4LA1

Crystal structure of SjTGR (thioredoxin glutathione reductase from Schistosoma japonicumi)complex with FAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
A	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006749	biological_process	glutathione metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
A	0034599	biological_process	cellular response to oxidative stress
A	0045454	biological_process	cell redox homeostasis
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0098869	biological_process	cellular oxidant detoxification
B	0000166	molecular_function	nucleotide binding
B	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
B	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006749	biological_process	glutathione metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
B	0034599	biological_process	cellular response to oxidative stress
B	0045454	biological_process	cell redox homeostasis
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	40
Details	BINDING SITE FOR RESIDUE FAD A 600

Chain	Residue
A	ILE113
A	THR153
A	CYS154
A	VAL157
A	GLY158
A	CYS159
A	LYS162
A	ALA226
A	ARG227
A	GLY228
A	ALA256
A	GLY114
A	THR257
A	GLY258
A	TYR296
A	VAL297
A	ARG393
A	LEU400
A	GLY432
A	ASP433
A	GLN440
A	LEU441
A	GLY115
A	THR442
A	PRO443
A	HOH721
A	HOH730
A	HOH750
A	HOH787
A	HOH897
A	HOH926
B	HIS571
B	PRO572
A	GLY116
B	HOH711
A	SER117
A	GLY118
A	ASP137
A	TYR138
A	GLY152

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site_id	AC2
Number of Residues	41
Details	BINDING SITE FOR RESIDUE FAD B 600

Chain	Residue
A	HIS571
A	PRO572
A	HOH722
B	GLY114
B	GLY115
B	GLY116
B	SER117
B	GLY118
B	LEU136
B	ASP137
B	TYR138
B	GLY152
B	THR153
B	CYS154
B	VAL157
B	GLY158
B	CYS159
B	LYS162
B	ALA226
B	ARG227
B	GLY228
B	ALA256
B	THR257
B	GLY258
B	TYR296
B	VAL297
B	LYS300
B	ARG393
B	LEU400
B	GLY432
B	ASP433
B	GLN440
B	LEU441
B	THR442
B	PRO443
B	HOH708
B	HOH718
B	HOH720
B	HOH810
B	HOH828
B	HOH896

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Functional Information from PROSITE/UniProt

site_id	PS00076
Number of Residues	11
Details	PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP

Chain	Residue	Details
A	GLY151-PRO161

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