4LNI
B. subtilis glutamine synthetase structures reveal large active site conformational changes and basis for isoenzyme specific regulation: structure of the transition state complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004356 | molecular_function | glutamine synthetase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006542 | biological_process | glutamine biosynthetic process |
| A | 0016595 | molecular_function | glutamate binding |
| A | 0016874 | molecular_function | ligase activity |
| A | 0043562 | biological_process | cellular response to nitrogen levels |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070406 | molecular_function | glutamine binding |
| A | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| A | 0140297 | molecular_function | DNA-binding transcription factor binding |
| A | 0140416 | molecular_function | transcription regulator inhibitor activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004356 | molecular_function | glutamine synthetase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006542 | biological_process | glutamine biosynthetic process |
| B | 0016595 | molecular_function | glutamate binding |
| B | 0016874 | molecular_function | ligase activity |
| B | 0043562 | biological_process | cellular response to nitrogen levels |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070406 | molecular_function | glutamine binding |
| B | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| B | 0140297 | molecular_function | DNA-binding transcription factor binding |
| B | 0140416 | molecular_function | transcription regulator inhibitor activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004356 | molecular_function | glutamine synthetase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006542 | biological_process | glutamine biosynthetic process |
| C | 0016595 | molecular_function | glutamate binding |
| C | 0016874 | molecular_function | ligase activity |
| C | 0043562 | biological_process | cellular response to nitrogen levels |
| C | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070406 | molecular_function | glutamine binding |
| C | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| C | 0140297 | molecular_function | DNA-binding transcription factor binding |
| C | 0140416 | molecular_function | transcription regulator inhibitor activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004356 | molecular_function | glutamine synthetase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006542 | biological_process | glutamine biosynthetic process |
| D | 0016595 | molecular_function | glutamate binding |
| D | 0016874 | molecular_function | ligase activity |
| D | 0043562 | biological_process | cellular response to nitrogen levels |
| D | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070406 | molecular_function | glutamine binding |
| D | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| D | 0140297 | molecular_function | DNA-binding transcription factor binding |
| D | 0140416 | molecular_function | transcription regulator inhibitor activity |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004356 | molecular_function | glutamine synthetase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006542 | biological_process | glutamine biosynthetic process |
| E | 0016595 | molecular_function | glutamate binding |
| E | 0016874 | molecular_function | ligase activity |
| E | 0043562 | biological_process | cellular response to nitrogen levels |
| E | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070406 | molecular_function | glutamine binding |
| E | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| E | 0140297 | molecular_function | DNA-binding transcription factor binding |
| E | 0140416 | molecular_function | transcription regulator inhibitor activity |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004356 | molecular_function | glutamine synthetase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006542 | biological_process | glutamine biosynthetic process |
