4L3H
Crystal Structure of the E113Q-MauG/pre-Methylamine Dehydrogenase Complex After Treatment with Hydrogen Peroxide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004130 | molecular_function | cytochrome-c peroxidase activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004130 | molecular_function | cytochrome-c peroxidase activity |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0009308 | biological_process | amine metabolic process |
| C | 0016638 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors |
| C | 0030058 | molecular_function | amine dehydrogenase activity |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0052876 | molecular_function | methylamine dehydrogenase (amicyanin) activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0030058 | molecular_function | amine dehydrogenase activity |
| D | 0030416 | biological_process | methylamine metabolic process |
| D | 0042597 | cellular_component | periplasmic space |
| D | 0052876 | molecular_function | methylamine dehydrogenase (amicyanin) activity |
| E | 0009308 | biological_process | amine metabolic process |
| E | 0016638 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors |
| E | 0030058 | molecular_function | amine dehydrogenase activity |
| E | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| E | 0042597 | cellular_component | periplasmic space |
| E | 0052876 | molecular_function | methylamine dehydrogenase (amicyanin) activity |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0030058 | molecular_function | amine dehydrogenase activity |
| F | 0030416 | biological_process | methylamine metabolic process |
| F | 0042597 | cellular_component | periplasmic space |
| F | 0052876 | molecular_function | methylamine dehydrogenase (amicyanin) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 401 |
| Chain | Residue |
| A | ASN66 |
| A | THR275 |
| A | PRO277 |
| A | HOH517 |
| A | HOH522 |
| A | HOH550 |
| A | HOH570 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEC A 402 |
| Chain | Residue |
| A | CYS31 |
| A | CYS34 |
| A | HIS35 |
| A | VAL55 |
| A | ARG65 |
| A | THR67 |
| A | PRO68 |
| A | LEU70 |
| A | GLN91 |
| A | PHE92 |
| A | TRP93 |
| A | ARG96 |
| A | LEU100 |
| A | GLN103 |
| A | ALA104 |
| A | PRO107 |
| A | GLN113 |
| A | MET114 |
| A | GLN163 |
| A | LYS265 |
| A | HOH671 |
| A | HOH712 |
| A | GLN29 |
| A | SER30 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE HEC A 403 |
| Chain | Residue |
| A | ASN200 |
| A | CYS201 |
| A | CYS204 |
| A | HIS205 |
| A | HIS224 |
| A | LEU228 |
| A | PHE264 |
| A | PRO267 |
| A | LEU269 |
| A | TYR278 |
| A | MET279 |
| A | HIS280 |
| A | LEU287 |
| A | TYR294 |
| A | HOH516 |
| A | HOH537 |
| A | HOH550 |
| A | HOH555 |
| A | HOH570 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 404 |
| Chain | Residue |
| A | LEU250 |
| A | ARG252 |
| A | ILE255 |
| A | HOH607 |
| A | HOH681 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 405 |
| Chain | Residue |
| A | ASN231 |
| A | THR233 |
| A | HOH518 |
| A | HOH538 |
| A | HOH680 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 401 |
| Chain | Residue |
| B | ASN66 |
| B | THR275 |
| B | PRO277 |
| B | HOH501 |
| B | HOH511 |
| B | HOH513 |
| B | HOH517 |
| site_id | AC7 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE HEC B 402 |
| Chain | Residue |
| B | GLN29 |
| B | SER30 |
| B | CYS31 |
| B | CYS34 |
| B | HIS35 |
| B | ARG65 |
| B | THR67 |
| B | PRO68 |
| B | LEU70 |
| B | GLN91 |
| B | PHE92 |
| B | TRP93 |
| B | ARG96 |
| B | LEU100 |
| B | GLN103 |
| B | ALA104 |
| B | PRO107 |
| B | GLN113 |
| B | MET114 |
| B | GLN163 |
| B | LYS265 |
| B | HOH510 |
| B | HOH702 |
| B | HOH727 |
| B | HOH754 |
| B | HOH861 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE HEC B 403 |
| Chain | Residue |
| B | PHE264 |
| B | PRO267 |
| B | LEU269 |
| B | TYR278 |
| B | MET279 |
| B | HIS280 |
| B | LEU287 |
| B | TYR294 |
| B | GLU327 |
| B | HOH509 |
| B | HOH513 |
| B | HOH517 |
| B | HOH565 |
| B | HOH582 |
| B | ASN200 |
| B | CYS201 |
| B | CYS204 |
| B | HIS205 |
| B | HIS224 |
| B | LEU228 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EDO B 404 |
| Chain | Residue |
| B | PRO313 |
| B | GLY315 |
| B | GLU316 |
| B | HOH627 |
| B | HOH674 |
| B | HOH722 |
| B | HOH846 |
| B | HOH851 |
| E | PRO15 |
| E | PRO64 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 405 |
| Chain | Residue |
| B | ARG202 |
| B | LEU203 |
| B | MET206 |
| B | ARG208 |
| B | LYS209 |
| B | ASN220 |
| B | HOH679 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 406 |
| Chain | Residue |
| B | ALA164 |
| B | ARG215 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 407 |
| Chain | Residue |
| B | ASN231 |
| B | THR233 |
| B | HOH630 |
| B | HOH731 |
| B | HOH816 |
| B | HOH824 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 408 |
| Chain | Residue |
| B | LEU250 |
| B | ARG252 |
| B | ILE255 |
| B | HOH637 |
| B | HOH661 |
| B | HOH831 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MES D 401 |
| Chain | Residue |
| A | GLU137 |
| A | ALA138 |
| A | LEU139 |
| A | GLY141 |
| D | ARG35 |
| D | LEU37 |
| D | GLU38 |
| D | HOH633 |
| site_id | BC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO D 402 |
| Chain | Residue |
| D | TYR138 |
| D | PRO139 |
| D | TRP140 |
| D | HIS183 |
| D | ASN229 |
| D | HIS230 |
| D | PRO231 |
| D | HOH749 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MES F 401 |
| Chain | Residue |
| B | ALA138 |
| B | LEU139 |
| B | PHE140 |
| B | GLY141 |
| F | ARG35 |
| F | LEU37 |
| F | GLU38 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE F 402 |
| Chain | Residue |
| D | GLU342 |
| F | THR187 |
| F | GLN235 |
| F | LYS236 |
| F | SER255 |
| F | SER256 |
| F | GLY257 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: covalent => ECO:0000255|PROSITE-ProRule:PRU00433 |
| Chain | Residue | Details |
| A | CYS31 | |
| A | CYS34 | |
| A | CYS201 | |
| A | CYS204 | |
| B | CYS31 | |
| B | CYS34 | |
| B | CYS201 | |
| B | CYS204 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: axial binding residue => ECO:0000255|PROSITE-ProRule:PRU00433 |
| Chain | Residue | Details |
| A | HIS35 | |
| A | HIS205 | |
| A | HIS280 | |
| B | HIS35 | |
| B | HIS205 | |
| B | HIS280 |
