4LLB

Crystal Structure of MOZ double PHD finger histone H3K14ac complex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0030527	molecular_function	structural constituent of chromatin
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0030527	molecular_function	structural constituent of chromatin

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	CYS281
A	CYS284
A	CYS307
A	CYS310

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 402

Chain	Residue
A	CYS265
A	CYS268
A	HIS289
A	CYS292

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 403

Chain	Residue
A	CYS212
A	HIS238
A	CYS241
A	CYS209

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 404

Chain	Residue
A	CYS230
A	CYS233
A	CYS259
A	CYS262

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 401

Chain	Residue
B	CYS281
B	CYS284
B	CYS307
B	CYS310

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 402

Chain	Residue
B	CYS265
B	CYS268
B	HIS289
B	CYS292

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 403

Chain	Residue
B	CYS209
B	CYS212
B	HIS238
B	CYS241

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 404

Chain	Residue
B	CYS230
B	CYS233
B	CYS259
B	CYS262

---

site_id	AC9
Number of Residues	56
Details	BINDING SITE FOR CHAIN B OF HISTONE ACETYLTRANSFERASE KAT6A

Chain	Residue
A	GLU221
A	VAL250
B	LEU192
B	LEU192
B	GLU193
B	ZN401
B	ZN402
B	ZN403
B	ZN404
B	HOH501
B	HOH502
B	HOH503
B	HOH504
B	HOH505
B	HOH506
B	HOH508
B	HOH509
B	HOH510
B	HOH511
B	HOH511
B	HOH512
B	HOH513
B	HOH515
B	HOH518
B	HOH519
B	HOH520
B	HOH522
B	HOH523
B	HOH524
B	HOH525
B	HOH526
B	HOH528
B	HOH530
B	HOH532
B	HOH533
B	HOH535
B	HOH538
B	HOH539
B	HOH540
B	HOH541
B	HOH542
B	HOH543
B	HOH558
D	ALA1
D	ARG2
D	THR3
D	LYS4
D	GLN5
D	ALA7
D	ARG8
D	SER10
D	THR11
D	GLY13
D	ALY14
D	ALA15
D	HOH103

---

Functional Information from PROSITE/UniProt

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
C	ALY14-LEU20

---

site_id	PS01359
Number of Residues	81
Details	ZF_PHD_1 Zinc finger PHD-type signature. CadCgnsghpsclkfspeltvrvkalrwqciecktcsscrdqgknadnmLfCds..Cdrg.FHmeCcdppltrmpkgm.................................WiCqiC

Chain	Residue	Details
A	CYS230-CYS310

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	118
Details	Zinc finger: {"description":"PHD-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Citrulline; alternate","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by HASPIN and VRK1","evidences":[{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31527692","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"5-glutamyl serotonin; alternate","evidences":[{"source":"PubMed","id":"30867594","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"PubMed","id":"20228790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Symmetric dimethylarginine; by PRMT5; alternate","evidences":[{"source":"UniProtKB","id":"P68433","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"11242053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5","evidences":[{"source":"PubMed","id":"10464286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11856369","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12560483","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKC and CHEK1","evidences":[{"source":"PubMed","id":"12560483","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18066052","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18243098","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22901803","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---