Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4L0O

Structure determination of cystathionine gamma-synthase from Helicobacter pylori

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003962	molecular_function	cystathionine gamma-synthase activity
A	0004123	molecular_function	cystathionine gamma-lyase activity
A	0005737	cellular_component	cytoplasm
A	0009086	biological_process	methionine biosynthetic process
A	0016740	molecular_function	transferase activity
A	0019343	biological_process	cysteine biosynthetic process via cystathionine
A	0019346	biological_process	transsulfuration
A	0030170	molecular_function	pyridoxal phosphate binding
A	0102028	molecular_function	cystathionine gamma-synthase activity (acts on O-phosphohomoserine)
C	0003962	molecular_function	cystathionine gamma-synthase activity
C	0004123	molecular_function	cystathionine gamma-lyase activity
C	0005737	cellular_component	cytoplasm
C	0009086	biological_process	methionine biosynthetic process
C	0016740	molecular_function	transferase activity
C	0019343	biological_process	cysteine biosynthetic process via cystathionine
C	0019346	biological_process	transsulfuration
C	0030170	molecular_function	pyridoxal phosphate binding
C	0102028	molecular_function	cystathionine gamma-synthase activity (acts on O-phosphohomoserine)
E	0003962	molecular_function	cystathionine gamma-synthase activity
E	0004123	molecular_function	cystathionine gamma-lyase activity
E	0005737	cellular_component	cytoplasm
E	0009086	biological_process	methionine biosynthetic process
E	0016740	molecular_function	transferase activity
E	0019343	biological_process	cysteine biosynthetic process via cystathionine
E	0019346	biological_process	transsulfuration
E	0030170	molecular_function	pyridoxal phosphate binding
E	0102028	molecular_function	cystathionine gamma-synthase activity (acts on O-phosphohomoserine)
G	0003962	molecular_function	cystathionine gamma-synthase activity
G	0004123	molecular_function	cystathionine gamma-lyase activity
G	0005737	cellular_component	cytoplasm
G	0009086	biological_process	methionine biosynthetic process
G	0016740	molecular_function	transferase activity
G	0019343	biological_process	cysteine biosynthetic process via cystathionine
G	0019346	biological_process	transsulfuration
G	0030170	molecular_function	pyridoxal phosphate binding
G	0102028	molecular_function	cystathionine gamma-synthase activity (acts on O-phosphohomoserine)
H	0003962	molecular_function	cystathionine gamma-synthase activity
H	0004123	molecular_function	cystathionine gamma-lyase activity
H	0005737	cellular_component	cytoplasm
H	0009086	biological_process	methionine biosynthetic process
H	0016740	molecular_function	transferase activity
H	0019343	biological_process	cysteine biosynthetic process via cystathionine
H	0019346	biological_process	transsulfuration
H	0030170	molecular_function	pyridoxal phosphate binding
H	0102028	molecular_function	cystathionine gamma-synthase activity (acts on O-phosphohomoserine)
K	0003962	molecular_function	cystathionine gamma-synthase activity
K	0004123	molecular_function	cystathionine gamma-lyase activity
K	0005737	cellular_component	cytoplasm
K	0009086	biological_process	methionine biosynthetic process
K	0016740	molecular_function	transferase activity
K	0019343	biological_process	cysteine biosynthetic process via cystathionine
K	0019346	biological_process	transsulfuration
K	0030170	molecular_function	pyridoxal phosphate binding
K	0102028	molecular_function	cystathionine gamma-synthase activity (acts on O-phosphohomoserine)
M	0003962	molecular_function	cystathionine gamma-synthase activity
M	0004123	molecular_function	cystathionine gamma-lyase activity
M	0005737	cellular_component	cytoplasm
M	0009086	biological_process	methionine biosynthetic process
M	0016740	molecular_function	transferase activity
M	0019343	biological_process	cysteine biosynthetic process via cystathionine
M	0019346	biological_process	transsulfuration
M	0030170	molecular_function	pyridoxal phosphate binding
M	0102028	molecular_function	cystathionine gamma-synthase activity (acts on O-phosphohomoserine)
O	0003962	molecular_function	cystathionine gamma-synthase activity
O	0004123	molecular_function	cystathionine gamma-lyase activity
O	0005737	cellular_component	cytoplasm
O	0009086	biological_process	methionine biosynthetic process
O	0016740	molecular_function	transferase activity
O	0019343	biological_process	cysteine biosynthetic process via cystathionine
O	0019346	biological_process	transsulfuration
O	0030170	molecular_function	pyridoxal phosphate binding
O	0102028	molecular_function	cystathionine gamma-synthase activity (acts on O-phosphohomoserine)

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PLP H 401

Chain	Residue
E	ARG46
H	LYS195
H	SER73
H	GLY74
H	LEU75
H	TYR98
H	ASP170
H	THR172
H	SER192
H	THR194

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PLP A 401

Chain	Residue
A	SER73
A	GLY74
A	LEU75
A	TYR98
A	ASP170
A	THR172
A	PHE173
A	SER192
A	THR194
A	LYS195
C	TYR44
C	ARG46

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PLP C 401

Chain	Residue
A	TYR44
A	ARG46
C	SER73
C	GLY74
C	LEU75
C	TYR98
C	ASP170
C	SER192
C	THR194
C	LYS195

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PLP E 401

Chain	Residue
E	SER73
E	GLY74
E	LEU75
E	ASP170
E	SER192
E	THR194
E	LYS195
E	ALA205
H	TYR44
H	ARG46

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PLP G 401

Chain	Residue
G	SER73
G	GLY74
G	LEU75
G	TYR98
G	ASP170
G	THR172
G	SER192
G	THR194
G	LYS195
K	TYR44
K	ARG46

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 K 401

Chain	Residue
G	TYR44
G	ARG46
K	SER73
K	GLY74
K	LEU75
K	SER192
K	THR194
K	ALA205

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PLP M 401

Chain	Residue
M	SER73
M	GLY74
M	LEU75
M	TYR98
M	ASP170
M	PHE173
M	SER192
M	THR194
M	LYS195
O	TYR44
O	ARG46

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PLP O 401

Chain	Residue
M	TYR44
M	ARG46
O	SER73
O	GLY74
O	LEU75
O	TYR98
O	ASP170
O	SER192
O	THR194
O	LYS195

Functional Information from PROSITE/UniProt

site_id	PS00868
Number of Residues	15
Details	CYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DIvahSGTKYLgGHS

Chain	Residue	Details
H	ASP187-SER201

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250

Chain	Residue	Details
H	LYS195
A	LYS195
C	LYS195
E	LYS195
G	LYS195
K	LYS195
M	LYS195
O	LYS195

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)