| F | 0016595 | molecular_function | glutamate binding |
| F | 0016874 | molecular_function | ligase activity |
| F | 0043562 | biological_process | cellular response to nitrogen levels |
| F | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070406 | molecular_function | glutamine binding |
| F | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| F | 0140297 | molecular_function | DNA-binding transcription factor binding |
| F | 0140416 | molecular_function | transcription regulator inhibitor activity |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0000287 | molecular_function | magnesium ion binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004356 | molecular_function | glutamine synthetase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006542 | biological_process | glutamine biosynthetic process |
| G | 0016595 | molecular_function | glutamate binding |
| G | 0016874 | molecular_function | ligase activity |
| G | 0043562 | biological_process | cellular response to nitrogen levels |
| G | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0070406 | molecular_function | glutamine binding |
| G | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| G | 0140297 | molecular_function | DNA-binding transcription factor binding |
| G | 0140416 | molecular_function | transcription regulator inhibitor activity |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0000287 | molecular_function | magnesium ion binding |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004356 | molecular_function | glutamine synthetase activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006542 | biological_process | glutamine biosynthetic process |
| H | 0016595 | molecular_function | glutamate binding |
| H | 0016874 | molecular_function | ligase activity |
| H | 0043562 | biological_process | cellular response to nitrogen levels |
| H | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0070406 | molecular_function | glutamine binding |
| H | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| H | 0140297 | molecular_function | DNA-binding transcription factor binding |
| H | 0140416 | molecular_function | transcription regulator inhibitor activity |
| I | 0000166 | molecular_function | nucleotide binding |
| I | 0000287 | molecular_function | magnesium ion binding |
| I | 0003824 | molecular_function | catalytic activity |
| I | 0004356 | molecular_function | glutamine synthetase activity |
| I | 0005515 | molecular_function | protein binding |
| I | 0005524 | molecular_function | ATP binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0006542 | biological_process | glutamine biosynthetic process |
| I | 0016595 | molecular_function | glutamate binding |
| I | 0016874 | molecular_function | ligase activity |
| I | 0043562 | biological_process | cellular response to nitrogen levels |
| I | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| I | 0046872 | molecular_function | metal ion binding |
| I | 0070406 | molecular_function | glutamine binding |
| I | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| I | 0140297 | molecular_function | DNA-binding transcription factor binding |
| I | 0140416 | molecular_function | transcription regulator inhibitor activity |
| J | 0000166 | molecular_function | nucleotide binding |
| J | 0000287 | molecular_function | magnesium ion binding |
| J | 0003824 | molecular_function | catalytic activity |
| J | 0004356 | molecular_function | glutamine synthetase activity |
| J | 0005515 | molecular_function | protein binding |
| J | 0005524 | molecular_function | ATP binding |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0006542 | biological_process | glutamine biosynthetic process |
| J | 0016595 | molecular_function | glutamate binding |
| J | 0016874 | molecular_function | ligase activity |
| J | 0043562 | biological_process | cellular response to nitrogen levels |
| J | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0070406 | molecular_function | glutamine binding |
