4KR7
Crystal structure of a 4-thiouridine synthetase - RNA complex with bound ATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0002937 | biological_process | tRNA 4-thiouridine biosynthesis |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004810 | molecular_function | CCA tRNA nucleotidyltransferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| A | 0016783 | molecular_function | sulfurtransferase activity |
| A | 0034227 | biological_process | tRNA thio-modification |
| A | 0052837 | biological_process | thiazole biosynthetic process |
| A | 0140741 | molecular_function | tRNA-uracil-4 sulfurtransferase activity |
| A | 1990228 | cellular_component | sulfurtransferase complex |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0002937 | biological_process | tRNA 4-thiouridine biosynthesis |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004810 | molecular_function | CCA tRNA nucleotidyltransferase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| B | 0016783 | molecular_function | sulfurtransferase activity |
| B | 0034227 | biological_process | tRNA thio-modification |
| B | 0052837 | biological_process | thiazole biosynthetic process |
| B | 0140741 | molecular_function | tRNA-uracil-4 sulfurtransferase activity |
| B | 1990228 | cellular_component | sulfurtransferase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ATP A 401 |
| Chain | Residue |
| A | LEU180 |
| A | PHE206 |
| A | ARG264 |
| A | MET267 |
| A | THR285 |
| A | GLY286 |
| A | GLU287 |
| A | GLN291 |
| A | GLN295 |
| A | MG402 |
| A | LEU181 |
| A | SER182 |
| A | GLY184 |
| A | ILE185 |
| A | ASP186 |
| A | SER187 |
| A | VAL204 |
| A | THR205 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | ATP401 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ATP B 401 |
| Chain | Residue |
| B | LEU180 |
| B | LEU181 |
| B | SER182 |
| B | ASP186 |
| B | SER187 |
| B | VAL204 |
| B | PHE206 |
| B | ARG264 |
| B | MET267 |
| B | GLY286 |
| B | GLU287 |
| B | ASN288 |
| B | LYS320 |
| B | MG402 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG B 402 |
| Chain | Residue |
| B | ATP401 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 214 |
| Details | Domain: {"description":"THUMP","evidences":[{"source":"HAMAP-Rule","id":"MF_00021","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00021","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
