4LNF
B. subtilis glutamine synthetase structures reveal large active site conformational changes and basis for isoenzyme specific regulation: structure of GS-Q
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004356 | molecular_function | glutamine synthetase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006542 | biological_process | glutamine biosynthetic process |
| A | 0016595 | molecular_function | glutamate binding |
| A | 0016874 | molecular_function | ligase activity |
| A | 0043562 | biological_process | cellular response to nitrogen levels |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070406 | molecular_function | glutamine binding |
| A | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| A | 0140297 | molecular_function | DNA-binding transcription factor binding |
| A | 1904797 | biological_process | negative regulation of core promoter binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004356 | molecular_function | glutamine synthetase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006542 | biological_process | glutamine biosynthetic process |
| B | 0016595 | molecular_function | glutamate binding |
| B | 0016874 | molecular_function | ligase activity |
| B | 0043562 | biological_process | cellular response to nitrogen levels |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070406 | molecular_function | glutamine binding |
| B | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| B | 0140297 | molecular_function | DNA-binding transcription factor binding |
| B | 1904797 | biological_process | negative regulation of core promoter binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004356 | molecular_function | glutamine synthetase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006542 | biological_process | glutamine biosynthetic process |
| C | 0016595 | molecular_function | glutamate binding |
| C | 0016874 | molecular_function | ligase activity |
| C | 0043562 | biological_process | cellular response to nitrogen levels |
| C | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070406 | molecular_function | glutamine binding |
| C | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| C | 0140297 | molecular_function | DNA-binding transcription factor binding |
| C | 1904797 | biological_process | negative regulation of core promoter binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004356 | molecular_function | glutamine synthetase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006542 | biological_process | glutamine biosynthetic process |
| D | 0016595 | molecular_function | glutamate binding |
| D | 0016874 | molecular_function | ligase activity |
| D | 0043562 | biological_process | cellular response to nitrogen levels |
| D | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070406 | molecular_function | glutamine binding |
| D | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| D | 0140297 | molecular_function | DNA-binding transcription factor binding |
| D | 1904797 | biological_process | negative regulation of core promoter binding |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004356 | molecular_function | glutamine synthetase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006542 | biological_process | glutamine biosynthetic process |
| E | 0016595 | molecular_function | glutamate binding |
| E | 0016874 | molecular_function | ligase activity |
| E | 0043562 | biological_process | cellular response to nitrogen levels |
| E | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070406 | molecular_function | glutamine binding |
| E | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| E | 0140297 | molecular_function | DNA-binding transcription factor binding |
| E | 1904797 | biological_process | negative regulation of core promoter binding |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004356 | molecular_function | glutamine synthetase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006542 | biological_process | glutamine biosynthetic process |