| J | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| J | 0140297 | molecular_function | DNA-binding transcription factor binding |
| J | 0140416 | molecular_function | transcription regulator inhibitor activity |
| K | 0000166 | molecular_function | nucleotide binding |
| K | 0000287 | molecular_function | magnesium ion binding |
| K | 0003824 | molecular_function | catalytic activity |
| K | 0004356 | molecular_function | glutamine synthetase activity |
| K | 0005515 | molecular_function | protein binding |
| K | 0005524 | molecular_function | ATP binding |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0006542 | biological_process | glutamine biosynthetic process |
| K | 0016595 | molecular_function | glutamate binding |
| K | 0016874 | molecular_function | ligase activity |
| K | 0043562 | biological_process | cellular response to nitrogen levels |
| K | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| K | 0046872 | molecular_function | metal ion binding |
| K | 0070406 | molecular_function | glutamine binding |
| K | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| K | 0140297 | molecular_function | DNA-binding transcription factor binding |
| K | 0140416 | molecular_function | transcription regulator inhibitor activity |
| L | 0000166 | molecular_function | nucleotide binding |
| L | 0000287 | molecular_function | magnesium ion binding |
| L | 0003824 | molecular_function | catalytic activity |
| L | 0004356 | molecular_function | glutamine synthetase activity |
| L | 0005515 | molecular_function | protein binding |
| L | 0005524 | molecular_function | ATP binding |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0006542 | biological_process | glutamine biosynthetic process |
| L | 0016595 | molecular_function | glutamate binding |
| L | 0016874 | molecular_function | ligase activity |
| L | 0043562 | biological_process | cellular response to nitrogen levels |
| L | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0070406 | molecular_function | glutamine binding |
| L | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| L | 0140297 | molecular_function | DNA-binding transcription factor binding |
| L | 0140416 | molecular_function | transcription regulator inhibitor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE P3S A 501 |
| Chain | Residue |
| A | GLU132 |
| A | ARG335 |
| A | ADP502 |
| A | MG503 |
| A | MG504 |
| A | MG505 |
| A | HOH616 |
| A | HOH623 |
| A | HOH658 |
| A | HOH684 |
| A | GLU134 |
| A | GLU189 |
| A | GLY241 |
| A | HIS245 |
| A | ARG298 |
| A | GLU304 |
| A | ALA305 |
| A | ARG316 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ADP A 502 |
| Chain | Residue |
| A | GLY130 |
| A | GLU132 |
| A | GLU184 |
| A | GLU196 |
| A | ASP198 |
| A | PHE199 |
| A | LYS200 |
| A | TYR201 |
| A | ASN247 |
| A | SER249 |
| A | ARG321 |
| A | ILE328 |
| A | SER329 |
| A | ARG331 |
| A | GLU333 |
| A | P3S501 |
| A | MG504 |
| A | MG505 |
| A | HOH626 |
| A | HOH676 |
| A | HOH723 |
| B | MET51 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 503 |
| Chain | Residue |
| A | GLU134 |
| A | GLU189 |
| A | GLU196 |
| A | P3S501 |
| A | MG505 |
| A | HOH684 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 504 |
| Chain | Residue |
| A | GLU132 |
| A | HIS245 |
| A | GLU333 |
| A | P3S501 |
| A | ADP502 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 505 |
| Chain | Residue |
| A | GLU132 |
| A | GLU196 |
| A | ASP198 |
| A | P3S501 |
| A | ADP502 |
| A | MG503 |
| A | HOH626 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE P3S B 501 |
| Chain | Residue |
| B | GLU132 |
| B | GLU134 |
| B | GLU189 |
| B | GLY241 |
| B | HIS245 |
| B | ARG298 |
| B | GLU304 |
| B | ARG316 |
| B | ARG335 |
| B | ADP502 |
| B | MG503 |
| B | MG504 |
| B | MG505 |
| B | HOH614 |
| B | HOH706 |
| C | ASP53 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ADP B 502 |
| Chain | Residue |
| B | GLY130 |
| B | GLU132 |
| B | GLU184 |
| B | GLU196 |
| B | ASP198 |
| B | PHE199 |
| B | LYS200 |
| B | TYR201 |
| B | ASN247 |
