Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4KUH

Crystal structure of 3-hydroxybutylryl-CoA dehydrogenase with acetoacetyl-CoA from Clostridium butyricum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
A	0009056	biological_process	catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019605	biological_process	butyrate metabolic process
A	0070403	molecular_function	NAD+ binding
B	0000166	molecular_function	nucleotide binding
B	0006631	biological_process	fatty acid metabolic process
B	0006635	biological_process	fatty acid beta-oxidation
B	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
B	0009056	biological_process	catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019605	biological_process	butyrate metabolic process
B	0070403	molecular_function	NAD+ binding
C	0000166	molecular_function	nucleotide binding
C	0006631	biological_process	fatty acid metabolic process
C	0006635	biological_process	fatty acid beta-oxidation
C	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
C	0009056	biological_process	catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019605	biological_process	butyrate metabolic process
C	0070403	molecular_function	NAD+ binding
D	0000166	molecular_function	nucleotide binding
D	0006631	biological_process	fatty acid metabolic process
D	0006635	biological_process	fatty acid beta-oxidation
D	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
D	0009056	biological_process	catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019605	biological_process	butyrate metabolic process
D	0070403	molecular_function	NAD+ binding
E	0000166	molecular_function	nucleotide binding
E	0006631	biological_process	fatty acid metabolic process
E	0006635	biological_process	fatty acid beta-oxidation
E	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
E	0009056	biological_process	catabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0019605	biological_process	butyrate metabolic process
E	0070403	molecular_function	NAD+ binding
F	0000166	molecular_function	nucleotide binding
F	0006631	biological_process	fatty acid metabolic process
F	0006635	biological_process	fatty acid beta-oxidation
F	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
F	0009056	biological_process	catabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0019605	biological_process	butyrate metabolic process
F	0070403	molecular_function	NAD+ binding
G	0000166	molecular_function	nucleotide binding
G	0006631	biological_process	fatty acid metabolic process
G	0006635	biological_process	fatty acid beta-oxidation
G	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
G	0009056	biological_process	catabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0019605	biological_process	butyrate metabolic process
G	0070403	molecular_function	NAD+ binding
H	0000166	molecular_function	nucleotide binding
H	0006631	biological_process	fatty acid metabolic process
H	0006635	biological_process	fatty acid beta-oxidation
H	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
H	0009056	biological_process	catabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0019605	biological_process	butyrate metabolic process
H	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CAA A 301

Chain	Residue
A	LYS50
A	LEU191
A	MET224
A	HOH413
B	GLY219
B	ASN221
A	LEU51
A	LYS54
A	LYS56
A	SER117
A	HIS138
A	PHE140
A	ASN141
A	ASN188

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CAA C 301

Chain	Residue
C	LYS50
C	LEU51
C	LYS54
C	LYS56
C	SER117
C	HIS138
C	PHE140
C	ASN141
C	ASN188
C	LEU191
C	MET224
D	GLY219
D	ASN221

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CAA E 301

Chain	Residue
E	LYS50
E	LYS54
E	LYS56
E	SER117
E	HIS138
E	PHE140
E	ASN141
E	ASN188
E	PRO223
E	MET224
E	LEU229
F	GLY219
F	ASN221

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CAA F 301

Chain	Residue
E	GLY219
E	ASN221
F	LYS50
F	LYS56
F	SER117
F	HIS138
F	PHE139
F	PHE140
F	ASN141
F	ASN188
F	LEU191
F	PRO223
F	MET224
F	LEU229
F	ILE233
F	HOH411

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE CAA H 301

Chain	Residue
G	GLY219
G	ASN221
H	LYS50
H	LEU51
H	LYS56
H	SER117
H	HIS138
H	PHE139
H	PHE140
H	ASN141
H	VAL145
H	ASN188
H	PRO223
H	MET224
H	LEU229
H	ILE233
H	VAL237

Functional Information from PROSITE/UniProt

site_id	PS00067
Number of Residues	25
Details	3HCDH 3-hydroxyacyl-CoA dehydrogenase signature. EapGFVvNRiliPMIneatf.ILqeG

Chain	Residue	Details
A	GLU181-GLY205

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)