Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4KB9

Crystal structure of wild-type HIV-1 protease with novel tricyclic P2-ligands GRL-0739A

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
A0042802molecular_functionidentical protein binding
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
B0042802molecular_functionidentical protein binding
Functional Information from PDB Data
site_idAC1
Number of Residues32
DetailsBINDING SITE FOR RESIDUE G79 A 201
ChainResidue
AARG8
APRO81
AVAL82
AILE84
AHOH1001
AHOH1002
AHOH1003
AHOH1008
AHOH1021
AHOH1099
AHOH1109
AASP25
BARG8
BASP25
BGLY27
BALA28
BASP29
BASP30
BGLY48
BGLY49
BILE50
BPRO81
AGLY27
BVAL82
BILE84
BHOH696
AALA28
AASP29
AASP30
AGLY48
AGLY49
AILE50

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 202
ChainResidue
ATRP6
AHOH1041

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ACT A 203
ChainResidue
ATHR4
ATRP6
APRO44
AHOH1041
AHOH1061
AHOH1085
AHOH1103

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ACT A 204
ChainResidue
ATRP6
APRO44
AHOH1102

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA B 501
ChainResidue
BASP60
BHOH601
BHOH602
BHOH603
BHOH606
BHOH607

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CL B 502
ChainResidue
AARG41
BTHR74
BASN88
BACT503
BHOH697
BHOH700

site_idAC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ACT B 503
ChainResidue
BASP30
BTHR74
BASN88
BCL502
BHOH610
BHOH658
BHOH697
BHOH699

site_idAC8
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 504
ChainResidue
ATHR12
AGLU65
AALA67
AGLY68
BGLN18
BMET36
BSER37
BHOH703

site_idAC9
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL B 505
ChainResidue
AGLN61
AHOH1007
AHOH1017
BLYS45
BMET46
BPHE53
BHOH620
BHOH696
BHOH704

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI
ChainResidueDetails
AALA22-ILE33

225946

PDB entries from 2024-10-09

PDB statisticsPDBj update infoContact PDBjnumon