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4KJK

Room Temperature WT DHFR

Functional Information from GO Data
ChainGOidnamespacecontents
A0004146molecular_functiondihydrofolate reductase activity
A0005515molecular_functionprotein binding
A0005542molecular_functionfolic acid binding
A0005829cellular_componentcytosol
A0006545biological_processglycine biosynthetic process
A0006730biological_processone-carbon metabolic process
A0009410biological_processresponse to xenobiotic stimulus
A0016491molecular_functionoxidoreductase activity
A0031427biological_processresponse to methotrexate
A0046452biological_processdihydrofolate metabolic process
A0046654biological_processtetrahydrofolate biosynthetic process
A0046655biological_processfolic acid metabolic process
A0046677biological_processresponse to antibiotic
A0050661molecular_functionNADP binding
A0051870molecular_functionmethotrexate binding
A0051871molecular_functiondihydrofolic acid binding
A0070401molecular_functionNADP+ binding
A0070402molecular_functionNADPH binding
Functional Information from PDB Data
site_idAC1
Number of Residues21
DetailsBINDING SITE FOR RESIDUE FOL A 201
ChainResidue
AILE5
AILE50
AARG52
AARG57
AILE94
ATHR113
ANAP204
AHOH301
AHOH307
AHOH341
AHOH413
AALA6
AHOH442
AHOH454
AALA7
AMET20
AASP27
ALEU28
AALA29
APHE31
ALYS32

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE CA A 202
ChainResidue
AASP116
AHIS149
AARG159
AHOH302
AHOH310
AHOH311
AHOH314

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 203
ChainResidue
AVAL10
AVAL13
AVAL119
AHOH449

site_idAC4
Number of Residues38
DetailsBINDING SITE FOR RESIDUE NAP A 204
ChainResidue
AALA6
AALA7
AILE14
AGLY15
AASN18
AALA19
AMET20
ATRP22
AGLY43
AARG44
AHIS45
ATHR46
ASER49
ALEU62
ASER63
ASER64
AGLN65
ALYS76
AVAL78
AILE94
AGLY96
AGLY97
AARG98
AVAL99
ATYR100
AGLN102
ATHR123
AASP131
AFOL201
AHOH305
AHOH321
AHOH329
AHOH330
AHOH369
AHOH371
AHOH379
AHOH411
AHOH432

Functional Information from PROSITE/UniProt
site_idPS00075
Number of Residues23
DetailsDHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT
ChainResidueDetails
AVAL13-THR35

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsBINDING: BINDING => ECO:0000305|PubMed:9012674
ChainResidueDetails
AILE5
AASP27
AARG52
AARG57
ATHR113

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:19374017
ChainResidueDetails
AALA7
AVAL13
AHIS45
ASER63
ALYS76
AGLY95

217705

PDB entries from 2024-03-27

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