4LJZ
Crystal Structure Analysis of the E.coli holoenzyme
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0046983 | molecular_function | protein dimerization activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0046983 | molecular_function | protein dimerization activity |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0032549 | molecular_function | ribonucleoside binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| D | 0006351 | biological_process | DNA-templated transcription |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| E | 0006351 | biological_process | DNA-templated transcription |
| F | 0003677 | molecular_function | DNA binding |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0006352 | biological_process | DNA-templated transcription initiation |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0016987 | molecular_function | sigma factor activity |
| G | 0003677 | molecular_function | DNA binding |
| G | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| G | 0006351 | biological_process | DNA-templated transcription |
| G | 0046983 | molecular_function | protein dimerization activity |
| H | 0003677 | molecular_function | DNA binding |
| H | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| H | 0006351 | biological_process | DNA-templated transcription |
| H | 0046983 | molecular_function | protein dimerization activity |
| I | 0003677 | molecular_function | DNA binding |
| I | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| I | 0006351 | biological_process | DNA-templated transcription |
| I | 0032549 | molecular_function | ribonucleoside binding |
| J | 0003677 | molecular_function | DNA binding |
| J | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| J | 0006351 | biological_process | DNA-templated transcription |
| K | 0003677 | molecular_function | DNA binding |
| K | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| K | 0006351 | biological_process | DNA-templated transcription |
| L | 0003677 | molecular_function | DNA binding |
| L | 0003700 | molecular_function | DNA-binding transcription factor activity |
| L | 0006352 | biological_process | DNA-templated transcription initiation |
| L | 0006355 | biological_process | regulation of DNA-templated transcription |
| L | 0016987 | molecular_function | sigma factor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG D 1501 |
| Chain | Residue |
| D | ASP460 |
| D | ASP462 |
| D | ASP464 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1502 |
| Chain | Residue |
| D | CYS70 |
| D | CYS72 |
| D | CYS85 |
| D | CYS88 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1503 |
| Chain | Residue |
| D | CYS895 |
| D | CYS898 |
| D | CYS814 |
| D | CYS888 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG J 1501 |
| Chain | Residue |
| J | ASP460 |
| J | ASP462 |
| J | ASP464 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN J 1502 |
| Chain | Residue |
| J | CYS70 |
| J | CYS72 |
| J | CYS85 |
| J | CYS88 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN J 1503 |
| Chain | Residue |
| J | CYS814 |
| J | CYS888 |
| J | CYS895 |
| J | CYS898 |
Functional Information from PROSITE/UniProt
| site_id | PS00715 |
| Number of Residues | 14 |
| Details | SIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnIGLMkAV |
| Chain | Residue | Details |
| F | ASP403-VAL416 |
| site_id | PS00716 |
| Number of Residues | 27 |
| Details | SIGMA70_2 Sigma-70 factors family signature 2. TleEVGkqfdVTrerIrQIEakaLrkL |
| Chain | Residue | Details |
| F | THR572-LEU598 |
| site_id | PS01166 |
| Number of Residues | 13 |
| Details | RNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGV |
| Chain | Residue | Details |
| C | GLY1063-VAL1075 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 38 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 140 |
| Details | Region: {"description":"Sigma-70 factor domain-2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 152 |
| Details | Region: {"description":"Sigma-70 factor domain-3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 106 |
| Details | Region: {"description":"Sigma-70 factor domain-4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 30 |
| Details | Region: {"description":"Interaction with anti-sigma factors"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Motif: {"description":"Interaction with polymerase core subunit RpoC"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with anti-sigma factors"} |
| Chain | Residue | Details |