| B | SER249 |
| B | ASN256 |
| B | ARG316 |
| B | ARG321 |
| B | ILE328 |
| B | ARG331 |
| B | GLU333 |
| B | P3S501 |
| B | MG504 |
| B | MG505 |
| B | HOH658 |
| B | HOH706 |
| B | HOH716 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 503 |
| Chain | Residue |
| B | GLU196 |
| B | P3S501 |
| B | MG505 |
| B | HOH653 |
| B | GLU132 |
| B | GLU134 |
| B | GLU189 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 504 |
| Chain | Residue |
| B | GLU132 |
| B | HIS245 |
| B | GLU333 |
| B | P3S501 |
| B | ADP502 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG B 505 |
| Chain | Residue |
| B | GLU132 |
| B | GLU196 |
| B | ASP198 |
| B | P3S501 |
| B | ADP502 |
| B | MG503 |
| B | HOH658 |
| B | HOH706 |
| site_id | BC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE P3S C 501 |
| Chain | Residue |
| C | GLU132 |
| C | GLU134 |
| C | GLU189 |
| C | VAL190 |
| C | GLU196 |
| C | GLY241 |
| C | HIS245 |
| C | ARG298 |
| C | GLU304 |
| C | ARG316 |
| C | ARG335 |
| C | ADP502 |
| C | MG503 |
| C | MG504 |
| C | MG505 |
| C | HOH647 |
| C | HOH681 |
| C | HOH689 |
| C | HOH708 |
| C | HOH718 |
| D | ASP53 |
| site_id | BC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE ADP C 502 |
| Chain | Residue |
| C | ASN128 |
| C | GLY130 |
| C | GLU132 |
| C | GLU184 |
| C | GLU196 |
| C | ASP198 |
| C | PHE199 |
| C | LYS200 |
| C | TYR201 |
| C | ASN247 |
| C | SER249 |
| C | ASN256 |
| C | ARG321 |
| C | ILE328 |
| C | ARG331 |
| C | GLU333 |
| C | P3S501 |
| C | MG504 |
| C | MG505 |
| C | HOH609 |
| C | HOH656 |
| C | HOH657 |
| C | HOH699 |
| C | HOH740 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 503 |
| Chain | Residue |
| C | GLU134 |
| C | GLU189 |
| C | GLU196 |
| C | P3S501 |
| C | HOH681 |
| C | HOH689 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 504 |
| Chain | Residue |
| C | GLU132 |
| C | HIS245 |
| C | GLU333 |
| C | P3S501 |
| C | ADP502 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 505 |
| Chain | Residue |
| C | GLU132 |
| C | GLU196 |
| C | P3S501 |
| C | ADP502 |
| C | HOH656 |
| C | HOH681 |
| site_id | BC7 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE P3S D 501 |
| Chain | Residue |
| D | GLU132 |
| D | GLU134 |
| D | GLU189 |
| D | VAL190 |
| D | GLU196 |
| D | GLY241 |
| D | HIS245 |
| D | ARG298 |
| D | GLU304 |
| D | ALA305 |
| D | ARG316 |
| D | ARG335 |
| D | ADP502 |
| D | MG503 |
| D | MG504 |
| D | MG505 |
| D | HOH614 |
| D | HOH657 |
| D | HOH735 |
| E | ASP53 |
| site_id | BC8 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP D 502 |
| Chain | Residue |
| D | GLY130 |
| D | GLU132 |
| D | GLU184 |
| D | GLU196 |
| D | ASP198 |
| D | PHE199 |
| D | LYS200 |
| D | TYR201 |
| D | ASN247 |
| D | SER249 |
| D | ASN256 |
| D | ARG321 |
| D | ILE328 |
| D | SER329 |
| D | ARG331 |
| D | GLU333 |
| D | P3S501 |
| D | MG504 |
| D | MG505 |
| D | HOH620 |
| D | HOH787 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 503 |
| Chain | Residue |
| D | GLU134 |
| D | GLU189 |
| D | GLU196 |
| D | P3S501 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 504 |
| Chain | Residue |
| D | GLU132 |
| D | HIS245 |
| D | GLU333 |
| D | P3S501 |
| D | ADP502 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 505 |
| Chain | Residue |
| D | GLU132 |
| D | GLU196 |
| D | P3S501 |
| D | ADP502 |
| D | HOH670 |
| site_id | CC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE P3S E 501 |
| Chain | Residue |
| E | GLU132 |
| E | GLU134 |
| E | GLU189 |
| E | VAL190 |
| E | GLU196 |
| E | GLY241 |
| E | HIS245 |
| E | ARG298 |
| E | GLU304 |
| E | ARG316 |
| E | ARG335 |
| E | ADP502 |
| E | MG503 |
| E | MG504 |
| E | MG505 |
| E | HOH613 |
| E | HOH615 |
| F | ASP53 |
| site_id | CC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP E 502 |
| Chain | Residue |
| E | GLY130 |
| E | GLU132 |
| E | GLU184 |
| E | GLU196 |
| E | ASP198 |
| E | PHE199 |
| E | LYS200 |
| E | TYR201 |
| E | ASN247 |
| E | SER249 |
| E | ASN256 |
| E | ARG321 |
| E | ILE328 |
| E | ARG331 |
