4LN1

CRYSTAL STRUCTURE OF L-lactate dehydrogenase from Bacillus cereus ATCC 14579 complexed with calcium, NYSGRC Target 029452

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
A	0005737	cellular_component	cytoplasm
A	0006089	biological_process	lactate metabolic process
A	0006096	biological_process	glycolytic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
A	0042867	biological_process	pyruvate catabolic process
B	0003824	molecular_function	catalytic activity
B	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
B	0005737	cellular_component	cytoplasm
B	0006089	biological_process	lactate metabolic process
B	0006096	biological_process	glycolytic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019752	biological_process	carboxylic acid metabolic process
B	0042867	biological_process	pyruvate catabolic process
C	0003824	molecular_function	catalytic activity
C	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
C	0005737	cellular_component	cytoplasm
C	0006089	biological_process	lactate metabolic process
C	0006096	biological_process	glycolytic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019752	biological_process	carboxylic acid metabolic process
C	0042867	biological_process	pyruvate catabolic process
D	0003824	molecular_function	catalytic activity
D	0004459	molecular_function	L-lactate dehydrogenase (NAD+) activity
D	0005737	cellular_component	cytoplasm
D	0006089	biological_process	lactate metabolic process
D	0006096	biological_process	glycolytic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019752	biological_process	carboxylic acid metabolic process
D	0042867	biological_process	pyruvate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CA A 500

Chain	Residue
A	HOH624
A	HOH650
A	HOH684
A	HOH686
C	HOH622
C	HOH632
C	HOH648
C	HOH649

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 501

Chain	Residue
A	ILE5
A	ASP75
A	HOH654
A	HOH672
A	HOH688
A	HOH689
A	LYS3

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 500

Chain	Residue
B	HOH627
B	HOH643
D	HOH627
D	HOH642
D	HOH662

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 501

Chain	Residue
B	LYS3
B	ILE5
B	ASP75
B	HOH650
B	HOH657

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA C 501

Chain	Residue
C	LYS3
C	ILE5
C	ASP75
C	HOH650
C	HOH655
C	HOH664
C	HOH672

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA D 501

Chain	Residue
D	LYS3
D	ILE5
D	ASP75
D	HOH643
D	HOH653
D	HOH670
D	HOH674

---

Functional Information from PROSITE/UniProt

site_id	PS00064
Number of Residues	7
Details	L_LDH L-lactate dehydrogenase active site. IGEHGDT

Chain	Residue	Details
A	ILE175-THR181

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00488","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	76
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00488","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"HAMAP-Rule","id":"MF_00488","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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