| F | 0016595 | molecular_function | glutamate binding |
| F | 0016874 | molecular_function | ligase activity |
| F | 0043562 | biological_process | cellular response to nitrogen levels |
| F | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070406 | molecular_function | glutamine binding |
| F | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| F | 0140297 | molecular_function | DNA-binding transcription factor binding |
| F | 1904797 | biological_process | negative regulation of core promoter binding |
| G | 0000287 | molecular_function | magnesium ion binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004356 | molecular_function | glutamine synthetase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006542 | biological_process | glutamine biosynthetic process |
| G | 0016595 | molecular_function | glutamate binding |
| G | 0016874 | molecular_function | ligase activity |
| G | 0043562 | biological_process | cellular response to nitrogen levels |
| G | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0070406 | molecular_function | glutamine binding |
| G | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| G | 0140297 | molecular_function | DNA-binding transcription factor binding |
| G | 1904797 | biological_process | negative regulation of core promoter binding |
| H | 0000287 | molecular_function | magnesium ion binding |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004356 | molecular_function | glutamine synthetase activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006542 | biological_process | glutamine biosynthetic process |
| H | 0016595 | molecular_function | glutamate binding |
| H | 0016874 | molecular_function | ligase activity |
| H | 0043562 | biological_process | cellular response to nitrogen levels |
| H | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0070406 | molecular_function | glutamine binding |
| H | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| H | 0140297 | molecular_function | DNA-binding transcription factor binding |
| H | 1904797 | biological_process | negative regulation of core promoter binding |
| I | 0000287 | molecular_function | magnesium ion binding |
| I | 0003824 | molecular_function | catalytic activity |
| I | 0004356 | molecular_function | glutamine synthetase activity |
| I | 0005515 | molecular_function | protein binding |
| I | 0005524 | molecular_function | ATP binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0006542 | biological_process | glutamine biosynthetic process |
| I | 0016595 | molecular_function | glutamate binding |
| I | 0016874 | molecular_function | ligase activity |
| I | 0043562 | biological_process | cellular response to nitrogen levels |
| I | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| I | 0046872 | molecular_function | metal ion binding |
| I | 0070406 | molecular_function | glutamine binding |
| I | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| I | 0140297 | molecular_function | DNA-binding transcription factor binding |
| I | 1904797 | biological_process | negative regulation of core promoter binding |
| J | 0000287 | molecular_function | magnesium ion binding |
| J | 0003824 | molecular_function | catalytic activity |
| J | 0004356 | molecular_function | glutamine synthetase activity |
| J | 0005515 | molecular_function | protein binding |
| J | 0005524 | molecular_function | ATP binding |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0006542 | biological_process | glutamine biosynthetic process |
| J | 0016595 | molecular_function | glutamate binding |
| J | 0016874 | molecular_function | ligase activity |
| J | 0043562 | biological_process | cellular response to nitrogen levels |
| J | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0070406 | molecular_function | glutamine binding |
| J | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| J | 0140297 | molecular_function | DNA-binding transcription factor binding |
