Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4KAM

X-ray crystal structure of O-acetylhomoserine sulfhydrylase MetC from Mycobacterium marinum ATCC BAA-535 / M

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000096	biological_process	sulfur amino acid metabolic process
A	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
A	0004124	molecular_function	cysteine synthase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006535	biological_process	cysteine biosynthetic process from serine
A	0009086	biological_process	methionine biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0019346	biological_process	transsulfuration
A	0030170	molecular_function	pyridoxal phosphate binding
A	0071266	biological_process	'de novo' L-methionine biosynthetic process
A	0071269	biological_process	L-homocysteine biosynthetic process
A	1901605	biological_process	alpha-amino acid metabolic process
B	0000096	biological_process	sulfur amino acid metabolic process
B	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
B	0004124	molecular_function	cysteine synthase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006535	biological_process	cysteine biosynthetic process from serine
B	0009086	biological_process	methionine biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0019346	biological_process	transsulfuration
B	0030170	molecular_function	pyridoxal phosphate binding
B	0071266	biological_process	'de novo' L-methionine biosynthetic process
B	0071269	biological_process	L-homocysteine biosynthetic process
B	1901605	biological_process	alpha-amino acid metabolic process
C	0000096	biological_process	sulfur amino acid metabolic process
C	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
C	0004124	molecular_function	cysteine synthase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006535	biological_process	cysteine biosynthetic process from serine
C	0009086	biological_process	methionine biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0019346	biological_process	transsulfuration
C	0030170	molecular_function	pyridoxal phosphate binding
C	0071266	biological_process	'de novo' L-methionine biosynthetic process
C	0071269	biological_process	L-homocysteine biosynthetic process
C	1901605	biological_process	alpha-amino acid metabolic process
D	0000096	biological_process	sulfur amino acid metabolic process
D	0003961	molecular_function	O-acetylhomoserine aminocarboxypropyltransferase activity
D	0004124	molecular_function	cysteine synthase activity
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0006535	biological_process	cysteine biosynthetic process from serine
D	0009086	biological_process	methionine biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0019346	biological_process	transsulfuration
D	0030170	molecular_function	pyridoxal phosphate binding
D	0071266	biological_process	'de novo' L-methionine biosynthetic process
D	0071269	biological_process	L-homocysteine biosynthetic process
D	1901605	biological_process	alpha-amino acid metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	SER96
A	GLY97
A	GLN98
A	SER217
A	THR219
A	LYS220
A	HOH704
A	HOH705
A	HOH707

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 502

Chain	Residue
A	TYR122
A	GLY123
A	ARG414
A	HOH815

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 501

Chain	Residue
B	SER96
B	GLY97
B	GLN98
B	SER217
B	THR219
B	LYS220
B	ALA230
B	HOH658

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 502

Chain	Residue
B	TYR122
B	GLY123
B	ARG414
B	HOH663
B	HOH700

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C 501

Chain	Residue
C	SER96
C	GLY97
C	GLN98
C	SER217
C	THR219
C	LYS220
C	HOH696
C	HOH705
C	HOH824

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 502

Chain	Residue
C	TYR122
C	GLY123
C	ARG414
C	HOH789

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 501

Chain	Residue
D	SER96
D	GLY97
D	GLN98
D	SER217
D	THR219
D	HOH626

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 502

Chain	Residue
D	TYR122
D	GLY123
D	ARG414

Functional Information from PROSITE/UniProt

site_id	PS00868
Number of Residues	15
Details	CYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DIvvhSATKYLgGHG

Chain	Residue	Details
A	ASP212-GLY226

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)