Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4KXH

The X-ray crystal structure of a dimeric variant of human pancreatic ribonuclease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004522	molecular_function	ribonuclease A activity
A	0004540	molecular_function	RNA nuclease activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051607	biological_process	defense response to virus
A	0070062	cellular_component	extracellular exosome
B	0003676	molecular_function	nucleic acid binding
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004522	molecular_function	ribonuclease A activity
B	0004540	molecular_function	RNA nuclease activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0051607	biological_process	defense response to virus
B	0070062	cellular_component	extracellular exosome
C	0003676	molecular_function	nucleic acid binding
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0004522	molecular_function	ribonuclease A activity
C	0004540	molecular_function	RNA nuclease activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0016787	molecular_function	hydrolase activity
C	0016829	molecular_function	lyase activity
C	0050830	biological_process	defense response to Gram-positive bacterium
C	0051607	biological_process	defense response to virus
C	0070062	cellular_component	extracellular exosome
D	0003676	molecular_function	nucleic acid binding
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004522	molecular_function	ribonuclease A activity
D	0004540	molecular_function	RNA nuclease activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0016787	molecular_function	hydrolase activity
D	0016829	molecular_function	lyase activity
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0051607	biological_process	defense response to virus
D	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 201

Chain	Residue
A	HIS119
A	PHE120
A	HOH354
B	GLN11
B	HIS12

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 202

Chain	Residue
A	ARG32
A	ARG33

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 201

Chain	Residue
B	HIS119
B	PHE120
B	HOH316
B	HOH329
A	GLN11
A	HIS12

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 202

Chain	Residue
A	HIS12
B	LYS41
B	VAL43
B	ASN44
B	THR45
B	PHE120
B	HOH329

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 203

Chain	Residue
B	ARG32
B	ARG33
B	HOH310
B	HOH346

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 204

Chain	Residue
B	ARG32
D	SER113

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 205

Chain	Residue
A	HOH306
A	HOH315
B	LEU51
B	HOH324
C	LEU51

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 201

Chain	Residue
C	LYS41
C	HIS119
C	PHE120
C	HOH324
D	GLN11
D	HIS12

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 202

Chain	Residue
C	GLN11
C	HIS12
D	LYS41
D	HIS119
D	PHE120

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 203

Chain	Residue
C	ARG32
C	ARG33

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 204

Chain	Residue
B	ARG91
C	ARG10
C	GLN11
D	ASN34
D	ARG39
D	HOH305

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 205

Chain	Residue
A	ARG91
C	ASN34
C	ARG39
C	HOH322

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA C 206

Chain	Residue
A	HOH313
A	HOH320
A	HOH325
C	GLN28

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 207

Chain	Residue
C	TYR92

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 201

Chain	Residue
B	LYS6
D	ARG32
D	ARG33
D	HOH325

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 202

Chain	Residue
D	ARG85
D	THR87
D	ASN88
D	ARG98
D	HOH324

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA D 203

Chain	Residue
A	PRO50
A	LEU51
A	HOH301
C	HOH337
D	HOH340

Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF

Chain	Residue	Details
A	CYS40-PHE46

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton donor"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; partial","evidences":[{"source":"PubMed","id":"3202829","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"3202829","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)