4KRY
Structure of Aes from E. coli in covalent complex with PMS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008126 | molecular_function | acetylesterase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0034338 | molecular_function | short-chain carboxylesterase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008126 | molecular_function | acetylesterase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0034338 | molecular_function | short-chain carboxylesterase activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008126 | molecular_function | acetylesterase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0034338 | molecular_function | short-chain carboxylesterase activity |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0008126 | molecular_function | acetylesterase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0034338 | molecular_function | short-chain carboxylesterase activity |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0008126 | molecular_function | acetylesterase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0034338 | molecular_function | short-chain carboxylesterase activity |
| E | 0042803 | molecular_function | protein homodimerization activity |
| E | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0008126 | molecular_function | acetylesterase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0034338 | molecular_function | short-chain carboxylesterase activity |
| F | 0042803 | molecular_function | protein homodimerization activity |
| F | 0052689 | molecular_function | carboxylic ester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE A 401 |
| Chain | Residue |
| A | GLY199 |
| A | LEU200 |
| A | ARG206 |
| A | LEU221 |
| A | GLN222 |
| A | GLU225 |
| A | TYR240 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE A 402 |
| Chain | Residue |
| A | GLU73 |
| D | ALA140 |
| D | CYS143 |
| D | TYR144 |
| D | GLN147 |
| A | ALA62 |
| A | MET64 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IMD A 403 |
| Chain | Residue |
| A | TYR239 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE B 401 |
| Chain | Residue |
| B | LEU197 |
| B | GLY199 |
| B | LEU200 |
| B | ARG206 |
| B | GLU225 |
| B | TYR240 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IMD B 402 |
| Chain | Residue |
| B | LYS302 |
| B | ASP305 |
| B | GLU306 |
| C | LYS302 |
| C | ASP305 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PGE C 401 |
| Chain | Residue |
| C | LEU197 |
| C | GLY199 |
| C | LEU200 |
| C | ARG201 |
| C | ARG206 |
| C | LEU221 |
| C | GLU225 |
| C | TYR240 |
| C | ASP267 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGE D 401 |
| Chain | Residue |
| D | LEU197 |
| D | GLY199 |
| D | LEU200 |
| D | ARG201 |
| D | ARG206 |
| D | LEU221 |
| D | GLU225 |
| D | TYR240 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE D 402 |
| Chain | Residue |
| D | ASP122 |
| D | TYR123 |
| D | THR124 |
| D | LEU125 |
| D | GLU128 |
| D | HOH566 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 1PE D 403 |
| Chain | Residue |
| A | ASN99 |
| A | ASP101 |
| D | TRP177 |
| D | LYS181 |
| D | TYR239 |
| D | HOH598 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IMD D 404 |
| Chain | Residue |
| D | ASN99 |
| D | ASP101 |
| D | HOH526 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IMD D 405 |
| Chain | Residue |
| D | LYS302 |
| D | ASP305 |
| E | LYS302 |
| E | ASP305 |
| E | GLU306 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE E 401 |
| Chain | Residue |
| E | GLY199 |
| E | LEU200 |
| E | ARG206 |
| E | LEU221 |
| E | GLU225 |
| E | TYR240 |
| E | HOH534 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1PE E 402 |
| Chain | Residue |
| B | ALA62 |
| B | MET64 |
| B | GLU73 |
| E | ALA140 |
| E | CYS143 |
| E | TYR144 |
| E | GLN147 |
| E | ILE183 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE F 401 |
| Chain | Residue |
| F | LEU197 |
| F | GLY199 |
| F | LEU200 |
| F | ARG206 |
| F | LEU221 |
| F | TYR240 |
| F | ASP267 |
Functional Information from PROSITE/UniProt
| site_id | PS01173 |
| Number of Residues | 17 |
| Details | LIPASE_GDXG_HIS Lipolytic enzymes "G-D-X-G" family, putative histidine active site. LFyLHGGGFilgNldTH |
| Chain | Residue | Details |
| A | LEU87-HIS103 |
| site_id | PS01174 |
| Number of Residues | 13 |
| Details | LIPASE_GDXG_SER Lipolytic enzymes "G-D-X-G" family, putative serine active site. IgFAGDSAGAmLA |
| Chain | Residue | Details |
| A | ILE159-ALA171 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305 |
| Chain | Residue | Details |
| A | SEB165 | |
| D | SEB165 | |
| D | ASP262 | |
| D | HIS292 | |
| E | SEB165 | |
| E | ASP262 | |
| E | HIS292 | |
| F | SEB165 | |
| F | ASP262 | |
| F | HIS292 | |
| A | ASP262 | |
| A | HIS292 | |
| B | SEB165 | |
| B | ASP262 | |
| B | HIS292 | |
| C | SEB165 | |
| C | ASP262 | |
| C | HIS292 |
