4LG1

Human Methyltransferase-Like Protein 21D

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006479	biological_process	protein methylation
A	0008168	molecular_function	methyltransferase activity
A	0008276	molecular_function	protein methyltransferase activity
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0018022	biological_process	peptidyl-lysine methylation
A	0018023	biological_process	peptidyl-lysine trimethylation
A	0032259	biological_process	methylation
A	0032780	biological_process	negative regulation of ATP-dependent activity
A	0032991	cellular_component	protein-containing complex
A	0051117	molecular_function	ATPase binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006479	biological_process	protein methylation
B	0008168	molecular_function	methyltransferase activity
B	0008276	molecular_function	protein methyltransferase activity
B	0016279	molecular_function	protein-lysine N-methyltransferase activity
B	0016740	molecular_function	transferase activity
B	0018022	biological_process	peptidyl-lysine methylation
B	0018023	biological_process	peptidyl-lysine trimethylation
B	0032259	biological_process	methylation
B	0032780	biological_process	negative regulation of ATP-dependent activity
B	0032991	cellular_component	protein-containing complex
B	0051117	molecular_function	ATPase binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006479	biological_process	protein methylation
C	0008168	molecular_function	methyltransferase activity
C	0008276	molecular_function	protein methyltransferase activity
C	0016279	molecular_function	protein-lysine N-methyltransferase activity
C	0016740	molecular_function	transferase activity
C	0018022	biological_process	peptidyl-lysine methylation
C	0018023	biological_process	peptidyl-lysine trimethylation
C	0032259	biological_process	methylation
C	0032780	biological_process	negative regulation of ATP-dependent activity
C	0032991	cellular_component	protein-containing complex
C	0051117	molecular_function	ATPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SAM A 301

Chain	Residue
A	VAL41
A	LYS125
A	TRP126
A	ALA143
A	ASP144
A	TYR147
A	TYR148
A	HOH416
A	HOH417
A	HOH452
A	TRP43
A	ALA46
A	GLY75
A	SER76
A	GLY77
A	ASP96
A	LEU97
A	LEU124

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 302

Chain	Residue
A	LYS200
A	LEU203
A	GLU213
A	ILE215
A	HIS216
A	HOH404

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SAM B 301

Chain	Residue
B	VAL41
B	TRP43
B	ALA46
B	GLY75
B	SER76
B	GLY77
B	ASP96
B	LEU97
B	LEU124
B	LYS125
B	TRP126
B	ALA143
B	ASP144
B	TYR147
B	TYR148
B	HOH403
B	HOH422
B	HOH468

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 302

Chain	Residue
B	SER59
B	HIS64
B	HOH419
B	HOH445
B	HOH457

---

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SAM C 301

Chain	Residue
C	VAL41
C	TRP43
C	ALA46
C	GLY75
C	SER76
C	GLY77
C	ASP96
C	LEU97
C	LEU124
C	LYS125
C	TRP126
C	ALA143
C	ASP144
C	TYR147
C	TYR148
C	HOH407
C	HOH409
C	HOH429

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2013","submissionDatabase":"PDB data bank","title":"The crystal structure of human methyltransferase-like protein 21D in complex with SAM.","authors":["Zeng H.","Dong A.","Fenner M.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Brown P.J.","Wu H."]}}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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