4LHV
Crystal structure of Rab8 in its inactive GDP-bound form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005525 | molecular_function | GTP binding |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005525 | molecular_function | GTP binding |
| E | 0003924 | molecular_function | GTPase activity |
| E | 0005525 | molecular_function | GTP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GDP A 201 |
| Chain | Residue |
| A | GLY18 |
| A | LYS122 |
| A | ASP124 |
| A | VAL125 |
| A | SER151 |
| A | ALA152 |
| A | LYS153 |
| A | MG202 |
| A | HOH321 |
| A | HOH349 |
| A | HOH351 |
| A | VAL19 |
| A | HOH356 |
| A | HOH380 |
| B | GLU51 |
| B | GLY54 |
| B | LYS55 |
| B | ARG56 |
| A | GLY20 |
| A | LYS21 |
| A | THR22 |
| A | CYS23 |
| A | PHE33 |
| A | ASN34 |
| A | ASN121 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 202 |
| Chain | Residue |
| A | THR22 |
| A | GDP201 |
| A | HOH321 |
| A | HOH351 |
| A | HOH379 |
| A | HOH380 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDP B 201 |
| Chain | Residue |
| B | SER17 |
| B | GLY18 |
| B | VAL19 |
| B | GLY20 |
| B | LYS21 |
| B | THR22 |
| B | CYS23 |
| B | PHE33 |
| B | ASN121 |
| B | LYS122 |
| B | ASP124 |
| B | VAL125 |
| B | SER151 |
| B | ALA152 |
| B | LYS153 |
| B | MG202 |
| B | HOH306 |
| B | HOH312 |
| B | HOH330 |
| B | HOH342 |
| B | HOH386 |
| E | GLY54 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 202 |
| Chain | Residue |
| B | THR22 |
| B | GDP201 |
| B | HOH330 |
| B | HOH342 |
| B | HOH372 |
| B | HOH386 |
| site_id | AC5 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE GDP C 201 |
| Chain | Residue |
| C | ASP16 |
| C | SER17 |
| C | GLY18 |
| C | VAL19 |
| C | GLY20 |
| C | LYS21 |
| C | THR22 |
| C | CYS23 |
| C | PHE33 |
| C | ASN34 |
| C | ASN121 |
| C | LYS122 |
| C | ASP124 |
| C | VAL125 |
| C | SER151 |
| C | ALA152 |
| C | LYS153 |
| C | MG202 |
| C | HOH329 |
| C | HOH330 |
| C | HOH356 |
| C | HOH366 |
| C | HOH367 |
| D | GLU51 |
| D | GLY54 |
| D | ARG56 |
| D | HOH334 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 202 |
| Chain | Residue |
| C | THR22 |
| C | GDP201 |
| C | HOH329 |
| C | HOH330 |
| C | HOH354 |
| C | HOH366 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDP D 201 |
| Chain | Residue |
| D | PHE33 |
| D | PHE37 |
| D | ASN121 |
| D | LYS122 |
| D | ASP124 |
| D | VAL125 |
| D | SER151 |
| D | ALA152 |
| D | LYS153 |
| D | MG202 |
| D | HOH304 |
| D | HOH316 |
| D | HOH321 |
| D | HOH347 |
| D | HOH369 |
| D | SER17 |
| D | GLY18 |
| D | VAL19 |
| D | GLY20 |
| D | LYS21 |
| D | THR22 |
| D | CYS23 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG D 202 |
| Chain | Residue |
| D | THR22 |
| D | ASP63 |
| D | GDP201 |
| D | HOH304 |
| D | HOH321 |
| D | HOH325 |
| D | HOH369 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GDP E 201 |
| Chain | Residue |
| E | ASP16 |
| E | SER17 |
| E | GLY18 |
| E | VAL19 |
| E | GLY20 |
| E | LYS21 |
| E | THR22 |
| E | CYS23 |
| E | ASN121 |
| E | LYS122 |
| E | ASP124 |
| E | SER151 |
| E | ALA152 |
| E | LYS153 |
| E | MG202 |
| E | HOH301 |
| E | HOH314 |
| E | HOH319 |
| E | HOH320 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG E 202 |
| Chain | Residue |
| E | THR22 |
| E | GDP201 |
| E | HOH301 |
| E | HOH314 |
| E | HOH320 |
Functional Information from PROSITE/UniProt
| site_id | PS00675 |
| Number of Residues | 14 |
| Details | SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. LLLiGDSGVGKtcV |
| Chain | Residue | Details |
| A | LEU11-VAL24 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Motif: {"description":"Switch 1","evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 45 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21378754","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5SZI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21378754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21378754","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QBT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21378754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QBT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
