Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004713 | molecular_function | protein tyrosine kinase activity |
| C | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004713 | molecular_function | protein tyrosine kinase activity |
| D | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE G5K A 701 |
| Chain | Residue |
| A | ILE369 |
| A | ASP445 |
| A | LEU489 |
| A | HOH886 |
| A | HOH887 |
| A | HOH917 |
| C | ILE369 |
| C | G6K701 |
| A | ALA389 |
| A | PHE435 |
| A | GLU436 |
| A | PHE437 |
| A | MET438 |
| A | HIS440 |
| A | GLY441 |
| A | CYS442 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE G5K B 701 |
| Chain | Residue |
| B | ILE369 |
| B | ALA389 |
| B | PHE435 |
| B | GLU436 |
| B | PHE437 |
| B | MET438 |
| B | GLU439 |
| B | GLY441 |
| B | CYS442 |
| B | ASP445 |
| B | HOH801 |
| B | HOH901 |
| B | HOH924 |
| D | GLN367 |
| D | GLU368 |
| D | ILE369 |
| D | G6K701 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE G6K C 701 |
| Chain | Residue |
| C | ILE369 |
| C | ALA389 |
| C | PHE435 |
| C | GLU436 |
| C | PHE437 |
| C | MET438 |
| C | GLU439 |
| C | GLY441 |
| C | CYS442 |
| C | ASP445 |
| C | ARG486 |
| C | LEU489 |
| C | HOH810 |
| C | HOH811 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE G5K C 702 |
| Chain | Residue |
| A | GLN367 |
| C | ILE369 |
| C | ALA389 |
| C | PHE435 |
| C | GLU436 |
| C | PHE437 |
| C | MET438 |
| C | GLU439 |
| C | GLY441 |
| C | CYS442 |
| C | ASP445 |
| C | LEU489 |
| C | HOH810 |
| C | HOH811 |
| C | HOH812 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 C 703 |
| Chain | Residue |
| A | ARG451 |
| A | LYS556 |
| A | HOH949 |
| C | ARG448 |
| C | ARG451 |
| C | GLY555 |
| C | LYS556 |
| C | HOH802 |
| C | HOH900 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 704 |
| Chain | Residue |
| C | SER584 |
| C | THR585 |
| C | HOH817 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 705 |
| Chain | Residue |
| C | TRP549 |
| C | LEU577 |
| C | TYR578 |
| C | HOH945 |
| D | ARG562 |
| D | ASP570 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE G6K D 701 |
| Chain | Residue |
| B | GLN367 |
| B | ILE369 |
| B | G5K701 |
| B | HOH924 |
| D | ILE369 |
| D | ALA389 |
| D | PHE435 |
| D | GLU436 |
| D | PHE437 |
| D | MET438 |
| D | GLU439 |
| D | GLY441 |
| D | CYS442 |
| D | SER444 |
| D | ASP445 |
| D | LEU489 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 702 |
| Chain | Residue |
| D | HOH806 |
| D | HOH813 |
| D | HOH837 |
| D | LYS556 |
| D | TYR578 |
| D | ARG581 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 703 |
| Chain | Residue |
| C | GLN589 |
| D | LYS579 |
| D | THR585 |
| D | HOH832 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 23 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGQFGLVHlGywlnkdk...........VAIK |
| Chain | Residue | Details |
| A | ILE369-LYS391 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. VIHrDLAARNCLV |
| Chain | Residue | Details |
| A | VAL478-VAL490 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
