4LG1
Human Methyltransferase-Like Protein 21D
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006479 | biological_process | protein methylation |
| A | 0008276 | molecular_function | protein methyltransferase activity |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0018023 | biological_process | peptidyl-lysine trimethylation |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0036503 | biological_process | ERAD pathway |
| A | 0051117 | molecular_function | ATPase binding |
| A | 0140535 | cellular_component | intracellular protein-containing complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006479 | biological_process | protein methylation |
| B | 0008276 | molecular_function | protein methyltransferase activity |
| B | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| B | 0018023 | biological_process | peptidyl-lysine trimethylation |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0036503 | biological_process | ERAD pathway |
| B | 0051117 | molecular_function | ATPase binding |
| B | 0140535 | cellular_component | intracellular protein-containing complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006479 | biological_process | protein methylation |
| C | 0008276 | molecular_function | protein methyltransferase activity |
| C | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| C | 0018023 | biological_process | peptidyl-lysine trimethylation |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0036503 | biological_process | ERAD pathway |
| C | 0051117 | molecular_function | ATPase binding |
| C | 0140535 | cellular_component | intracellular protein-containing complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SAM A 301 |
| Chain | Residue |
| A | VAL41 |
| A | LYS125 |
| A | TRP126 |
| A | ALA143 |
| A | ASP144 |
| A | TYR147 |
| A | TYR148 |
| A | HOH416 |
| A | HOH417 |
| A | HOH452 |
| A | TRP43 |
| A | ALA46 |
| A | GLY75 |
| A | SER76 |
| A | GLY77 |
| A | ASP96 |
| A | LEU97 |
| A | LEU124 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 302 |
| Chain | Residue |
| A | LYS200 |
| A | LEU203 |
| A | GLU213 |
| A | ILE215 |
| A | HIS216 |
| A | HOH404 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SAM B 301 |
| Chain | Residue |
| B | VAL41 |
| B | TRP43 |
| B | ALA46 |
| B | GLY75 |
| B | SER76 |
| B | GLY77 |
| B | ASP96 |
| B | LEU97 |
| B | LEU124 |
| B | LYS125 |
| B | TRP126 |
| B | ALA143 |
| B | ASP144 |
| B | TYR147 |
| B | TYR148 |
| B | HOH403 |
| B | HOH422 |
| B | HOH468 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 302 |
| Chain | Residue |
| B | SER59 |
| B | HIS64 |
| B | HOH419 |
| B | HOH445 |
| B | HOH457 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SAM C 301 |
| Chain | Residue |
| C | VAL41 |
| C | TRP43 |
| C | ALA46 |
| C | GLY75 |
| C | SER76 |
| C | GLY77 |
| C | ASP96 |
| C | LEU97 |
| C | LEU124 |
| C | LYS125 |
| C | TRP126 |
| C | ALA143 |
| C | ASP144 |
| C | TYR147 |
| C | TYR148 |
| C | HOH407 |
| C | HOH409 |
| C | HOH429 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 21 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2013","submissionDatabase":"PDB data bank","title":"The crystal structure of human methyltransferase-like protein 21D in complex with SAM.","authors":["Zeng H.","Dong A.","Fenner M.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Brown P.J.","Wu H."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