| E | GLU333 |
| E | P3S501 |
| E | MG504 |
| E | MG505 |
| E | HOH602 |
| E | HOH655 |
| F | MET51 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG E 503 |
| Chain | Residue |
| E | GLU134 |
| E | GLU189 |
| E | GLU196 |
| E | P3S501 |
| E | MG505 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG E 504 |
| Chain | Residue |
| E | GLU132 |
| E | HIS245 |
| E | GLU333 |
| E | P3S501 |
| E | ADP502 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG E 505 |
| Chain | Residue |
| E | GLU132 |
| E | GLU196 |
| E | P3S501 |
| E | ADP502 |
| E | MG503 |
| E | HOH655 |
| site_id | CC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE P3S F 601 |
| Chain | Residue |
| A | ASP53 |
| F | GLU132 |
| F | GLU134 |
| F | GLU189 |
| F | VAL190 |
| F | GLY241 |
| F | GLY243 |
| F | HIS245 |
| F | ARG298 |
| F | GLU304 |
| F | ARG316 |
| F | ARG335 |
| F | ADP602 |
| F | MG603 |
| F | MG604 |
| F | MG605 |
| F | HOH703 |
| F | HOH789 |
| site_id | CC9 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE ADP F 602 |
| Chain | Residue |
| F | GLY130 |
| F | GLU132 |
| F | GLU184 |
| F | GLU196 |
| F | ASP198 |
| F | PHE199 |
| F | LYS200 |
| F | TYR201 |
| F | ASN247 |
| F | SER249 |
| F | ASN256 |
| F | ARG316 |
| F | ARG321 |
| F | ILE328 |
| F | SER329 |
| F | THR330 |
| F | ARG331 |
| F | GLU333 |
| F | P3S601 |
| F | MG604 |
| F | MG605 |
| F | HOH731 |
| F | HOH785 |
| F | HOH817 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG F 603 |
| Chain | Residue |
| F | GLU134 |
| F | GLU189 |
| F | GLU196 |
| F | P3S601 |
| F | HOH840 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG F 604 |
| Chain | Residue |
| F | GLU132 |
| F | HIS245 |
| F | GLU333 |
| F | P3S601 |
| F | ADP602 |
| site_id | DC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG F 605 |
| Chain | Residue |
| F | GLU132 |
| F | GLU196 |
| F | ASP198 |
| F | P3S601 |
| F | ADP602 |
| F | HOH785 |
| site_id | DC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE P3S G 601 |
| Chain | Residue |
| G | GLU132 |
| G | GLU134 |
| G | GLU189 |
| G | VAL190 |
| G | GLU196 |
| G | GLY241 |
| G | HIS245 |
| G | ARG298 |
| G | GLU304 |
| G | ARG316 |
| G | ARG335 |
| G | ADP602 |
| G | MG603 |
| G | MG604 |
| G | MG605 |
| G | HOH716 |
| G | HOH751 |
| G | HOH780 |
| G | HOH781 |
| site_id | DC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ADP G 602 |
| Chain | Residue |
| G | GLY130 |
| G | GLU132 |
| G | GLU184 |
| G | GLU196 |
| G | ASP198 |
| G | PHE199 |
| G | TYR201 |
| G | ASN247 |
| G | SER249 |
| G | ARG321 |
| G | ILE328 |
| G | ARG331 |
| G | GLU333 |
| G | P3S601 |
| G | MG604 |
| G | MG605 |
| G | HOH754 |
| G | HOH794 |
| G | HOH853 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG G 603 |
| Chain | Residue |
| G | GLU134 |
| G | GLU189 |
| G | GLU196 |
| G | P3S601 |
| G | MG605 |
| G | HOH751 |
| site_id | DC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG G 604 |
| Chain | Residue |
| G | GLU132 |
| G | HIS245 |
| G | GLU333 |
| G | P3S601 |
| G | ADP602 |
| G | MG605 |
| site_id | DC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG G 605 |
| Chain | Residue |
| G | GLU132 |
| G | GLU196 |
| G | P3S601 |
| G | ADP602 |
| G | MG603 |
| G | MG604 |
| G | HOH754 |
| site_id | DC9 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE P3S H 601 |
| Chain | Residue |
| G | ASP53 |
| H | GLU132 |
| H | GLU134 |
| H | GLU189 |
| H | GLU196 |
| H | GLY241 |
| H | GLY243 |
| H | HIS245 |
| H | ARG298 |
| H | GLU304 |
| H | ARG316 |
| H | ARG335 |
| H | ADP602 |
| H | MG603 |
| H | MG604 |
| H | MG605 |
| H | HOH713 |
| H | HOH728 |
| H | HOH757 |
| H | HOH840 |
| site_id | EC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE ADP H 602 |
| Chain | Residue |
| H | GLY130 |
| H | GLU132 |
| H | GLU184 |
| H | GLU196 |
| H | ASP198 |
| H | PHE199 |
| H | LYS200 |
| H | TYR201 |
| H | ASN247 |
| H | SER249 |
| H | ASN256 |
| H | ARG321 |
| H | ILE328 |
| H | ARG331 |
| H | GLU333 |
| H | P3S601 |
| H | MG604 |
| H | MG605 |
| H | HOH704 |
| H | HOH725 |
