4L7C
Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008134 | molecular_function | transcription factor binding |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
| B | 0008134 | molecular_function | transcription factor binding |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
| C | 0008134 | molecular_function | transcription factor binding |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 1VW A 701 |
| Chain | Residue |
| A | TYR334 |
| A | HOH803 |
| A | HOH825 |
| A | HOH834 |
| A | ARG380 |
| A | ASN382 |
| A | ASN414 |
| A | ARG415 |
| A | ALA556 |
| A | TYR572 |
| A | SER602 |
| A | ACT702 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 702 |
| Chain | Residue |
| A | TYR525 |
| A | GLN530 |
| A | SER555 |
| A | 1VW701 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1VW B 701 |
| Chain | Residue |
| B | TYR334 |
| B | ARG380 |
| B | ASN382 |
| B | ASN414 |
| B | ARG415 |
| B | ALA556 |
| B | TYR572 |
| B | SER602 |
| B | ACT702 |
| B | HOH801 |
| B | HOH803 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 702 |
| Chain | Residue |
| B | TYR525 |
| B | GLN530 |
| B | SER555 |
| B | 1VW701 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT B 703 |
| Chain | Residue |
| B | PHE478 |
| B | ARG483 |
| B | SER508 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 1VW C 701 |
| Chain | Residue |
| C | TYR334 |
| C | ARG380 |
| C | ASN382 |
| C | ASN414 |
| C | ARG415 |
| C | ALA556 |
| C | TYR572 |
| C | SER602 |
| C | ACT702 |
| C | HOH801 |
| C | HOH834 |
| C | HOH879 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT C 702 |
| Chain | Residue |
| C | TYR525 |
| C | GLN530 |
| C | SER555 |
| C | 1VW701 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT C 703 |
| Chain | Residue |
| C | ARG483 |
| C | SER508 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | CYS434 | |
| B | CYS434 | |
| C | CYS434 | |
| Chain | Residue | Details |
| A | CYS434 | |
| B | CYS434 | |
| C | CYS434 | |
