4LIS

Crystal Structure of UDP-galactose-4-epimerase from Aspergillus nidulans

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003978	molecular_function	UDP-glucose 4-epimerase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006012	biological_process	galactose metabolic process
A	0016853	molecular_function	isomerase activity
A	0033499	biological_process	galactose catabolic process via UDP-galactose
B	0000166	molecular_function	nucleotide binding
B	0003978	molecular_function	UDP-glucose 4-epimerase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006012	biological_process	galactose metabolic process
B	0016853	molecular_function	isomerase activity
B	0033499	biological_process	galactose catabolic process via UDP-galactose
C	0000166	molecular_function	nucleotide binding
C	0003978	molecular_function	UDP-glucose 4-epimerase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006012	biological_process	galactose metabolic process
C	0016853	molecular_function	isomerase activity
C	0033499	biological_process	galactose catabolic process via UDP-galactose

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE UPG A 401

Chain	Residue
A	LYS88
A	LEU235
A	LEU236
A	VAL237
A	PHE238
A	ALA249
A	ARG251
A	TYR253
A	ARG313
A	ASP316
A	NAD402
A	SER128
A	ALA129
A	TYR156
A	PHE198
A	ASN199
A	ASN219
A	LEU220
A	LEU223

---

site_id	AC2
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAD A 402

Chain	Residue
A	THR12
A	GLY13
A	TYR14
A	ILE15
A	ASP34
A	ASN35
A	TYR37
A	ASN38
A	SER39
A	LEU60
A	ASP61
A	VAL62
A	PHE84
A	ALA85
A	ALA86
A	LYS88
A	SER128
A	TYR156
A	LYS160
A	TYR197
A	PHE198
A	PRO200
A	UPG401

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 403

Chain	Residue
A	GLU146
A	HIS147
A	ALA279
A	ARG326

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 405

Chain	Residue
A	ARG312

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 406

Chain	Residue
A	PRO97
A	GLN174

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE UDP B 401

Chain	Residue
B	ASN199
B	ASN219
B	LEU220
B	LEU223
B	LEU236
B	VAL237
B	PHE238
B	ALA249
B	ARG251
B	VAL290
B	ARG313
B	ASP316

---

site_id	AC7
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD B 402

Chain	Residue
B	THR12
B	GLY13
B	TYR14
B	ILE15
B	ASP34
B	ASN35
B	TYR37
B	ASN38
B	SER39
B	LEU60
B	ASP61
B	VAL62
B	PHE84
B	ALA85
B	ALA86
B	LYS88
B	SER126
B	SER127
B	SER128
B	TYR156
B	LYS160
B	TYR197
B	PHE198
B	PRO200
B	HOH518
B	HOH522

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD B 404

Chain	Residue
B	ALA243
B	ARG312

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD B 405

Chain	Residue
B	GLN174
C	LEU98

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE UDP C 401

Chain	Residue
C	PHE238
C	ARG251
C	VAL290
C	ARG313
C	ASP316
C	HOH502
C	ASN199
C	TYR218
C	ASN219
C	LEU220
C	LEU223
C	LEU235
C	LEU236
C	VAL237

---

site_id	BC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD C 402

Chain	Residue
C	THR12
C	GLY13
C	TYR14
C	ILE15
C	ASP34
C	ASN35
C	TYR37
C	ASN38
C	SER39
C	LEU60
C	ASP61
C	VAL62
C	PHE84
C	ALA85
C	ALA86
C	LYS88
C	SER126
C	SER127
C	SER128
C	TYR156
C	LYS160
C	TYR197
C	PRO200
C	HOH511
C	HOH515

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD C 404

Chain	Residue
C	ALA243
C	ARG312

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD C 405

Chain	Residue
B	PRO97
C	GLN174

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