4KR7

Crystal structure of a 4-thiouridine synthetase - RNA complex with bound ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0002937	biological_process	tRNA 4-thiouridine biosynthesis
A	0003723	molecular_function	RNA binding
A	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0009228	biological_process	thiamine biosynthetic process
A	0009229	biological_process	thiamine diphosphate biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016783	molecular_function	sulfurtransferase activity
A	0034227	biological_process	tRNA thio-modification
A	0052837	biological_process	thiazole biosynthetic process
A	0140741	molecular_function	tRNA-uracil-4 sulfurtransferase activity
A	1990228	cellular_component	sulfurtransferase complex
B	0000049	molecular_function	tRNA binding
B	0000166	molecular_function	nucleotide binding
B	0002937	biological_process	tRNA 4-thiouridine biosynthesis
B	0003723	molecular_function	RNA binding
B	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0009228	biological_process	thiamine biosynthetic process
B	0009229	biological_process	thiamine diphosphate biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016783	molecular_function	sulfurtransferase activity
B	0034227	biological_process	tRNA thio-modification
B	0052837	biological_process	thiazole biosynthetic process
B	0140741	molecular_function	tRNA-uracil-4 sulfurtransferase activity
B	1990228	cellular_component	sulfurtransferase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ATP A 401

Chain	Residue
A	LEU180
A	PHE206
A	ARG264
A	MET267
A	THR285
A	GLY286
A	GLU287
A	GLN291
A	GLN295
A	MG402
A	LEU181
A	SER182
A	GLY184
A	ILE185
A	ASP186
A	SER187
A	VAL204
A	THR205

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 402

Chain	Residue
A	ATP401

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ATP B 401

Chain	Residue
B	LEU180
B	LEU181
B	SER182
B	ASP186
B	SER187
B	VAL204
B	PHE206
B	ARG264
B	MET267
B	GLY286
B	GLU287
B	ASN288
B	LYS320
B	MG402

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG B 402

Chain	Residue
B	ATP401

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	214
Details	Domain: {"description":"THUMP","evidences":[{"source":"HAMAP-Rule","id":"MF_00021","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00021","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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