| H | HOH733 |
| H | HOH800 |
| H | HOH874 |
| site_id | EC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG H 603 |
| Chain | Residue |
| H | GLU134 |
| H | GLU189 |
| H | GLU196 |
| H | P3S601 |
| H | HOH713 |
| H | HOH840 |
| site_id | EC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG H 604 |
| Chain | Residue |
| H | GLU132 |
| H | HIS245 |
| H | GLU333 |
| H | ARG335 |
| H | P3S601 |
| H | ADP602 |
| site_id | EC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG H 605 |
| Chain | Residue |
| H | GLU132 |
| H | GLU196 |
| H | P3S601 |
| H | ADP602 |
| H | HOH725 |
| H | HOH840 |
| site_id | EC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE P3S I 501 |
| Chain | Residue |
| H | ASP53 |
| I | GLU132 |
| I | GLU134 |
| I | GLU189 |
| I | VAL190 |
| I | GLU196 |
| I | GLY241 |
| I | HIS245 |
| I | ARG298 |
| I | GLU304 |
| I | ALA305 |
| I | ARG316 |
| I | ARG335 |
| I | ADP502 |
| I | MG503 |
| I | MG504 |
| I | MG505 |
| I | HOH633 |
| I | HOH641 |
| I | HOH642 |
| I | HOH664 |
| site_id | EC6 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ADP I 502 |
| Chain | Residue |
| I | ASN128 |
| I | GLY130 |
| I | GLU132 |
| I | GLU184 |
| I | GLU196 |
| I | ASP198 |
| I | PHE199 |
| I | LYS200 |
| I | TYR201 |
| I | ASN247 |
| I | SER249 |
| I | ASN256 |
| I | ARG321 |
| I | ILE328 |
| I | ARG331 |
| I | GLU333 |
| I | P3S501 |
| I | MG504 |
| I | MG505 |
| I | HOH607 |
| I | HOH661 |
| I | HOH701 |
| site_id | EC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG I 503 |
| Chain | Residue |
| I | GLU134 |
| I | GLU189 |
| I | GLU196 |
| I | P3S501 |
| I | HOH641 |
| site_id | EC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG I 504 |
| Chain | Residue |
| I | GLU132 |
| I | HIS245 |
| I | GLU333 |
| I | P3S501 |
| I | ADP502 |
| site_id | EC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG I 505 |
| Chain | Residue |
| I | GLU132 |
| I | GLU196 |
| I | P3S501 |
| I | ADP502 |
| I | HOH661 |
| site_id | FC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE P3S J 501 |
| Chain | Residue |
| J | GLU132 |
| J | GLU134 |
| J | GLU189 |
| J | VAL190 |
| J | GLY241 |
| J | HIS245 |
| J | ARG298 |
| J | GLU304 |
| J | ARG316 |
| J | ARG335 |
| J | ADP502 |
| J | MG503 |
| J | MG504 |
| J | MG505 |
| J | HOH602 |
| J | HOH650 |
| J | HOH704 |
| J | HOH719 |
| site_id | FC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ADP J 502 |
| Chain | Residue |
| J | GLY130 |
| J | GLU132 |
| J | GLU184 |
| J | GLU196 |
| J | ASP198 |
| J | PHE199 |
| J | LYS200 |
| J | TYR201 |
| J | ASN247 |
| J | SER249 |
| J | ASN256 |
| J | ARG321 |
| J | ILE328 |
| J | SER329 |
| J | ARG331 |
| J | GLU333 |
| J | P3S501 |
| J | MG504 |
| J | MG505 |
| J | HOH642 |
| J | HOH658 |
| J | HOH676 |
| site_id | FC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG J 503 |
| Chain | Residue |
| J | GLU134 |
| J | GLU189 |
| J | GLU196 |
| J | P3S501 |
| J | HOH704 |
| site_id | FC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG J 504 |
| Chain | Residue |
| J | GLU132 |
| J | HIS245 |
| J | GLU333 |
| J | P3S501 |
| J | ADP502 |
| site_id | FC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG J 505 |
| Chain | Residue |
| J | GLU132 |
| J | GLU196 |
| J | ASP198 |
| J | P3S501 |
| J | ADP502 |
| J | HOH658 |
| site_id | FC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE P3S K 501 |
| Chain | Residue |
| K | GLU132 |
| K | GLU134 |
| K | GLU189 |
| K | GLY241 |
| K | HIS245 |
| K | ARG298 |
| K | GLU304 |
| K | ALA305 |
| K | ARG316 |
| K | ARG335 |
| K | ADP502 |
| K | MG503 |
| K | MG504 |
| K | MG505 |
| K | HOH609 |
| K | HOH654 |
| K | HOH686 |
| site_id | FC7 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP K 502 |
| Chain | Residue |
| K | GLY130 |
| K | GLU132 |
| K | GLU184 |
| K | GLU196 |
| K | ASP198 |
| K | PHE199 |
| K | LYS200 |
| K | TYR201 |
| K | ASN247 |
| K | SER249 |
| K | ASN256 |
| K | ARG321 |
| K | ILE328 |
| K | ARG331 |
| K | GLU333 |
| K | P3S501 |
| K | MG504 |
| K | MG505 |
| K | HOH604 |
| K | HOH614 |
