Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4KET

Crystal structure of SsoPox W263I

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004063	molecular_function	aryldialkylphosphatase activity
A	0008270	molecular_function	zinc ion binding
A	0009056	biological_process	catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0046872	molecular_function	metal ion binding
B	0004063	molecular_function	aryldialkylphosphatase activity
B	0008270	molecular_function	zinc ion binding
B	0009056	biological_process	catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016788	molecular_function	hydrolase activity, acting on ester bonds
B	0046872	molecular_function	metal ion binding
C	0004063	molecular_function	aryldialkylphosphatase activity
C	0008270	molecular_function	zinc ion binding
C	0009056	biological_process	catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016788	molecular_function	hydrolase activity, acting on ester bonds
C	0046872	molecular_function	metal ion binding
D	0004063	molecular_function	aryldialkylphosphatase activity
D	0008270	molecular_function	zinc ion binding
D	0009056	biological_process	catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016788	molecular_function	hydrolase activity, acting on ester bonds
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE2 A 401

Chain	Residue
A	HIS22
A	HIS24
A	KCX137
A	ASP256
A	CO402
A	EDO403
A	HOH699

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO A 402

Chain	Residue
A	HIS199
A	ARG223
A	FE2401
A	EDO403
A	HOH699
A	KCX137
A	HIS170

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO A 403

Chain	Residue
A	HIS24
A	TYR97
A	KCX137
A	HIS170
A	ARG223
A	ASP256
A	FE2401
A	CO402
A	HOH699
A	HOH706

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 404

Chain	Residue
A	PRO4
A	LEU5
A	LYS8
A	ASP9
A	SER10
A	LEU130
A	ASN131
A	LYS132
A	HOH552
A	HOH681
A	HOH694

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 405

Chain	Residue
A	ASN160
A	LYS164
A	GLY189
A	VAL190
A	ASP191
A	HOH663
A	HOH676

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 406

Chain	Residue
A	HIS120
A	GLU124
A	GLY128
A	THR129
A	HOH557
A	HOH581
A	HOH700
A	HOH711

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 407

Chain	Residue
A	PHE104
C	TYR99
C	PG4404

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 401

Chain	Residue
A	GLU298
A	HOH609
A	HOH683
B	GLN58
B	HOH576

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE2 B 402

Chain	Residue
B	HIS22
B	HIS24
B	KCX137
B	ASP256
B	CO403
B	GOL404
B	HOH718

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO B 403

Chain	Residue
B	KCX137
B	HIS170
B	HIS199
B	ARG223
B	FE2402
B	GOL404
B	HOH718

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 404

Chain	Residue
B	HIS24
B	TYR97
B	KCX137
B	HIS170
B	ARG223
B	ASP256
B	FE2402
B	CO403
B	HOH718

site_id	BC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GOL B 405

Chain	Residue
B	PRO4
B	LEU5
B	LYS8
B	ASP9
B	SER10
B	LEU130
B	ASN131
B	LYS132
B	HOH542
B	HOH685
B	HOH686
B	HOH722
B	HOH729

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 406

Chain	Residue
B	LYS194
B	HOH636
B	ASN160
B	LYS164
B	GLY189
B	VAL190
B	ASP191

site_id	BC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PEG B 407

Chain	Residue
B	HIS120
B	GLU124
B	GLY125
B	ILE126
B	GLN127
B	GLY128
B	THR129
B	LEU130
B	HOH589
B	HOH656
D	LYS164
D	HOH507
D	HOH703

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 C 401

Chain	Residue
C	HIS22
C	HIS24
C	KCX137
C	ASP256
C	CO402
C	HOH688

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO C 402

Chain	Residue
C	KCX137
C	HIS170
C	HIS199
C	FE2401
C	PG4404
C	HOH688

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 403

Chain	Residue
C	ASP214
C	GLY246
C	TYR247
C	ASP249

site_id	BC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PG4 C 404

Chain	Residue
A	EDO407
C	TYR97
C	HIS170
C	ARG223
C	LEU226
C	ASP256
C	TRP278
C	CO402
C	HOH688
C	HOH707
C	HOH712

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 405

Chain	Residue
C	HIS120
C	GLU124
C	GLY128
C	THR129
C	HOH540
C	HOH550

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO C 406

Chain	Residue
C	LEU102
C	PRO103
C	PHE104
C	LEU107
C	ASP148
C	HOH704
C	HOH706

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 407

Chain	Residue
C	ASN160
C	LYS164
C	GLY189
C	ASP191
C	HOH599

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 D 401

Chain	Residue
D	HIS22
D	HIS24
D	KCX137
D	ASP256
D	CO402
D	HOH701

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CO D 402

Chain	Residue
D	KCX137
D	HIS170
D	HIS199
D	ARG223
D	FE2401
D	PG4404
D	HOH701

site_id	CC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO D 403

Chain	Residue
C	ILE243
C	GLY295
C	VAL296
C	ASN297
C	VAL300
D	GLU12
D	LYS14
D	ASP15
D	HOH696
D	HOH719

site_id	CC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PG4 D 404

Chain	Residue
D	TYR97
D	ARG223
D	ASP256
D	THR265
D	ALA266
D	ALA275
D	CO402
D	HOH701
D	HOH704

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 405

Chain	Residue
D	ASP112
D	ASP116
D	ILE119
D	HOH710
D	HOH722

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D 406

Chain	Residue
D	GLN58
D	PHE59
D	HOH718

site_id	DC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 407

Chain	Residue
D	ASN160
D	LYS164
D	GLY189
D	VAL190
D	ASP191
D	LYS194
D	HOH589
D	HOH706

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 408

Chain	Residue
D	ASP249
D	LYS250
D	LYS311
D	HOH678
D	HOH702

Functional Information from PROSITE/UniProt

site_id	PS01322
Number of Residues	9
Details	PHOSPHOTRIESTERASE_1 Phosphotriesterase family signature 1. GfTLiHEHL

Chain	Residue	Details
A	GLY17-LEU25

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18486146","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VC5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VC7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KER","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KF1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"description":"via carbamate group","evidences":[{"source":"PubMed","id":"18486146","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VC5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VC7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KER","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KF1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00679","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18486146","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VC5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VC7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KER","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KF1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)