4LCL
Simvastatin Synthase (LOVD), from Aspergillus Terreus, LovD6 mutant (simh6208)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016218 | molecular_function | polyketide synthase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0030639 | biological_process | polyketide biosynthetic process |
| A | 0050832 | biological_process | defense response to fungus |
| A | 0140735 | biological_process | lovastatin biosynthetic process |
| B | 0016218 | molecular_function | polyketide synthase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017000 | biological_process | antibiotic biosynthetic process |
| B | 0030639 | biological_process | polyketide biosynthetic process |
| B | 0050832 | biological_process | defense response to fungus |
| B | 0140735 | biological_process | lovastatin biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IPA A 501 |
| Chain | Residue |
| A | SER76 |
| A | TYR188 |
| A | GLY364 |
| A | TRP390 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IPA B 501 |
| Chain | Residue |
| B | SER76 |
| B | TYR188 |
| B | TRP390 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Acyl-ester intermediate => ECO:0000269|PubMed:17113998, ECO:0000269|PubMed:19875080 |
| Chain | Residue | Details |
| A | SER76 | |
| B | SER76 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG73 | |
| B | TYR188 | |
| B | TYR258 | |
| B | GLY366 | |
| B | GLU388 | |
| B | TRP390 | |
| A | ARG173 | |
| A | TYR188 | |
| A | TYR258 | |
| A | GLY366 | |
| A | GLU388 | |
| A | TRP390 | |
| B | ARG73 | |
| B | ARG173 |
