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4KBS

Crystal structure of human ceramide-1-phosphate transfer protein (CPTP) in complex with 12:0 phosphatidic acid (12:0 PA)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005543molecular_functionphospholipid binding
A0005634cellular_componentnucleus
A0005640cellular_componentnuclear outer membrane
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0008289molecular_functionlipid binding
A0010008cellular_componentendosome membrane
A0010507biological_processnegative regulation of autophagy
A0032691biological_processnegative regulation of interleukin-1 beta production
A0035627biological_processceramide transport
A0046836biological_processglycolipid transport
A0120009biological_processintermembrane lipid transfer
A0120013molecular_functionlipid transfer activity
A1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
A1902387molecular_functionceramide 1-phosphate binding
A1902388molecular_functionceramide 1-phosphate transfer activity
A1902389biological_processceramide 1-phosphate transport
B0005543molecular_functionphospholipid binding
B0005634cellular_componentnucleus
B0005640cellular_componentnuclear outer membrane
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006869biological_processlipid transport
B0008289molecular_functionlipid binding
B0010008cellular_componentendosome membrane
B0010507biological_processnegative regulation of autophagy
B0032691biological_processnegative regulation of interleukin-1 beta production
B0035627biological_processceramide transport
B0046836biological_processglycolipid transport
B0120009biological_processintermembrane lipid transfer
B0120013molecular_functionlipid transfer activity
B1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
B1902387molecular_functionceramide 1-phosphate binding
B1902388molecular_functionceramide 1-phosphate transfer activity
B1902389biological_processceramide 1-phosphate transport
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PX2 A 301
ChainResidue
AILE53
AHOH471
AHOH488
BPHE52
BLYS55
BPX2301
AASP56
ALYS60
AARG106
AARG110
APHE121
AHIS150
AHOH422
AHOH442

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE PX2 B 301
ChainResidue
APHE52
ALYS55
APX2301
AHOH500
BILE53
BASP56
BLYS60
BARG106
BARG110
BPHE121
BHIS150
BEDO302
BHOH419
BHOH437
BHOH442

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 302
ChainResidue
BASP56
BVAL57
BARG110
BPX2301
BHOH437

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO B 303
ChainResidue
AASP140
AHOH479
BALA147
BALA148
BHIS150
BTRP152
BARG155
BHOH414

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:23863933
ChainResidueDetails
AASP56
BHIS150
ALYS60
AARG106
AARG110
AHIS150
BASP56
BLYS60
BARG106
BARG110

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PDB entries from 2024-07-17

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