| J | 1904797 | biological_process | negative regulation of core promoter binding |
| K | 0000287 | molecular_function | magnesium ion binding |
| K | 0003824 | molecular_function | catalytic activity |
| K | 0004356 | molecular_function | glutamine synthetase activity |
| K | 0005515 | molecular_function | protein binding |
| K | 0005524 | molecular_function | ATP binding |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0006542 | biological_process | glutamine biosynthetic process |
| K | 0016595 | molecular_function | glutamate binding |
| K | 0016874 | molecular_function | ligase activity |
| K | 0043562 | biological_process | cellular response to nitrogen levels |
| K | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| K | 0046872 | molecular_function | metal ion binding |
| K | 0070406 | molecular_function | glutamine binding |
| K | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| K | 0140297 | molecular_function | DNA-binding transcription factor binding |
| K | 1904797 | biological_process | negative regulation of core promoter binding |
| L | 0000287 | molecular_function | magnesium ion binding |
| L | 0003824 | molecular_function | catalytic activity |
| L | 0004356 | molecular_function | glutamine synthetase activity |
| L | 0005515 | molecular_function | protein binding |
| L | 0005524 | molecular_function | ATP binding |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0006542 | biological_process | glutamine biosynthetic process |
| L | 0016595 | molecular_function | glutamate binding |
| L | 0016874 | molecular_function | ligase activity |
| L | 0043562 | biological_process | cellular response to nitrogen levels |
| L | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0070406 | molecular_function | glutamine binding |
| L | 0090295 | biological_process | nitrogen catabolite repression of transcription |
| L | 0140297 | molecular_function | DNA-binding transcription factor binding |
| L | 1904797 | biological_process | negative regulation of core promoter binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 501 |
| Chain | Residue |
| A | GLU134 |
| A | GLU189 |
| A | GLU196 |
| A | GLN503 |
| A | PO4504 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 502 |
| Chain | Residue |
| A | GLU132 |
| A | HIS245 |
| A | GLU333 |
| A | PO4504 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GLN A 503 |
| Chain | Residue |
| A | GLU134 |
| A | TYR156 |
| A | GLU189 |
| A | GLN194 |
| A | ASN240 |
| A | GLY241 |
| A | ARG298 |
| A | GLU304 |
| A | MG501 |
| A | PO4504 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 504 |
| Chain | Residue |
| A | GLU132 |
| A | GLU134 |
| A | GLU196 |
| A | HIS245 |
| A | MG501 |
| A | MG502 |
| A | GLN503 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG A 505 |
| Chain | Residue |
| A | HIS416 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 501 |
| Chain | Residue |
| B | GLU134 |
| B | GLU189 |
| B | GLU196 |
| B | GLN503 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 502 |
| Chain | Residue |
| B | GLU132 |
| B | HIS245 |
| B | GLU333 |
| B | HOH603 |
| C | GLU65 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GLN B 503 |
| Chain | Residue |
| B | GLU134 |
| B | GLU189 |
| B | GLN194 |
| B | ASN240 |
| B | GLY241 |
| B | HIS245 |
| B | ARG298 |
| B | GLU304 |
| B | ARG335 |
| B | MG501 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG B 504 |
| Chain | Residue |
| B | GLU58 |
| B | HIS416 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 501 |
| Chain | Residue |
| C | GLU134 |
| C | GLU189 |
| C | GLU196 |
| C | GLN502 |
| C | PO4504 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GLN C 502 |
| Chain | Residue |
| C | GLU134 |
| C | TYR156 |
| C | GLU189 |
| C | GLY241 |
| C | SER242 |
| C | GLY243 |
| C | HIS245 |
| C | ARG298 |
| C | GLU304 |
| C | MG501 |
| C | PO4504 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 503 |
| Chain | Residue |
| C | GLU132 |
