4KX9
Crystal structure of human aminopeptidase A complexed with arginine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0002003 | biological_process | angiotensin maturation |
| A | 0003081 | biological_process | regulation of systemic arterial blood pressure by renin-angiotensin |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0004230 | molecular_function | glutamyl aminopeptidase activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005903 | cellular_component | brush border |
| A | 0006508 | biological_process | proteolysis |
| A | 0007267 | biological_process | cell-cell signaling |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008283 | biological_process | cell population proliferation |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016477 | biological_process | cell migration |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0032835 | biological_process | glomerulus development |
| A | 0043171 | biological_process | peptide catabolic process |
| A | 0045177 | cellular_component | apical part of cell |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| A | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELVHQW |
| Chain | Residue | Details |
| A | VAL390-TRP399 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23888046","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23888046","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23888046","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KXA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23888046","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23888046","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KXA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Binds calcium which modulates its enzyme activity","evidences":[{"source":"PubMed","id":"23888046","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"23888046","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; atypical","evidences":[{"source":"PubMed","id":"23888046","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KX7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23888046","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23888046","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23888046","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23888046","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23888046","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
