4LBF

Crystal structure of HUMAN ALPHA-DEFENSIN 1 (HNP1) I20A/L25A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0006952	biological_process	defense response
B	0005576	cellular_component	extracellular region
B	0006952	biological_process	defense response
C	0005576	cellular_component	extracellular region
C	0006952	biological_process	defense response
D	0005576	cellular_component	extracellular region
D	0006952	biological_process	defense response
E	0005576	cellular_component	extracellular region
E	0006952	biological_process	defense response
F	0005576	cellular_component	extracellular region
F	0006952	biological_process	defense response
G	0005576	cellular_component	extracellular region
G	0006952	biological_process	defense response
H	0005576	cellular_component	extracellular region
H	0006952	biological_process	defense response

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL D 101

Chain	Residue
A	GLY23
D	HOH221
D	HOH223
A	ARG24
A	ALA25
A	HOH108
A	HOH130
D	ARG5
D	PRO7
D	HOH205
D	HOH207

---

Functional Information from PROSITE/UniProt

site_id	PS00269
Number of Residues	29
Details	DEFENSIN Mammalian defensins signature. CyCripa.CiagerryGtCayqgrawafCC

Chain	Residue	Details
A	CYS2-CYS30

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	MOD_RES: ADP-ribosylarginine; by ART1 => ECO:0000269|PubMed:21904558

Chain	Residue	Details
A	ARG14
A	ARG24
B	ARG14
B	ARG24
C	ARG14
C	ARG24
D	ARG14
D	ARG24
E	ARG14
E	ARG24
F	ARG14
F	ARG24
G	ARG14
G	ARG24
H	ARG14
H	ARG24

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21904558

Chain	Residue	Details
A	TYR21
B	TYR21
C	TYR21
D	TYR21
E	TYR21
F	TYR21
G	TYR21
H	TYR21

---