| C | HIS245 |
| C | ARG321 |
| C | GLU333 |
| C | PO4504 |
| D | GLU65 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 C 504 |
| Chain | Residue |
| C | GLU132 |
| C | GLU134 |
| C | GLU196 |
| C | HIS245 |
| C | GLU333 |
| C | MG501 |
| C | GLN502 |
| C | MG503 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG C 505 |
| Chain | Residue |
| C | HIS416 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 501 |
| Chain | Residue |
| D | GLU134 |
| D | GLU189 |
| D | GLU196 |
| D | GLN503 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG D 502 |
| Chain | Residue |
| D | GLU132 |
| D | HIS245 |
| D | GLU333 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GLN D 503 |
| Chain | Residue |
| D | GLU134 |
| D | GLU189 |
| D | GLY241 |
| D | HIS245 |
| D | ARG298 |
| D | GLU304 |
| D | MG501 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG D 504 |
| Chain | Residue |
| D | GLU58 |
| D | HIS416 |
| D | HOH605 |
| site_id | CC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GLN E 501 |
| Chain | Residue |
| E | GLN194 |
| E | GLU196 |
| E | ASN240 |
| E | GLY241 |
| E | GLY243 |
| E | ARG298 |
| E | GLU304 |
| E | MG503 |
| E | HOH603 |
| E | GLU134 |
| E | TYR156 |
| E | GLU189 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG E 502 |
| Chain | Residue |
| E | GLU132 |
| E | HIS245 |
| E | GLU333 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG E 503 |
| Chain | Residue |
| E | GLU134 |
| E | GLU189 |
| E | GLU196 |
| E | GLN501 |
| E | HOH603 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG E 504 |
| Chain | Residue |
| E | GLU58 |
| E | HIS416 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG F 501 |
| Chain | Residue |
| F | GLU132 |
| F | HIS245 |
| F | GLU333 |
| F | HOH616 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG F 502 |
| Chain | Residue |
| F | GLU134 |
| F | GLU189 |
| F | GLU196 |
| F | GLN503 |
| site_id | CC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GLN F 503 |
| Chain | Residue |
| F | GLU134 |
| F | TYR156 |
| F | GLU189 |
| F | ASN240 |
| F | GLY241 |
| F | GLY243 |
| F | HIS245 |
| F | ARG298 |
| F | GLU304 |
| F | MG502 |
| site_id | CC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG F 504 |
| Chain | Residue |
| F | GLU58 |
| F | HIS416 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG G 501 |
| Chain | Residue |
| G | GLU134 |
| G | GLU189 |
| G | GLU196 |
| G | GLN503 |
| G | PO4504 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG G 502 |
| Chain | Residue |
| G | GLU132 |
| G | HIS245 |
| G | GLU333 |
| G | PO4504 |
| L | GLU65 |
| site_id | DC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GLN G 503 |
| Chain | Residue |
| G | GLU134 |
| G | GLU189 |
| G | GLY241 |
| G | GLY243 |
| G | HIS245 |
| G | ARG298 |
| G | GLU304 |
| G | MG501 |
| G | PO4504 |
| site_id | DC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 G 504 |
| Chain | Residue |
| G | GLU132 |
| G | GLU134 |
| G | GLU196 |
| G | HIS245 |
| G | GLU333 |
| G | MG501 |
| G | MG502 |
| G | GLN503 |
| site_id | DC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG G 505 |
| Chain | Residue |
| G | GLU58 |
| G | HIS416 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG H 501 |
| Chain | Residue |
| H | GLU134 |
| H | GLU189 |
| H | GLU196 |
| H | GLN503 |
| H | PO4504 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG H 502 |
| Chain | Residue |
| H | GLU132 |
| H | HIS245 |
| H | GLU333 |
| H | PO4504 |
| site_id | DC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GLN H 503 |
| Chain | Residue |
| H | GLU134 |
| H | TYR156 |
| H | GLU189 |
| H | GLU196 |
| H | GLY241 |
| H | ARG298 |
| H | GLU304 |
| H | ALA305 |
| H | MG501 |
| H | PO4504 |
| H | HOH601 |
| site_id | DC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 H 504 |
| Chain | Residue |
| G | GLU65 |
| H | GLU132 |
| H | TYR156 |
| H | GLU196 |
| H | HIS245 |
| H | GLU333 |
| H | MG501 |
| H | MG502 |
| H | GLN503 |
