4KG3
Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain in complex with Mg (E153Q mutation)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| A | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| A | 0140933 | molecular_function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
| B | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| B | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| B | 0140933 | molecular_function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
| C | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| C | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| C | 0140933 | molecular_function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 301 |
| Chain | Residue |
| A | GLU149 |
| A | HOH401 |
| A | HOH406 |
| A | HOH408 |
| A | HOH412 |
| A | HOH513 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 301 |
| Chain | Residue |
| C | HOH402 |
| C | HOH404 |
| C | HOH532 |
| B | GLU149 |
| B | HOH403 |
| B | HOH406 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 301 |
| Chain | Residue |
| C | GLU149 |
| C | HOH416 |
| C | HOH419 |
| C | HOH434 |
| C | HOH486 |
| C | HOH533 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 63 |
| Details | Motif: {"description":"Nudix box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 127 |
| Details | Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