| K | HOH704 |
| site_id | FC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG K 503 |
| Chain | Residue |
| K | GLU134 |
| K | GLU189 |
| K | GLU196 |
| K | P3S501 |
| K | MG505 |
| K | HOH663 |
| site_id | FC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG K 504 |
| Chain | Residue |
| K | GLU132 |
| K | HIS245 |
| K | GLU333 |
| K | P3S501 |
| K | ADP502 |
| site_id | GC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG K 505 |
| Chain | Residue |
| K | GLU132 |
| K | GLU196 |
| K | P3S501 |
| K | ADP502 |
| K | MG503 |
| K | HOH614 |
| site_id | GC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE P3S L 501 |
| Chain | Residue |
| L | GLU132 |
| L | GLU134 |
| L | GLU189 |
| L | VAL190 |
| L | GLU196 |
| L | GLY241 |
| L | GLY243 |
| L | HIS245 |
| L | ARG298 |
| L | GLU304 |
| L | ARG316 |
| L | ARG335 |
| L | ADP502 |
| L | MG503 |
| L | MG504 |
| L | MG505 |
| L | HOH638 |
| L | HOH698 |
| L | HOH733 |
| site_id | GC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ADP L 502 |
| Chain | Residue |
| L | GLY130 |
| L | GLU132 |
| L | GLU184 |
| L | GLU196 |
| L | ASP198 |
| L | PHE199 |
| L | LYS200 |
| L | TYR201 |
| L | ASN247 |
| L | SER249 |
| L | ASN256 |
| L | ARG321 |
| L | ILE328 |
| L | ARG331 |
| L | GLU333 |
| L | P3S501 |
| L | MG504 |
| L | MG505 |
| L | HOH618 |
| L | HOH729 |
| site_id | GC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG L 503 |
| Chain | Residue |
| L | GLU134 |
| L | GLU189 |
| L | GLU196 |
| L | P3S501 |
| L | HOH698 |
| site_id | GC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG L 504 |
| Chain | Residue |
| L | GLU132 |
| L | HIS245 |
| L | GLU333 |
| L | P3S501 |
| L | ADP502 |
| site_id | GC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG L 505 |
| Chain | Residue |
| L | GLU132 |
| L | GLU196 |
| L | P3S501 |
| L | ADP502 |
| L | HOH654 |
Functional Information from PROSITE/UniProt
| site_id | PS00180 |
| Number of Residues | 19 |
| Details | GLNA_1 Glutamine synthetase signature 1. FDGSSiegfvrieESDmyL |
| Chain | Residue | Details |
| A | PHE52-LEU70 |
| site_id | PS00181 |
| Number of Residues | 16 |
| Details | GLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPLfgv..NGSGmHcnlS |
| Chain | Residue | Details |
| A | LYS234-SER249 |
| site_id | PS00182 |
| Number of Residues | 13 |
| Details | GLNA_ADENYLATION Glutamine synthetase class-I adenylation site. KLeapapIDRNIY |
| Chain | Residue | Details |
| A | LYS361-TYR373 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1020 |
| Details | Domain: {"description":"GS beta-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU01330","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4032 |
| Details | Domain: {"description":"GS catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU01331","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24158439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25691471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LNI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4S0R","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24158439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25691471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LNI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4S0R","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P9WN39","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24158439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25691471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4S0R","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24158439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25691471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4S0R","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P77961","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P0A1P6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | Site: {"description":"Important for inhibition by glutamine","evidences":[{"source":"PubMed","id":"24158439","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