| site_id | DC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG H 505 |
| Chain | Residue |
| H | GLU58 |
| H | HIS416 |
| site_id | EC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG I 501 |
| Chain | Residue |
| I | GLU134 |
| I | GLU189 |
| I | GLU196 |
| I | GLN503 |
| site_id | EC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG I 502 |
| Chain | Residue |
| H | HOH602 |
| I | GLU132 |
| I | HIS245 |
| I | GLU333 |
| site_id | EC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GLN I 503 |
| Chain | Residue |
| I | GLU134 |
| I | TYR156 |
| I | GLU189 |
| I | ASN240 |
| I | GLY241 |
| I | HIS245 |
| I | ARG298 |
| I | GLU304 |
| I | MG501 |
| site_id | EC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG I 504 |
| Chain | Residue |
| I | GLU58 |
| I | HIS416 |
| site_id | EC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG J 501 |
| Chain | Residue |
| J | GLU134 |
| J | GLU189 |
| J | GLU196 |
| J | GLN503 |
| site_id | EC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG J 502 |
| Chain | Residue |
| J | GLU132 |
| J | HIS245 |
| J | GLU333 |
| site_id | EC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GLN J 503 |
| Chain | Residue |
| I | ARG62 |
| J | GLU134 |
| J | TYR156 |
| J | GLU189 |
| J | ASN240 |
| J | GLY241 |
| J | HIS245 |
| J | ARG298 |
| J | GLU304 |
| J | MG501 |
| site_id | EC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG J 504 |
| Chain | Residue |
| J | HIS416 |
| site_id | EC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG K 501 |
| Chain | Residue |
| K | GLU134 |
| K | GLU189 |
| K | GLU196 |
| K | GLN503 |
| site_id | FC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG K 502 |
| Chain | Residue |
| J | GLU65 |
| K | GLU132 |
| K | HIS245 |
| K | GLU333 |
| site_id | FC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GLN K 503 |
| Chain | Residue |
| K | GLU134 |
| K | TYR156 |
| K | GLU189 |
| K | GLY241 |
| K | ARG298 |
| K | GLU304 |
| K | ALA305 |
| K | MG501 |
| K | HOH602 |
| site_id | FC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG K 504 |
| Chain | Residue |
| K | GLU58 |
| K | HIS416 |
| site_id | FC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG L 501 |
| Chain | Residue |
| L | GLU134 |
| L | GLU189 |
| L | GLU196 |
| L | MG502 |
| L | GLN503 |
| site_id | FC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG L 502 |
| Chain | Residue |
| L | GLU132 |
| L | HIS245 |
| L | GLU333 |
| L | MG501 |
| L | GLN503 |
| L | HOH602 |
| site_id | FC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GLN L 503 |
| Chain | Residue |
| L | GLU134 |
| L | GLU189 |
| L | GLY241 |
| L | HIS245 |
| L | ARG298 |
| L | MG501 |
| L | MG502 |
| L | HOH615 |
| site_id | FC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG L 504 |
| Chain | Residue |
| L | HIS416 |
| L | HOH621 |
Functional Information from PROSITE/UniProt
| site_id | PS00180 |
| Number of Residues | 19 |
| Details | GLNA_1 Glutamine synthetase signature 1. FDGSSiegfvrieESDmyL |
| Chain | Residue | Details |
| A | PHE52-LEU70 |
| site_id | PS00181 |
| Number of Residues | 16 |
| Details | GLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPLfgv..NGSGmHcnlS |
| Chain | Residue | Details |
| A | LYS234-SER249 |
| site_id | PS00182 |
| Number of Residues | 13 |
| Details | GLNA_ADENYLATION Glutamine synthetase class-I adenylation site. KLeapapIDRNIY |
| Chain | Residue | Details |
| A | LYS361-TYR373 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24158439, ECO:0000269|PubMed:25691471, ECO:0007744|PDB:4LNF, ECO:0007744|PDB:4LNI, ECO:0007744|PDB:4LNK, ECO:0007744|PDB:4LNN, ECO:0007744|PDB:4S0R |
| Chain | Residue | Details |
| A | GLU132 | |
| E | GLU333 | |
| F | GLU132 | |
| F | GLU333 | |
| G | GLU132 | |
| G | GLU333 | |
| H | GLU132 | |
| H | GLU333 | |
| I | GLU132 | |
| I | GLU333 | |
| J | GLU132 | |
| A | GLU333 | |
| J | GLU333 | |
| K | GLU132 | |
| K | GLU333 | |
| L | GLU132 | |
| L | GLU333 | |
| B | GLU132 | |
| B | GLU333 | |
| C | GLU132 | |
| C | GLU333 | |
