4L78

Xenon Trapping and Statistical Coupling Analysis Uncover Regions Important for Structure and Function of Multidomain Protein StPurL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004642	molecular_function	phosphoribosylformylglycinamidine synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	BINDING SITE FOR RESIDUE ADP A 1301

Chain	Residue
A	VAL333
A	ALA678
A	ASP679
A	GLU718
A	ASN722
A	SER886
A	MG1302
A	MG1303
A	MG1304
A	HOH1440
A	HOH1454
A	THR386
A	HOH1467
A	HOH1479
A	HOH1486
A	HOH1491
A	HOH1531
A	HOH1542
A	HOH1561
A	HOH1592
A	HOH1660
A	HOH1663
A	GLY387
A	HOH1666
A	HOH1745
A	HOH2037
A	TYR388
A	PHE389
A	LYS649
A	LEU652
A	GLN668
A	PRO676

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1302

Chain	Residue
A	ASP679
A	ASN722
A	ASP884
A	ADP1301
A	HOH1440
A	HOH1491

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1303

Chain	Residue
A	GLU718
A	ADP1301
A	HOH1467
A	HOH1525
A	HOH1531
A	HOH2037

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1304

Chain	Residue
A	ADP1301
A	HOH1454
A	HOH1479
A	HOH1486
A	HOH1542

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 1305

Chain	Residue
A	TYR251

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MN A 1306

Chain	Residue
A	HIS835

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1307

Chain	Residue
A	HIS216
A	GLY504
A	ALA505
A	LYS776
A	HOH1842
A	HOH1845
A	HOH1995

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1308

Chain	Residue
A	HIS216
A	THR295
A	HIS296
A	ASN297
A	HIS298
A	SER778
A	HOH1484
A	HOH1608
A	HOH1725

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1309

Chain	Residue
A	TYR690
A	ARG812
A	LYS1228
A	VAL1229
A	HOH1585
A	HOH1805
A	HOH1829
A	HOH1867

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1310

Chain	Residue
A	GLN1176
A	GLN1183
A	GLY1184
A	MET1185
A	VAL1186
A	HOH1534
A	HOH1877

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1311

Chain	Residue
A	PRO1040
A	LYS1041
A	HIS1086
A	HOH2046
A	HOH2234

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1312

Chain	Residue
A	HIS1086
A	ARG1126
A	PRO1127
A	GLN1128
A	THR1129
A	HOH1514

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1313

Chain	Residue
A	ASN1113
A	ARG1115
A	HOH1478

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1314

Chain	Residue
A	HOH1541
A	HOH1582
A	HOH1899
A	HOH2219
A	TRP305
A	ARG1159
A	ARG1164

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1315

Chain	Residue
A	SER12
A	ALA13
A	PHE14
A	ASN998
A	HIS1161
A	HOH2213

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1316

Chain	Residue
A	PRO356
A	GLU357
A	ARG358
A	HOH2257

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1317

Chain	Residue
A	THR632
A	ILE633
A	HOH1733
A	HOH2042

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1318

Chain	Residue
A	ALA911
A	HIS953
A	HOH1656
A	HOH2055

---

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE XE A 1319

Chain	Residue
A	LEU1088

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE XE A 1320

Chain	Residue
A	ILE417
A	THR683
A	GLU693
A	MET695

---

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE XE A 1323

Chain	Residue
A	GLU3
A	LEU5
A	ALA41

---

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1324

Chain	Residue
A	ARG22
A	ALA26
A	GLU130

---

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1325

Chain	Residue
A	HIS298

---

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1326

Chain	Residue
A	GLN211

---

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 1327

Chain	Residue
A	GLU582
A	GLU583

---

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 1328

Chain	Residue
A	HIS68
A	THR69

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15301531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22683785","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24223728","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---