4LIP

PSEUDOMONAS LIPASE COMPLEXED WITH RC-(RP, SP)-DIBUTYLCARBAMOYLGLYCERO-3-O-BUTYLPHOSPHONATE

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0004806	molecular_function	triacylglycerol lipase activity
D	0005576	cellular_component	extracellular region
D	0006629	biological_process	lipid metabolic process
D	0016042	biological_process	lipid catabolic process
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
E	0004806	molecular_function	triacylglycerol lipase activity
E	0005576	cellular_component	extracellular region
E	0006629	biological_process	lipid metabolic process
E	0016042	biological_process	lipid catabolic process
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA D 321

Chain	Residue
D	ASP242
D	ASP288
D	GLN292
D	LEU293
D	VAL296
D	HOH975
D	HOH988

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA E 321

Chain	Residue
E	ASP242
E	ASP288
E	GLN292
E	LEU293
E	VAL296
E	HOH985
E	HOH998

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CCP D 950

Chain	Residue
D	GLY16
D	LEU17
D	SER87
D	GLN88
D	SER117
D	VAL267
D	HIS286

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CCP E 950

Chain	Residue
E	GLY16
E	LEU17
E	SER87
E	GLN88
E	SER117
E	LEU167
E	VAL267
E	HIS286

---

site_id	ACD
Number of Residues	3
Details	ACTIVE SITE

Chain	Residue
D	SER87
D	HIS286
D	ASP264

---

site_id	ACE
Number of Residues	3
Details	ACTIVE SITE

Chain	Residue
E	SER87
E	HIS286
E	ASP264

---

site_id	OXD
Number of Residues	2
Details	OXYANION HOLE

Chain	Residue
D	LEU17
D	GLN88

---

site_id	OXE
Number of Residues	2
Details	OXYANION HOLE

Chain	Residue
E	GLN88
E	LEU17

---

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VNLVGHSQGG

Chain	Residue	Details
D	VAL81-GLY90

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	424
Details	Domain: {"description":"AB hydrolase-1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"11453990","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15850979","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18386861","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9032073","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9032074","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9660188","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1HQD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11453990","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9032073","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9032074","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9660188","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11453990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15850979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18386861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9660188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HQD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LIP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11453990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15850979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18386861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9032073","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9032074","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9660188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HQD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OIL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1tah

Chain	Residue	Details
D	ASP264
D	HIS286
D	SER87

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1tah

Chain	Residue	Details
E	ASP264
E	HIS286
E	SER87

---

site_id	CSA3
Number of Residues	5
Details	Annotated By Reference To The Literature 1tah

Chain	Residue	Details
D	ASP264
D	HIS286
D	LEU17
D	GLN88
D	SER87

---

site_id	CSA4
Number of Residues	5
Details	Annotated By Reference To The Literature 1tah

Chain	Residue	Details
E	ASP264
E	HIS286
E	LEU17
E	GLN88
E	SER87

---