Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4KVO

The NatA (Naa10p/Naa15p) amino-terminal acetyltrasferase complex bound to AcCoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0010698	molecular_function	acetyltransferase activator activity
A	0031415	cellular_component	NatA complex
A	0051604	biological_process	protein maturation
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0010698	molecular_function	acetyltransferase activator activity
B	0031415	cellular_component	NatA complex
B	0051604	biological_process	protein maturation
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0010698	molecular_function	acetyltransferase activator activity
C	0031415	cellular_component	NatA complex
C	0051604	biological_process	protein maturation
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0010698	molecular_function	acetyltransferase activator activity
D	0031415	cellular_component	NatA complex
D	0051604	biological_process	protein maturation
E	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
E	0006474	biological_process	N-terminal protein amino acid acetylation
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0031415	cellular_component	NatA complex
F	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
F	0006474	biological_process	N-terminal protein amino acid acetylation
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0031415	cellular_component	NatA complex
G	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
G	0006474	biological_process	N-terminal protein amino acid acetylation
G	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
G	0031415	cellular_component	NatA complex
H	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
H	0006474	biological_process	N-terminal protein amino acid acetylation
H	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
H	0031415	cellular_component	NatA complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 802

Chain	Residue
A	SER123
A	LEU131
A	ARG135
A	PHE538
A	TYR546

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 804

Chain	Residue
A	ARG146
A	SER150

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 805

Chain	Residue
A	LYS129
A	ARG159

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 806

Chain	Residue
A	LYS201

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 807

Chain	Residue
A	ASN261
A	ARG264

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 808

Chain	Residue
A	GLU307
A	GLY308
A	LYS342

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 809

Chain	Residue
A	ARG422
A	LYS453
A	LYS456
A	TYR457

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 810

Chain	Residue
A	LYS425

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 812

Chain	Residue
A	ARG221
A	LEU247
A	ARG251

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 802

Chain	Residue
B	LYS92
B	TYR94

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 803

Chain	Residue
B	ASP528
B	PHE531
F	LYS29

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 804

Chain	Residue
B	ARG116

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 805

Chain	Residue
B	PHE535

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 806

Chain	Residue
B	LYS129
C	LYS725

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 807

Chain	Residue
B	ARG146
B	SER150

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 808

Chain	Residue
B	ARG422
B	LYS453
B	TYR457
B	CL810

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 809

Chain	Residue
B	LYS425
B	ARG460

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 810

Chain	Residue
B	CL808

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 812

Chain	Residue
B	HIS439

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 813

Chain	Residue
B	ARG460
B	LYS501

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 801

Chain	Residue
C	ARG89
C	ASP117
C	LEU120

site_id	CC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 802

Chain	Residue
C	ARG116

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 803

Chain	Residue
C	LEU131
C	ARG135
C	ALA151
C	ALA155
C	PHE538

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 804

Chain	Residue
C	ARG539

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 805

Chain	Residue
C	ARG146
C	SER150

site_id	CC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 806

Chain	Residue
C	LYS201

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 808

Chain	Residue
C	ARG422
C	LYS453
C	LYS456
C	TYR457
C	CL810

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 809

Chain	Residue
C	LYS425
C	ARG460

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 810

Chain	Residue
C	ARG422
C	CL808

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 811

Chain	Residue
C	MET496
C	ARG515
C	THR518

site_id	DC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 813

Chain	Residue
C	ARG422
C	HIS426

site_id	DC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 815

Chain	Residue
C	GLY308
C	LYS342

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA D 801

Chain	Residue
D	GLN491
D	THR525
D	ASP529
H	GLN27
H	LYS29

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 803

Chain	Residue
D	LEU131
D	ARG135
D	PHE538

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 804

Chain	Residue
D	TYR162
D	ALA163
D	LYS201

site_id	DC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 805

Chain	Residue
D	GLU215
D	VAL218
D	ARG221

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 806

Chain	Residue
D	GLN263
D	GLU269
D	TRP281
D	LYS305

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL D 807

Chain	Residue
D	ARG422
D	LYS453
D	LYS456
D	TYR457
D	CL808

site_id	EC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 808

Chain	Residue
D	LYS425
D	CL807
D	CL809

site_id	EC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 809

Chain	Residue
D	ARG422
D	CL808

site_id	EC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 810

Chain	Residue
D	MET496
D	ARG515
D	THR518

site_id	EC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 811

Chain	Residue
D	LYS237

site_id	EC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 812

Chain	Residue
D	ARG221
D	ARG251

site_id	EC8
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ACO E 201

Chain	Residue
A	GLU42
E	ASN21
E	LEU22
E	SER75
E	VAL76
E	SER77
E	VAL78
E	ARG83
E	HIS84
E	LEU85
E	GLY86
E	LEU87
E	ALA88
E	LYS89
E	HIS111
E	VAL112
E	ASN116
E	ALA118
E	LEU122
E	TYR123
E	THR126

site_id	EC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA E 202

Chain	Residue
E	GLN15
E	ASN18
E	ASN25
E	TYR26
E	TYR31

site_id	FC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA E 203

Chain	Residue
E	ASP141

site_id	FC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 205

Chain	Residue
E	TRP38

site_id	FC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 206

Chain	Residue
E	ARG4
E	THR46
E	GLY50

site_id	FC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 208

Chain	Residue
E	LEU19

site_id	FC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 209

Chain	Residue
E	LYS59
E	GLU61

site_id	FC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 210

Chain	Residue
E	LYS89
E	THR126

site_id	FC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ACO F 201

Chain	Residue
F	ASN21
F	LEU22
F	VAL76
F	VAL78
F	ARG83
F	HIS84
F	LEU85
F	GLY86
F	LEU87
F	ALA88
F	HIS111
F	VAL112
F	ASN116
F	TYR123
F	THR126

site_id	FC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL F 203

Chain	Residue
B	ARG448
F	LEU19

site_id	FC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ACO G 201

Chain	Residue
G	ASN21
G	LEU22
G	VAL76
G	SER77
G	VAL78
G	ARG83
G	HIS84
G	LEU85
G	GLY86
G	LEU87
G	ALA88
G	LYS89
G	HIS111
G	VAL112
G	ASN116
G	HIS121
G	TYR123
G	THR126

site_id	GC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA G 202

Chain	Residue
G	ILE120
G	ASP125

site_id	GC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 203

Chain	Residue
A	ALA731
G	LYS29

site_id	GC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 204

Chain	Residue
C	ARG448
G	LEU19

site_id	GC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ACO H 201

Chain	Residue
D	GLU42
H	ASN21
H	LEU22
H	GLU24
H	VAL76
H	SER77
H	VAL78
H	ARG83
H	HIS84
H	GLY86
H	LEU87
H	ALA88
H	LYS89
H	HIS111
H	VAL112
H	ASN116
H	ARG117
H	ALA118
H	LEU122
H	TYR123

site_id	GC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 203

Chain	Residue
C	GLN372
C	ILE373

site_id	GC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 204

Chain	Residue
D	ARG448
H	LEU19

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	132
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	128
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	132
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	144
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	132
Details	Repeat: {"description":"TPR 5"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	132
Details	Repeat: {"description":"TPR 6"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	128
Details	Repeat: {"description":"TPR 7"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	132
Details	Repeat: {"description":"TPR 8"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	132
Details	Repeat: {"description":"TPR 9"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	608
Details	Domain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)