idPS00954
Number of Residues14
DetailsIGP_DEHYDRATASE_1 Imidazoleglycerol-phosphate dehydratase signature 1. IEaHHtiEdtAIAL
ChainResidueDetails
AILE70-LEU83

site_idPS00955
Number of Residues13
DetailsIGP_DEHYDRATASE_2 Imidazoleglycerol-phosphate dehydratase signature 2. GrDpHHitEAqYK
ChainResidueDetails
AGLY172-LYS184

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PDB entries from 2024-10-30

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