4KM9

Crystal structure of human Suppressor of Fused

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001843	biological_process	neural tube closure
A	0001947	biological_process	heart looping
A	0003281	biological_process	ventricular septum development
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005929	cellular_component	cilium
A	0006355	biological_process	regulation of DNA-templated transcription
A	0007165	biological_process	signal transduction
A	0007224	biological_process	smoothened signaling pathway
A	0007286	biological_process	spermatid development
A	0007368	biological_process	determination of left/right symmetry
A	0008013	molecular_function	beta-catenin binding
A	0008134	molecular_function	transcription factor binding
A	0019901	molecular_function	protein kinase binding
A	0021513	biological_process	spinal cord dorsal/ventral patterning
A	0021520	biological_process	spinal cord motor neuron cell fate specification
A	0021521	biological_process	ventral spinal cord interneuron specification
A	0021775	biological_process	smoothened signaling pathway involved in ventral spinal cord interneuron specification
A	0021776	biological_process	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
A	0021904	biological_process	dorsal/ventral neural tube patterning
A	0035904	biological_process	aorta development
A	0042308	biological_process	negative regulation of protein import into nucleus
A	0043588	biological_process	skin development
A	0045668	biological_process	negative regulation of osteoblast differentiation
A	0045879	biological_process	negative regulation of smoothened signaling pathway
A	0060976	biological_process	coronary vasculature development
A	0072595	biological_process	maintenance of protein localization in organelle
A	0097542	cellular_component	ciliary tip
A	0097546	cellular_component	ciliary base
A	0140311	molecular_function	protein sequestering activity
A	1990788	cellular_component	GLI-SUFU complex
A	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
A	2001040	biological_process	positive regulation of cellular response to drug

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27234298","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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