Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4L5C

Methylthioadenosine phosphorylase from Schistosoma mansoni in complex with adenine in space group P212121

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0009116	biological_process	nucleoside metabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
A	0019509	biological_process	L-methionine salvage from methylthioadenosine
B	0003824	molecular_function	catalytic activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0009116	biological_process	nucleoside metabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
B	0019509	biological_process	L-methionine salvage from methylthioadenosine
C	0003824	molecular_function	catalytic activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0009116	biological_process	nucleoside metabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
C	0019509	biological_process	L-methionine salvage from methylthioadenosine
D	0003824	molecular_function	catalytic activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006166	biological_process	purine ribonucleoside salvage
D	0009116	biological_process	nucleoside metabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
D	0019509	biological_process	L-methionine salvage from methylthioadenosine
E	0003824	molecular_function	catalytic activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006166	biological_process	purine ribonucleoside salvage
E	0009116	biological_process	nucleoside metabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
E	0019509	biological_process	L-methionine salvage from methylthioadenosine
F	0003824	molecular_function	catalytic activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006166	biological_process	purine ribonucleoside salvage
F	0009116	biological_process	nucleoside metabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
F	0019509	biological_process	L-methionine salvage from methylthioadenosine

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADE A 301

Chain	Residue
A	ALA88
A	HOH403
A	CYS89
A	GLY90
A	PHE187
A	THR229
A	ASP230
A	ASP232
A	VAL246
A	GOL302

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 302

Chain	Residue
A	SER12
A	ALA88
A	PHE187
A	MET206
A	VAL246
A	ADE301
A	HOH406
A	HOH429
B	GLN289

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADE B 301

Chain	Residue
B	ALA88
B	CYS89
B	GLY90
B	VAL204
B	MET206
B	THR229
B	ASP230
B	ASP232
B	VAL246
B	GOL302
B	HOH407

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 302

Chain	Residue
B	SER12
B	MET206
B	VAL246
B	ADE301
B	HOH446
B	HOH461
C	HIS131
C	GLN289

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ADE C 301

Chain	Residue
C	ALA88
C	CYS89
C	GLY90
C	ASN205
C	THR229
C	ASP230
C	ASP232
C	GOL302
C	HOH407

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL C 302

Chain	Residue
A	GLN289
C	SER12
C	ALA88
C	PHE187
C	MET206
C	VAL246
C	ADE301
C	HOH412
C	HOH430

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADE D 301

Chain	Residue
D	ALA88
D	CYS89
D	GLY90
D	VAL204
D	THR229
D	ASP230
D	ASP232
D	VAL246
D	GOL302
D	HOH402
D	HOH407

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL D 302

Chain	Residue
D	SER12
D	ALA88
D	PHE187
D	MET206
D	VAL246
D	ADE301
D	HOH402
D	HOH459
F	GLN289

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL D 303

Chain	Residue
D	GLN289
E	SER12
E	ALA88
E	MET206
E	VAL246
E	ADE301
E	HOH483

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADE E 301

Chain	Residue
D	GOL303
E	ALA88
E	CYS89
E	GLY90
E	VAL204
E	ASN205
E	MET206
E	THR229
E	ASP230
E	ASP232
E	HOH403

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL E 302

Chain	Residue
F	VAL246
F	ADE301
F	HOH408
F	HOH469
E	HIS131
E	GLN289
F	SER12
F	PHE187
F	MET206

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADE F 301

Chain	Residue
E	GOL302
F	ALA88
F	CYS89
F	GLY90
F	PHE187
F	ASN205
F	THR229
F	ASP230
F	ASP232
F	HOH401

Functional Information from PROSITE/UniProt

site_id	PS01240
Number of Residues	41
Details	PNP_MTAP_2 Purine and other phosphorylases family 2 signature. LprhGkgHlIppseVnyrAn.VwAlkdlGcth.ILatNAcGSL

Chain	Residue	Details
A	LEU52-LEU92

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)