Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4KES

Crystal structure of SsoPox W263T

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004063	molecular_function	aryldialkylphosphatase activity
A	0008270	molecular_function	zinc ion binding
A	0009056	biological_process	catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0046872	molecular_function	metal ion binding
B	0004063	molecular_function	aryldialkylphosphatase activity
B	0008270	molecular_function	zinc ion binding
B	0009056	biological_process	catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016788	molecular_function	hydrolase activity, acting on ester bonds
B	0046872	molecular_function	metal ion binding
C	0004063	molecular_function	aryldialkylphosphatase activity
C	0008270	molecular_function	zinc ion binding
C	0009056	biological_process	catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016788	molecular_function	hydrolase activity, acting on ester bonds
C	0046872	molecular_function	metal ion binding
D	0004063	molecular_function	aryldialkylphosphatase activity
D	0008270	molecular_function	zinc ion binding
D	0009056	biological_process	catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016788	molecular_function	hydrolase activity, acting on ester bonds
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE2 A 401

Chain	Residue
A	HIS22
A	HIS24
A	KCX137
A	ASP256
A	CO402
A	EDO407
A	HOH591

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO A 402

Chain	Residue
A	HIS199
A	FE2401
A	EDO407
A	HOH591
A	KCX137
A	HIS170

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG A 403

Chain	Residue
A	ASP256
A	EDO407

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 404

Chain	Residue
A	ASN160
A	LYS164
A	GLY189
A	ASP191
A	LYS194
A	HOH545

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 405

Chain	Residue
A	SER171
A	ASN172
A	ALA173
A	HIS174
A	ASP202
A	PHE229
A	HOH568
A	HOH590

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 406

Chain	Residue
A	ARG55
A	THR281
A	GLU285
A	HOH553
A	HOH631
B	PRO289
B	LYS292

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 407

Chain	Residue
A	TYR97
A	KCX137
A	FE2401
A	CO402
A	PEG403
A	HOH591

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 408

Chain	Residue
A	PRO289
A	ARG293
B	PRO276
B	ARG277
B	HOH529
B	HOH577
B	HOH586

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 409

Chain	Residue
A	LEU102
A	PRO103
A	PHE104
A	PHE106
A	LEU107
A	ASP148
A	LYS151

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 410

Chain	Residue
A	PRO4
A	LEU5
A	LYS8
A	ASP9
A	SER10
A	LEU130
A	ASN131
A	LYS132
A	HOH639

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 411

Chain	Residue
A	ILE98
A	TYR99
A	ILE100
A	ASP101
A	HOH511
A	HOH574
C	PHE104

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 401

Chain	Residue
A	PHE18
A	LYS292
A	GLU298
A	HOH599
B	GLN58
B	HOH659

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 B 402

Chain	Residue
B	HIS22
B	HIS24
B	KCX137
B	ASP256
B	CO403
B	HOH600

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO B 403

Chain	Residue
B	KCX137
B	HIS170
B	HIS199
B	FE2402
B	HOH600

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 404

Chain	Residue
B	ASN160
B	LYS164
B	GLY189
B	ASP191
B	HOH610
B	HOH663
C	MET1

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 405

Chain	Residue
B	ASP9
B	SER10
B	LEU130
B	ASN131
B	LYS132
B	PRO4
B	LEU5
B	LYS8

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 406

Chain	Residue
B	SER171
B	ASN172
B	ALA173
B	HIS174
B	ASP202
B	PHE229
B	HOH597
B	HOH644

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 407

Chain	Residue
B	ALA173
B	HIS174
B	ASN175
B	ASN176
B	ASN205
B	TYR208

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG B 408

Chain	Residue
B	ARG154
B	GLU188

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 409

Chain	Residue
B	HIS120
B	GLU124
B	GLY128
B	THR129
B	HOH518
B	HOH645

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 410

Chain	Residue
B	PHE18
B	LYS292
B	GLU298
B	HOH553
B	HOH640
B	HOH664

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 C 401

Chain	Residue
C	HIS22
C	HIS24
C	KCX137
C	ASP256
C	CO402
C	HOH572

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO C 402

Chain	Residue
C	KCX137
C	HIS170
C	HIS199
C	FE2401
C	HOH572

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 403

Chain	Residue
A	ARG77
C	ASN160
C	LYS164
C	GLY189
C	VAL190
C	ASP191
C	LYS194

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 404

Chain	Residue
C	ARG33
C	PRO37

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 405

Chain	Residue
C	ASN172
C	ALA173
C	HIS174
C	ASP202
C	PHE229
C	HOH589

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 D 401

Chain	Residue
D	HIS22
D	HIS24
D	KCX137
D	ASP256
D	CO402
D	HOH561

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO D 402

Chain	Residue
D	KCX137
D	HIS170
D	HIS199
D	FE2401
D	EDO403
D	HOH561

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 403

Chain	Residue
D	TYR97
D	KCX137
D	HIS170
D	ARG223
D	CO402
D	HOH561

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 404

Chain	Residue
D	ASN172
D	ALA173
D	HIS174
D	ASP202
D	PHE229
D	HOH522

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 405

Chain	Residue
D	ALA173
D	HIS174
D	ASN175
D	ASN176
D	ASN205

site_id	DC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 406

Chain	Residue
D	ASN160
D	LYS164
D	GLY189
D	VAL190
D	ASP191
D	LYS194

site_id	DC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO D 407

Chain	Residue
D	ARG26
D	PHE28
D	GLY73
D	ARG74
D	ASP75
D	MET79
D	HOH524

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 408

Chain	Residue
D	VAL6
D	GLY7
D	GLU80
D	LYS84
D	ASN131
D	HOH536

Functional Information from PROSITE/UniProt

site_id	PS01322
Number of Residues	9
Details	PHOSPHOTRIESTERASE_1 Phosphotriesterase family signature 1. GfTLiHEHL

Chain	Residue	Details
A	GLY17-LEU25

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18486146","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VC5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VC7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KER","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KF1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"description":"via carbamate group","evidences":[{"source":"PubMed","id":"18486146","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VC5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VC7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KER","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KF1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00679","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18486146","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VC5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VC7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KER","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KF1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)