| D | GLU132 | |
| D | GLU333 | |
| E | GLU132 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24158439, ECO:0000269|PubMed:25691471, ECO:0007744|PDB:4LNF, ECO:0007744|PDB:4LNI, ECO:0007744|PDB:4LNK, ECO:0007744|PDB:4S0R |
| Chain | Residue | Details |
| A | GLU134 | |
| D | GLU134 | |
| D | GLU189 | |
| D | GLU196 | |
| E | GLU134 | |
| E | GLU189 | |
| E | GLU196 | |
| F | GLU134 | |
| F | GLU189 | |
| F | GLU196 | |
| G | GLU134 | |
| A | GLU189 | |
| G | GLU189 | |
| G | GLU196 | |
| H | GLU134 | |
| H | GLU189 | |
| H | GLU196 | |
| I | GLU134 | |
| I | GLU189 | |
| I | GLU196 | |
| J | GLU134 | |
| J | GLU189 | |
| A | GLU196 | |
| J | GLU196 | |
| K | GLU134 | |
| K | GLU189 | |
| K | GLU196 | |
| L | GLU134 | |
| L | GLU189 | |
| L | GLU196 | |
| B | GLU134 | |
| B | GLU189 | |
| B | GLU196 | |
| C | GLU134 | |
| C | GLU189 | |
| C | GLU196 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P9WN39 |
| Chain | Residue | Details |
| A | GLU184 | |
| C | ASN240 | |
| C | ARG316 | |
| C | ARG321 | |
| D | GLU184 | |
| D | ASN240 | |
| D | ARG316 | |
| D | ARG321 | |
| E | GLU184 | |
| E | ASN240 | |
| E | ARG316 | |
| A | ASN240 | |
| E | ARG321 | |
| F | GLU184 | |
| F | ASN240 | |
| F | ARG316 | |
| F | ARG321 | |
| G | GLU184 | |
| G | ASN240 | |
| G | ARG316 | |
| G | ARG321 | |
| H | GLU184 | |
| A | ARG316 | |
| H | ASN240 | |
| H | ARG316 | |
| H | ARG321 | |
| I | GLU184 | |
| I | ASN240 | |
| I | ARG316 | |
| I | ARG321 | |
| J | GLU184 | |
| J | ASN240 | |
| J | ARG316 | |
| A | ARG321 | |
| J | ARG321 | |
| K | GLU184 | |
| K | ASN240 | |
| K | ARG316 | |
| K | ARG321 | |
| L | GLU184 | |
| L | ASN240 | |
| L | ARG316 | |
| L | ARG321 | |
| B | GLU184 | |
| B | ASN240 | |
| B | ARG316 | |
| B | ARG321 | |
| C | GLU184 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24158439, ECO:0000269|PubMed:25691471, ECO:0007744|PDB:4LNF, ECO:0007744|PDB:4LNK, ECO:0007744|PDB:4LNN, ECO:0007744|PDB:4S0R |
| Chain | Residue | Details |
| A | GLY241 | |
| J | GLY241 | |
| K | GLY241 | |
| L | GLY241 | |
| B | GLY241 | |
| C | GLY241 | |
| D | GLY241 | |
| E | GLY241 | |
| F | GLY241 | |
| G | GLY241 | |
| H | GLY241 | |
| I | GLY241 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24158439, ECO:0000269|PubMed:25691471, ECO:0007744|PDB:4LNF, ECO:0007744|PDB:4LNK, ECO:0007744|PDB:4S0R |
| Chain | Residue | Details |
| A | HIS245 | |
| J | HIS245 | |
| K | HIS245 | |
| L | HIS245 | |
| B | HIS245 | |
| C | HIS245 | |
| D | HIS245 | |
| E | HIS245 | |
| F | HIS245 | |
| G | HIS245 | |
| H | HIS245 | |
| I | HIS245 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P77961 |
| Chain | Residue | Details |
| A | SER249 | |
| J | SER249 | |
| K | SER249 | |
| L | SER249 | |
| B | SER249 | |
| C | SER249 | |
| D | SER249 | |
| E | SER249 | |
| F | SER249 | |
| G | SER249 | |
| H | SER249 | |
| I | SER249 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 36 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0A1P6 |
| Chain | Residue | Details |
| A | ARG298 | |
| D | ARG298 | |
| D | GLU304 | |
| D | ARG335 | |
| E | ARG298 | |
| E | GLU304 | |
| E | ARG335 | |
| F | ARG298 | |
| F | GLU304 | |
| F | ARG335 | |
| G | ARG298 | |
| A | GLU304 | |
| G | GLU304 | |
| G | ARG335 | |
| H | ARG298 | |
| H | GLU304 | |
| H | ARG335 | |
| I | ARG298 | |
| I | GLU304 | |
| I | ARG335 | |
| J | ARG298 | |
| J | GLU304 | |
| A | ARG335 | |
| J | ARG335 | |
| K | ARG298 | |
| K | GLU304 | |
| K | ARG335 | |
| L | ARG298 | |
| L | GLU304 | |
| L | ARG335 | |
| B | ARG298 | |
| B | GLU304 | |
| B | ARG335 | |
| C | ARG298 | |
| C | GLU304 | |
| C | ARG335 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | SITE: Important for inhibition by glutamine => ECO:0000269|PubMed:24158439 |
| Chain | Residue | Details |
| A | ARG62 | |
| J | ARG62 | |
| K | ARG62 | |
| L | ARG62 | |
| B | ARG62 | |
| C | ARG62 | |
| D | ARG62 | |
| E | ARG62 | |
| F | ARG62 | |
| G | ARG62 | |
| H | ARG62 | |
| I | ARG62 |
