Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4LMJ

GLIC Liganded-closed-channel Conformation, Mutant T25'A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005267	molecular_function	potassium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0071805	biological_process	potassium ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005267	molecular_function	potassium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0006814	biological_process	sodium ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0071805	biological_process	potassium ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005267	molecular_function	potassium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0006814	biological_process	sodium ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0071805	biological_process	potassium ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005267	molecular_function	potassium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0006814	biological_process	sodium ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0071805	biological_process	potassium ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005267	molecular_function	potassium channel activity
E	0005272	molecular_function	sodium channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006813	biological_process	potassium ion transport
E	0006814	biological_process	sodium ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035725	biological_process	sodium ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 401

Chain	Residue
E	SER219
E	TYR220

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT E 402

Chain	Residue
D	ILE232
E	ILE239

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA B 401

Chain	Residue
B	GLU242
C	ILE239
C	GLU242

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 402

Chain	Residue
B	SER219
B	TYR220

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA B 403

Chain	Residue
A	GLU242
B	ILE239
B	GLU242

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA C 401

Chain	Residue
C	GLU242
D	GLU242

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 402

Chain	Residue
C	SER219
C	TYR220

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 401

Chain	Residue
A	ILE239
A	GLU242
E	GLU242

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 402

Chain	Residue
A	TYR220

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA D 401

Chain	Residue
D	GLU242
E	ILE239
E	GLU242

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 402

Chain	Residue
D	SER219
D	TYR220

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	990
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
E	GLN1-GLN192
D	ASN244-MET251
E	ASN244-MET251
B	GLN1-GLN192
B	ASN244-MET251
C	GLN1-GLN192
C	ASN244-MET251
A	GLN1-GLN192
A	ASN244-MET251
D	GLN1-GLN192

site_id	SWS_FT_FI2
Number of Residues	530
Details	TRANSMEM: Helical

Chain	Residue	Details
E	TYR193-PHE215
C	SER219-THR243
C	THR252-VAL280
C	PRO284-PHE316
A	TYR193-PHE215
A	SER219-THR243
A	THR252-VAL280
A	PRO284-PHE316
D	TYR193-PHE215
D	SER219-THR243
D	THR252-VAL280
E	SER219-THR243
D	PRO284-PHE316
E	THR252-VAL280
E	PRO284-PHE316
B	TYR193-PHE215
B	SER219-THR243
B	THR252-VAL280
B	PRO284-PHE316
C	TYR193-PHE215

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
E	TRP216-THR218
D	GLU281-GLN283
E	GLU281-GLN283
B	TRP216-THR218
B	GLU281-GLN283
C	TRP216-THR218
C	GLU281-GLN283
A	TRP216-THR218
A	GLU281-GLN283
D	TRP216-THR218

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)