4KUG

Crystal structure of 3-hydroxybutylryl-CoA dehydrogenase with NAD from Clostridium butyricum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0006631	biological_process	fatty acid metabolic process
A	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019605	biological_process	butyrate metabolic process
A	0044248	biological_process	cellular catabolic process
A	0070403	molecular_function	NAD+ binding
B	0000166	molecular_function	nucleotide binding
B	0006631	biological_process	fatty acid metabolic process
B	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019605	biological_process	butyrate metabolic process
B	0044248	biological_process	cellular catabolic process
B	0070403	molecular_function	NAD+ binding
C	0000166	molecular_function	nucleotide binding
C	0006631	biological_process	fatty acid metabolic process
C	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019605	biological_process	butyrate metabolic process
C	0044248	biological_process	cellular catabolic process
C	0070403	molecular_function	NAD+ binding
D	0000166	molecular_function	nucleotide binding
D	0006631	biological_process	fatty acid metabolic process
D	0008691	molecular_function	3-hydroxybutyryl-CoA dehydrogenase activity
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019605	biological_process	butyrate metabolic process
D	0044248	biological_process	cellular catabolic process
D	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE NAD A 301

Chain	Residue
A	GLY8
A	LYS95
A	ILE98
A	ASN115
A	THR116
A	SER117
A	HIS138
A	PHE139
A	HOH418
A	HOH426
A	HOH438
A	GLY10
A	HOH439
A	THR11
A	MET12
A	ARG30
A	ASP31
A	ALA87
A	ALA88
A	GLU90

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site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NAD B 301

Chain	Residue
B	GLY8
B	GLY10
B	THR11
B	MET12
B	ARG30
B	ASP31
B	ILE32
B	ALA87
B	ALA88
B	GLU90
B	LYS95
B	ILE98
B	ASN115
B	THR116
B	SER117
B	HIS138
B	PHE139
B	ASN141
B	HOH416

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NAD C 301

Chain	Residue
C	ALA9
C	GLY10
C	THR11
C	MET12
C	ARG30
C	ASP31
C	ILE32
C	PHE36
C	ALA87
C	ALA88
C	ILE89
C	GLU90
C	LYS95
C	ASN115
C	THR116
C	SER117
C	HIS138
C	PHE139
C	ASN141

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site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NAD D 301

Chain	Residue
D	GLY8
D	GLY10
D	THR11
D	MET12
D	ARG30
D	ASP31
D	ILE32
D	ALA87
D	ALA88
D	GLU90
D	LYS95
D	ILE98
D	ASN115
D	THR116
D	SER117
D	HIS138
D	PHE139
D	ASN141
D	HOH454

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Functional Information from PROSITE/UniProt

site_id	PS00067
Number of Residues	25
Details	3HCDH 3-hydroxyacyl-CoA dehydrogenase signature. EapGFVvNRiliPMIneatf.ILqeG

Chain	Residue	Details
A	GLU181-GLY205

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