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4KR6

Crystal structure of a 4-thiouridine synthetase - RNA complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000049molecular_functiontRNA binding
A0002937biological_processtRNA 4-thiouridine biosynthesis
A0003723molecular_functionRNA binding
A0004810molecular_functionCCA tRNA nucleotidyltransferase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0009228biological_processthiamine biosynthetic process
A0009229biological_processthiamine diphosphate biosynthetic process
A0016740molecular_functiontransferase activity
A0016783molecular_functionsulfurtransferase activity
A0034227biological_processtRNA thio-modification
A0052837biological_processthiazole biosynthetic process
A0140741molecular_functiontRNA-uracil-4 sulfurtransferase activity
B0000049molecular_functiontRNA binding
B0002937biological_processtRNA 4-thiouridine biosynthesis
B0003723molecular_functionRNA binding
B0004810molecular_functionCCA tRNA nucleotidyltransferase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0009228biological_processthiamine biosynthetic process
B0009229biological_processthiamine diphosphate biosynthetic process
B0016740molecular_functiontransferase activity
B0016783molecular_functionsulfurtransferase activity
B0034227biological_processtRNA thio-modification
B0052837biological_processthiazole biosynthetic process
B0140741molecular_functiontRNA-uracil-4 sulfurtransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE HG A 401
ChainResidue
ATYR166
AGLU329

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE HG A 403
ChainResidue
ACYS344
BILE89
BLYS92

site_idAC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE HG B 401
ChainResidue
BCYS344

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00021
ChainResidueDetails
ALEU180
BGLN295
ATHR205
AARG264
AGLY286
AGLN295
BLEU180
BTHR205
BARG264
BGLY286

223790

PDB entries from 2024-08-14

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