4LIP

PSEUDOMONAS LIPASE COMPLEXED WITH RC-(RP, SP)-DIBUTYLCARBAMOYLGLYCERO-3-O-BUTYLPHOSPHONATE

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0004806	molecular_function	triglyceride lipase activity
D	0005576	cellular_component	extracellular region
D	0016042	biological_process	lipid catabolic process
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
E	0004806	molecular_function	triglyceride lipase activity
E	0005576	cellular_component	extracellular region
E	0016042	biological_process	lipid catabolic process
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA D 321

Chain	Residue
D	ASP242
D	ASP288
D	GLN292
D	LEU293
D	VAL296
D	HOH975
D	HOH988

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA E 321

Chain	Residue
E	ASP242
E	ASP288
E	GLN292
E	LEU293
E	VAL296
E	HOH985
E	HOH998

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CCP D 950

Chain	Residue
D	GLY16
D	LEU17
D	SER87
D	GLN88
D	SER117
D	VAL267
D	HIS286

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CCP E 950

Chain	Residue
E	GLY16
E	LEU17
E	SER87
E	GLN88
E	SER117
E	LEU167
E	VAL267
E	HIS286

---

site_id	ACD
Number of Residues	3
Details	ACTIVE SITE

Chain	Residue
D	SER87
D	HIS286
D	ASP264

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site_id	ACE
Number of Residues	3
Details	ACTIVE SITE

Chain	Residue
E	SER87
E	HIS286
E	ASP264

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site_id	OXD
Number of Residues	2
Details	OXYANION HOLE

Chain	Residue
D	LEU17
D	GLN88

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site_id	OXE
Number of Residues	2
Details	OXYANION HOLE

Chain	Residue
E	GLN88
E	LEU17

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Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VNLVGHSQGG

Chain	Residue	Details
D	VAL81-GLY90

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:11453990, ECO:0000305|PubMed:15850979, ECO:0000305|PubMed:18386861, ECO:0000305|PubMed:9032073, ECO:0000305|PubMed:9032074, ECO:0000305|PubMed:9660188, ECO:0007744|PDB:1HQD, ECO:0007744|PDB:1YS1, ECO:0007744|PDB:1YS2, ECO:0007744|PDB:2NW6, ECO:0007744|PDB:4LIP, ECO:0007744|PDB:5LIP

Chain	Residue	Details
D	SER87
E	SER87

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:11453990, ECO:0000305|PubMed:9032073, ECO:0000305|PubMed:9032074, ECO:0000305|PubMed:9660188, ECO:0007744|PDB:4LIP, ECO:0007744|PDB:5LIP

Chain	Residue	Details
D	ASP264
D	HIS286
E	ASP264
E	HIS286

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:11453990, ECO:0000269|PubMed:15850979, ECO:0000269|PubMed:18386861, ECO:0000269|PubMed:9660188, ECO:0007744|PDB:1HQD, ECO:0007744|PDB:1YS1, ECO:0007744|PDB:1YS2, ECO:0007744|PDB:2NW6, ECO:0007744|PDB:4LIP

Chain	Residue	Details
D	LEU17
D	GLN88
E	LEU17
E	GLN88

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:11453990, ECO:0000269|PubMed:15850979, ECO:0000269|PubMed:18386861, ECO:0000269|PubMed:9032073, ECO:0000269|PubMed:9032074, ECO:0000269|PubMed:9660188, ECO:0007744|PDB:1HQD, ECO:0007744|PDB:1OIL, ECO:0007744|PDB:1YS1, ECO:0007744|PDB:1YS2, ECO:0007744|PDB:2LIP, ECO:0007744|PDB:2NW6, ECO:0007744|PDB:3LIP, ECO:0007744|PDB:4LIP, ECO:0007744|PDB:5LIP

Chain	Residue	Details
D	ASP242
D	ASP288
D	GLN292
D	VAL296
E	ASP242
E	ASP288
E	GLN292
E	VAL296

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1tah

Chain	Residue	Details
D	ASP264
D	HIS286
D	SER87

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1tah

Chain	Residue	Details
E	ASP264
E	HIS286
E	SER87

---

site_id	CSA3
Number of Residues	5
Details	Annotated By Reference To The Literature 1tah

Chain	Residue	Details
D	ASP264
D	HIS286
D	LEU17
D	GLN88
D	SER87

---

site_id	CSA4
Number of Residues	5
Details	Annotated By Reference To The Literature 1tah

Chain	Residue	Details
E	ASP264
E	HIS286
E	LEU17
E	GLN88
E	SER87

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