4LFG
Crystal structure of geranylgeranyl diphosphate synthase sub1274 (target efi-509455) from streptococcus uberis 0140j with bound magnesium and isopentyl diphosphate, fully liganded complex;
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016114 | biological_process | terpenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE IPE A 301 |
| Chain | Residue |
| A | ASP78 |
| A | IPE302 |
| A | MG303 |
| A | MG304 |
| A | MG305 |
| A | HOH415 |
| A | HOH422 |
| A | HOH431 |
| A | HOH490 |
| A | HOH507 |
| A | HOH577 |
| A | ASP84 |
| A | HOH578 |
| A | HOH580 |
| A | HOH639 |
| A | ARG89 |
| A | GLN149 |
| A | LYS172 |
| A | THR173 |
| A | ASP213 |
| A | ASP217 |
| A | LYS227 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE IPE A 302 |
| Chain | Residue |
| A | GLY37 |
| A | LYS38 |
| A | ARG41 |
| A | HIS71 |
| A | LEU75 |
| A | ARG90 |
| A | THR173 |
| A | PHE209 |
| A | GLN210 |
| A | ASP213 |
| A | IPE301 |
| A | HOH404 |
| A | HOH406 |
| A | HOH409 |
| A | HOH410 |
| A | HOH412 |
| A | HOH579 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 303 |
| Chain | Residue |
| A | ASP78 |
| A | ASP84 |
| A | IPE301 |
| A | MG304 |
| A | HOH431 |
| A | HOH490 |
| A | HOH495 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 304 |
| Chain | Residue |
| A | ASP78 |
| A | ASP84 |
| A | IPE301 |
| A | MG303 |
| A | HOH415 |
| A | HOH422 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 305 |
| Chain | Residue |
| A | ASP213 |
| A | ASP217 |
| A | IPE301 |
| A | HOH507 |
| A | HOH577 |
| A | HOH578 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE IPE B 301 |
| Chain | Residue |
| B | ASP78 |
| B | ASP84 |
| B | ARG89 |
| B | LYS172 |
| B | THR173 |
| B | GLN210 |
| B | ASP213 |
| B | LYS227 |
| B | IPE302 |
| B | MG303 |
| B | MG304 |
| B | MG305 |
| B | HOH406 |
| B | HOH408 |
| B | HOH411 |
| B | HOH444 |
| B | HOH446 |
| B | HOH447 |
| B | HOH557 |
| B | HOH604 |
| B | HOH605 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE IPE B 302 |
| Chain | Residue |
| B | GLY37 |
| B | LYS38 |
| B | ARG41 |
| B | HIS71 |
| B | LEU75 |
| B | ARG90 |
| B | THR173 |
| B | PHE209 |
| B | GLN210 |
| B | ASP213 |
| B | IPE301 |
| B | HOH404 |
| B | HOH405 |
| B | HOH409 |
| B | HOH416 |
| B | HOH419 |
| B | HOH497 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 303 |
| Chain | Residue |
| B | HOH604 |
| B | HOH605 |
| B | ASP213 |
| B | IPE301 |
| B | HOH406 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 304 |
| Chain | Residue |
| B | ASP78 |
| B | ASP84 |
| B | IPE301 |
| B | MG305 |
| B | HOH444 |
| B | HOH493 |
| B | HOH557 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 305 |
| Chain | Residue |
| B | ASP78 |
| B | ASP84 |
| B | IPE301 |
| B | MG304 |
| B | HOH408 |
| B | HOH411 |
Functional Information from PROSITE/UniProt
