4L7D

Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008134	molecular_function	transcription factor binding
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
B	0008134	molecular_function	transcription factor binding
B	0016567	biological_process	protein ubiquitination
B	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
C	0008134	molecular_function	transcription factor binding
C	0016567	biological_process	protein ubiquitination
C	0031463	cellular_component	Cul3-RING ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1VX A 701

Chain	Residue
A	TYR334
A	ASN414
A	ARG415
A	GLY509
A	ALA556
A	SER602
A	ACT702
A	HOH802
A	HOH879

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 702

Chain	Residue
A	TYR525
A	GLN530
A	SER555
A	1VX701
A	HOH878
A	HOH914

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 703

Chain	Residue
A	LEU471
A	TYR491
A	PRO492
A	GLU493
A	ARG494
A	HOH890

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 1VX B 701

Chain	Residue
B	TYR334
B	ARG380
B	ASN382
B	ASN414
B	ARG415
B	GLY509
B	ALA556
B	TYR572
B	SER602
B	ACT703
B	HOH802
B	HOH823

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 702

Chain	Residue
B	ARG415
B	PHE478
B	ARG483
B	SER508
B	HOH835

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 703

Chain	Residue
B	TYR525
B	GLN530
B	SER555
B	TYR572
B	1VX701

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT B 704

Chain	Residue
B	ASP526
C	ASP479
C	THR481
C	HOH902

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 1VX C 701

Chain	Residue
C	TYR334
C	ASN382
C	ASN414
C	ARG415
C	GLY509
C	ALA556
C	PHE577
C	SER602
C	HOH803

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 702

Chain	Residue
C	ARG415
C	ARG483
C	SER508
C	HOH883
C	HOH909

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 703

Chain	Residue
C	TYR525
C	GLN530
C	SER555
C	TYR572
C	HOH909

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT C 704

Chain	Residue
C	ASN401
C	TYR491
C	PRO492
C	GLU493
C	ARG494
C	HOH901

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 705

Chain	Residue
C	TYR329
C	GLY372
C	PRO398
C	THR609
C	HOH881

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 706

Chain	Residue
A	GLY480
C	CYS434
C	ILE435
C	HIS436
C	ARG459

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	135
Details	Repeat: {"description":"Kelch 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	150
Details	Repeat: {"description":"Kelch 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	138
Details	Repeat: {"description":"Kelch 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	138
Details	Repeat: {"description":"Kelch 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	138
Details	Repeat: {"description":"Kelch 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	92
Details	Repeat: {"description":"Kelch 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---