4KRY

Structure of Aes from E. coli in covalent complex with PMS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0008126	molecular_function	acetylesterase activity
A	0016787	molecular_function	hydrolase activity
A	0034338	molecular_function	short-chain carboxylesterase activity
A	0042803	molecular_function	protein homodimerization activity
A	0052689	molecular_function	carboxylic ester hydrolase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0008126	molecular_function	acetylesterase activity
B	0016787	molecular_function	hydrolase activity
B	0034338	molecular_function	short-chain carboxylesterase activity
B	0042803	molecular_function	protein homodimerization activity
B	0052689	molecular_function	carboxylic ester hydrolase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0008126	molecular_function	acetylesterase activity
C	0016787	molecular_function	hydrolase activity
C	0034338	molecular_function	short-chain carboxylesterase activity
C	0042803	molecular_function	protein homodimerization activity
C	0052689	molecular_function	carboxylic ester hydrolase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0008126	molecular_function	acetylesterase activity
D	0016787	molecular_function	hydrolase activity
D	0034338	molecular_function	short-chain carboxylesterase activity
D	0042803	molecular_function	protein homodimerization activity
D	0052689	molecular_function	carboxylic ester hydrolase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0008126	molecular_function	acetylesterase activity
E	0016787	molecular_function	hydrolase activity
E	0034338	molecular_function	short-chain carboxylesterase activity
E	0042803	molecular_function	protein homodimerization activity
E	0052689	molecular_function	carboxylic ester hydrolase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0008126	molecular_function	acetylesterase activity
F	0016787	molecular_function	hydrolase activity
F	0034338	molecular_function	short-chain carboxylesterase activity
F	0042803	molecular_function	protein homodimerization activity
F	0052689	molecular_function	carboxylic ester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGE A 401

Chain	Residue
A	GLY199
A	LEU200
A	ARG206
A	LEU221
A	GLN222
A	GLU225
A	TYR240

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGE A 402

Chain	Residue
A	GLU73
D	ALA140
D	CYS143
D	TYR144
D	GLN147
A	ALA62
A	MET64

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IMD A 403

Chain	Residue
A	TYR239

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE B 401

Chain	Residue
B	LEU197
B	GLY199
B	LEU200
B	ARG206
B	GLU225
B	TYR240

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IMD B 402

Chain	Residue
B	LYS302
B	ASP305
B	GLU306
C	LYS302
C	ASP305

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PGE C 401

Chain	Residue
C	LEU197
C	GLY199
C	LEU200
C	ARG201
C	ARG206
C	LEU221
C	GLU225
C	TYR240
C	ASP267

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PGE D 401

Chain	Residue
D	LEU197
D	GLY199
D	LEU200
D	ARG201
D	ARG206
D	LEU221
D	GLU225
D	TYR240

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE D 402

Chain	Residue
D	ASP122
D	TYR123
D	THR124
D	LEU125
D	GLU128
D	HOH566

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE D 403

Chain	Residue
A	ASN99
A	ASP101
D	TRP177
D	LYS181
D	TYR239
D	HOH598

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IMD D 404

Chain	Residue
D	ASN99
D	ASP101
D	HOH526

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IMD D 405

Chain	Residue
D	LYS302
D	ASP305
E	LYS302
E	ASP305
E	GLU306

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGE E 401

Chain	Residue
E	GLY199
E	LEU200
E	ARG206
E	LEU221
E	GLU225
E	TYR240
E	HOH534

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 1PE E 402

Chain	Residue
B	ALA62
B	MET64
B	GLU73
E	ALA140
E	CYS143
E	TYR144
E	GLN147
E	ILE183

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGE F 401

Chain	Residue
F	LEU197
F	GLY199
F	LEU200
F	ARG206
F	LEU221
F	TYR240
F	ASP267

---

Functional Information from PROSITE/UniProt

site_id	PS01173
Number of Residues	17
Details	LIPASE_GDXG_HIS Lipolytic enzymes "G-D-X-G" family, putative histidine active site. LFyLHGGGFilgNldTH

Chain	Residue	Details
A	LEU87-HIS103

---

site_id	PS01174
Number of Residues	13
Details	LIPASE_GDXG_SER Lipolytic enzymes "G-D-X-G" family, putative serine active site. IgFAGDSAGAmLA

Chain	Residue	Details
A	ILE159-ALA171

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Motif: {"description":"Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole","evidences":[{"source":"UniProtKB","id":"Q5NUF3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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