4LBF

Crystal structure of HUMAN ALPHA-DEFENSIN 1 (HNP1) I20A/L25A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0006952	biological_process	defense response
B	0005576	cellular_component	extracellular region
B	0006952	biological_process	defense response
C	0005576	cellular_component	extracellular region
C	0006952	biological_process	defense response
D	0005576	cellular_component	extracellular region
D	0006952	biological_process	defense response
E	0005576	cellular_component	extracellular region
E	0006952	biological_process	defense response
F	0005576	cellular_component	extracellular region
F	0006952	biological_process	defense response
G	0005576	cellular_component	extracellular region
G	0006952	biological_process	defense response
H	0005576	cellular_component	extracellular region
H	0006952	biological_process	defense response

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL D 101

Chain	Residue
A	GLY23
D	HOH221
D	HOH223
A	ARG24
A	ALA25
A	HOH108
A	HOH130
D	ARG5
D	PRO7
D	HOH205
D	HOH207

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Functional Information from PROSITE/UniProt

site_id	PS00269
Number of Residues	29
Details	DEFENSIN Mammalian defensins signature. CyCripa.CiagerryGtCayqgrawafCC

Chain	Residue	Details
A	CYS2-CYS30

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	203
Details	Peptide: {"description":"Neutrophil defensin 1","featureId":"PRO_0000006773"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	196
Details	Peptide: {"description":"Neutrophil defensin 2","featureId":"PRO_0000006774"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	15
Details	Modified residue: {"description":"ADP-ribosylarginine; by ART1","evidences":[{"source":"PubMed","id":"21904558","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	7
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21904558","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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