4L87

Crystal structure of the human seryl-tRNA synthetase in complex with Ser-SA at 2.9 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000166	molecular_function	nucleotide binding
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0001514	biological_process	selenocysteine incorporation
A	0002181	biological_process	cytoplasmic translation
A	0003677	molecular_function	DNA binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004828	molecular_function	serine-tRNA ligase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006400	biological_process	tRNA modification
A	0006412	biological_process	translation
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006434	biological_process	seryl-tRNA aminoacylation
A	0016525	biological_process	negative regulation of angiogenesis
A	0016874	molecular_function	ligase activity
A	0019899	molecular_function	enzyme binding
A	0042803	molecular_function	protein homodimerization activity
A	0060090	molecular_function	molecular adaptor activity
A	0070062	cellular_component	extracellular exosome
A	0098619	molecular_function	selenocysteine-tRNA ligase activity
A	1904046	biological_process	negative regulation of vascular endothelial growth factor production

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SSA A 501

Chain	Residue
A	THR271
A	GLU325
A	GLU391
A	LEU392
A	VAL393
A	SER394
A	ASN427
A	THR429
A	ALA432
A	THR434
A	ARG435
A	GLU273
A	MG504
A	ARG302
A	GLU304
A	PHE316
A	ARG317
A	VAL318
A	PHE321
A	LYS323

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 502

Chain	Residue
A	ARG310
A	PHE316
A	ARG317
A	ARG390
A	GLU391

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 503

Chain	Residue
A	LYS376
A	ASP378
A	GLU391

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 504

Chain	Residue
A	GLU246
A	SSA501

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	52
Details	Region: {"description":"Interaction with tRNA","evidences":[{"source":"PubMed","id":"26433229","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24095058","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4L87","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24095058","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26433229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4L87","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Important for serine binding","evidences":[{"source":"PubMed","id":"28236339","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---