4LC0

Identifying ligand binding hot spots in proteins using brominated fragments

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE GNP A 501

Chain	Residue
A	VAL20
A	THR62
A	GLY84
A	ASN136
A	LYS137
A	ASP139
A	MET140
A	SER174
A	ALA175
A	LEU176
A	GLN354
A	ASP21
A	MG502
A	HOH606
A	HOH635
A	HOH720
A	HOH721
A	HOH782
A	HOH783
A	HIS22
A	GLY23
A	LYS24
A	THR25
A	THR26
A	TYR47
A	ILE61

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 502

Chain	Residue
A	THR25
A	THR62
A	GNP501
A	HOH720
A	HOH721

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NH4 A 503

Chain	Residue
A	ILE50
A	ASP51
A	GLU56
A	THR62
A	ASN64
A	HOH602

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 504

Chain	Residue
A	MET113
A	PRO114
A	ARG117
A	HOH737
A	HOH784

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 505

Chain	Residue
A	LYS45
A	HIS67
A	HIS273
A	ARG274

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 506

Chain	Residue
A	ARG59
A	HIS85

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 507

Chain	Residue
A	LYS248
A	ARG291
A	HOH710

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 508

Chain	Residue
A	ARG330
A	HIS331
A	THR332
A	ARG393
A	HOH763

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 509

Chain	Residue
A	ARG57
A	GLY358
A	HOH634

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 510

Chain	Residue
A	GLN181
A	ARG184

---

Functional Information from PROSITE/UniProt

site_id	PS00301
Number of Residues	16
Details	G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DKapeERaRGITIntA

Chain	Residue	Details
A	ASP51-ALA66

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	205
Details	Domain: {"description":"tr-type G"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Region: {"description":"G1","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"G2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Region: {"description":"G3","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Region: {"description":"G4","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Region: {"description":"G5","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	14
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00118","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---