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4L0I

Tankyrase 2 catalytic domain in complex with ethyl 4-(4-oxo-4H-chromen-2-yl)benzoate

Functional Information from GO Data
ChainGOidnamespacecontents
A0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
B0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
C0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
D0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 1UW A 1201
ChainResidue
AHIS1031
ATYR1071
AILE1075
CGLU1138
AGLY1032
APHE1035
AALA1049
ATYR1050
ATYR1060
AALA1062
ALYS1067
ASER1068

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1202
ChainResidue
ACYS1081
AHIS1084
ACYS1089
ACYS1092

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1203
ChainResidue
AARG977
AHIS979
AARG980
ALYS1067
AGLN1070

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1204
ChainResidue
AASN990
AARG991
CPRO1160
CGLU1161
CHOH1205

site_idAC5
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 1UW B 1201
ChainResidue
BHIS1031
BGLY1032
BPHE1035
BALA1049
BTYR1050
BTYR1060
BALA1062
BLYS1067
BSER1068
BTYR1071
DGLU1138

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 1202
ChainResidue
BCYS1081
BHIS1084
BCYS1089
BCYS1092

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 1203
ChainResidue
BARG977
BHIS979
BARG980
BLYS1067
BGLN1070
BHOH1301
BHOH1339

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 1204
ChainResidue
BASN990
BARG991
DPRO1160
DGLU1161
DHOH1205

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:O95271
ChainResidueDetails
ACYS1081
AHIS1084
ACYS1089
ACYS1092
BCYS1081
BHIS1084
BCYS1089
BCYS1092

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PDB entries from 2024-11-13

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