Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0047112 | molecular_function | pyruvate oxidase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0047112 | molecular_function | pyruvate oxidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE FAD A 701 |
| Chain | Residue |
| A | HIS101 |
| A | ARG264 |
| A | VAL265 |
| A | GLY284 |
| A | ASN285 |
| A | ASN286 |
| A | TYR287 |
| A | PRO288 |
| A | PHE289 |
| A | ASP306 |
| A | ILE307 |
| A | PHE121 |
| A | ASP308 |
| A | LYS311 |
| A | ASP325 |
| A | ALA326 |
| A | ASN398 |
| A | SER416 |
| A | ASN417 |
| A | HOH802 |
| A | HOH811 |
| A | HOH847 |
| A | GLY220 |
| A | HOH1078 |
| A | HOH1079 |
| A | HOH1184 |
| A | HOH1202 |
| A | HOH1342 |
| A | HOH1485 |
| A | ILE221 |
| A | GLY222 |
| A | THR244 |
| A | TYR245 |
| A | ALA262 |
| A | ASN263 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 702 |
| Chain | Residue |
| A | ASP447 |
| A | ASN474 |
| A | GLN476 |
| A | TPP704 |
| A | HOH803 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PO4 A 703 |
| Chain | Residue |
| A | GLY34 |
| A | GLY35 |
| A | SER36 |
| A | SER82 |
| A | PHE111 |
| A | GLN122 |
| A | ILE480 |
| A | TPP704 |
| A | HOH912 |
| A | HOH1019 |
| A | HOH1487 |
| A | HOH1598 |
| site_id | AC4 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE TPP A 704 |
| Chain | Residue |
| A | PRO33 |
| A | GLU59 |
| A | SER82 |
| A | PRO85 |
| A | HIS89 |
| A | GLN122 |
| A | VAL394 |
| A | ASP396 |
| A | ALA420 |
| A | MET422 |
| A | GLY446 |
| A | ASP447 |
| A | GLY448 |
| A | GLY449 |
| A | ASN474 |
| A | GLN476 |
| A | TYR477 |
| A | GLY478 |
| A | PHE479 |
| A | ILE480 |
| A | MG702 |
| A | PO4703 |
| A | HOH803 |
| A | HOH820 |
| A | HOH824 |
| A | HOH846 |
| A | HOH1487 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 705 |
| Chain | Residue |
| A | ALA23 |
| A | TRP24 |
| A | LYS75 |
| A | TYR158 |
| A | ALA186 |
| A | TYR189 |
| A | HOH1024 |
| A | HOH1421 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 706 |
| Chain | Residue |
| A | LYS433 |
| A | PRO437 |
| A | GLU438 |
| A | PRO466 |
| A | ALA533 |
| A | GLN534 |
| A | HOH1089 |
| A | HOH1121 |
| A | HOH1373 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 707 |
| Chain | Residue |
| A | HOH1291 |
| A | HOH1444 |
| A | TRP174 |
| A | THR487 |
| A | GLN489 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 708 |
| Chain | Residue |
| A | ARG264 |
| A | GLU483 |
| A | ASP486 |
| A | GLU553 |
| A | HOH1029 |
| A | HOH1222 |
| A | HOH1347 |
| A | HOH1483 |
| A | HOH1496 |
| A | HOH1629 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 709 |
| Chain | Residue |
| A | MET452 |
| A | MET452 |
| A | GLN455 |
| A | GLN455 |
| A | HOH825 |
| A | HOH825 |
| site_id | BC1 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD B 701 |
| Chain | Residue |
| B | HIS101 |
| B | PHE121 |
| B | GLY220 |
| B | ILE221 |
| B | GLY222 |
| B | THR244 |
| B | TYR245 |
| B | PRO246 |
| B | ALA262 |
| B | ASN263 |
| B | ARG264 |
| B | VAL265 |
| B | GLY284 |
| B | ASN285 |
| B | ASN286 |
| B | TYR287 |
| B | PRO288 |
| B | PHE289 |
| B | ASP306 |
| B | ILE307 |
| B | ASP308 |
| B | LYS311 |
| B | ASP325 |
| B | ALA326 |
| B | ASN398 |
| B | SER416 |
| B | ASN417 |
| B | HOH801 |
| B | HOH807 |
| B | HOH816 |
| B | HOH819 |
| B | HOH1132 |
| B | HOH1133 |
| B | HOH1336 |
| B | HOH1498 |
| B | HOH1553 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 702 |
| Chain | Residue |
| B | ASP447 |
| B | ASN474 |
| B | GLN476 |
| B | TPP703 |
| B | HOH802 |
| site_id | BC3 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE TPP B 703 |
| Chain | Residue |
| B | PRO33 |
| B | GLU59 |
| B | SER82 |
| B | PRO85 |
| B | HIS89 |
| B | GLN122 |
| B | VAL394 |
| B | ASP396 |
| B | ALA420 |
| B | MET422 |
| B | GLY446 |
| B | ASP447 |
| B | GLY448 |
| B | GLY449 |
| B | ASN474 |
| B | GLN476 |
| B | TYR477 |
| B | GLY478 |
| B | PHE479 |
| B | ILE480 |
| B | MG702 |
| B | PO4704 |
| B | HOH802 |
| B | HOH817 |
| B | HOH821 |
| B | HOH855 |
| B | HOH1496 |
| site_id | BC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PO4 B 704 |
| Chain | Residue |
| B | GLY34 |
| B | GLY35 |
| B | SER36 |
| B | SER82 |
| B | PHE111 |
| B | GLN122 |
| B | ILE480 |
| B | TPP703 |
| B | HOH873 |
| B | HOH1030 |
| B | HOH1356 |
| B | HOH1496 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 705 |
| Chain | Residue |
| B | LYS433 |
| B | PRO437 |
| B | GLU438 |
| B | PRO466 |
| B | ALA533 |
| B | GLN534 |
| B | HOH1176 |
| B | HOH1235 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 706 |
| Chain | Residue |
| B | THR487 |
| B | HOH1306 |
| B | HOH1712 |
| site_id | BC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 707 |
| Chain | Residue |
| A | HOH1083 |
| B | ALA569 |
| B | PHE570 |
| B | ARG573 |
| B | TYR574 |
| B | HOH961 |
| B | HOH980 |
| B | HOH1187 |
| B | HOH1379 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 708 |
| Chain | Residue |
| B | PRO409 |
| B | SER410 |
| B | ASN411 |
| B | ARG412 |
| B | TYR436 |
| B | ARG439 |
| B | GOL709 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 709 |
| Chain | Residue |
| B | PRO409 |
| B | ARG412 |
| B | GOL708 |
| B | HOH917 |
| B | HOH939 |
| B | HOH996 |
| B | HOH1558 |
Functional Information from PROSITE/UniProt
| site_id | PS00187 |
| Number of Residues | 20 |
| Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IAaklnyPerqvFnLaGDGG |
| Chain | Residue | Details |
| A | ILE430-GLY449 | |
