4LFQ
High resolution x-ray crystal structure of L-ShK toxin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0015459 | molecular_function | potassium channel regulator activity |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042151 | cellular_component | nematocyst |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0090729 | molecular_function | toxin activity |
| A | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 34 |
| Details | Peptide: {"description":"Kappa-stichotoxin-She3a","featureId":"PRO_0000044866","evidences":[{"source":"PubMed","id":"7660365","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"book","publicationDate":"1992","firstPage":"35","lastPage":"35","publisher":"Paris","bookName":"Xeme congres europeen de toxinologie","authors":["Karlsson E.","Harvey A.L.","Aneiros A.","Castaneda O."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Domain: {"description":"ShKT","evidences":[{"source":"PROSITE-ProRule","id":"PRU01005","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Key residue for binding both Kv1.2/KCNA2 and Kv1.3/KCNA3 (occludes the channel pore like a cork in a bottle)","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
